Gene description for LEPR
Gene name leptin receptor
Gene symbol LEPR
Other names/aliases CD295
Species Homo sapiens
 Database cross references - LEPR
ExoCarta ExoCarta_3953
Entrez Gene 3953
HGNC 6554
MIM 601007
UniProt P48357  
 LEPR identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for LEPR
Molecular Function
    identical protein binding GO:0042802 IPI
    cytokine receptor activity GO:0004896 IEA
    transmembrane signaling receptor activity GO:0004888 TAS
    protein binding GO:0005515 IPI
Biological Process
    negative regulation of gluconeogenesis GO:0045721 IEA
    cholesterol metabolic process GO:0008203 IEA
    multicellular organismal development GO:0007275 TAS
    cell surface receptor signaling pathway GO:0007166 TAS
    cytokine-mediated signaling pathway GO:0019221 IEA
    negative regulation of hydrolase activity GO:0051346 IEA
    energy reserve metabolic process GO:0006112 TAS
Subcellular Localization
    extracellular region GO:0005576 IEA
    plasma membrane GO:0005886 TAS
    receptor complex GO:0043235 IDA
    integral component of membrane GO:0016021 IEA
 Experiment description of studies that identified LEPR in exosomes
Experiment ID 235
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for LEPR
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PIN1 5300
Two-hybrid Homo sapiens
2 SNX1 6642
Invivo Homo sapiens
3 LEP  
Invivo Homo sapiens
4 SNX2 6643
Invivo Homo sapiens
Invitro Homo sapiens
5 STAT3 6774
Invivo Homo sapiens
6 SOCS3 9021
Reconstituted Complex Homo sapiens
7 DGKZ  
Invivo Homo sapiens
Invitro Homo sapiens
Two-hybrid Homo sapiens
8 JAK3 3718
Affinity Capture-Western Homo sapiens
9 JAK2 3717
Invitro Homo sapiens
10 SNX4 8723
Invivo Homo sapiens
11 SNX6 58533
Invivo Homo sapiens
Invitro Homo sapiens
View the network image/svg+xml
 Pathways in which LEPR is involved
No pathways found

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