Gene description for LRCH3
Gene name leucine-rich repeats and calponin homology (CH) domain containing 3
Gene symbol LRCH3
Other names/aliases -
Species Homo sapiens
 Database cross references - LRCH3
ExoCarta ExoCarta_84859
Vesiclepedia VP_84859
Entrez Gene 84859
HGNC 28637
UniProt Q96II8  
 LRCH3 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells 36408942    
 Gene ontology annotations for LRCH3
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    septin cytoskeleton organization GO:0032185 IMP
Subcellular Localization
    cytoplasm GO:0005737 IC
    cytosol GO:0005829 IBA
    cytosol GO:0005829 IDA
 Experiment description of studies that identified LRCH3 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for LRCH3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 UTRN 7402
Proximity Label-MS Homo sapiens
2 DBN1 1627
Affinity Capture-MS Homo sapiens
3 KIF20A 10112
Affinity Capture-MS Homo sapiens
4 CALM1 801
Affinity Capture-MS Homo sapiens
5 Actb 11461
Affinity Capture-MS Mus musculus
6 ANKRD28 23243
Proximity Label-MS Homo sapiens
7 ANKRD50 57182
Affinity Capture-MS Homo sapiens
8 SEPT9 10801
Proximity Label-MS Homo sapiens
9 DYRK1A 1859
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 COPB2 9276
Affinity Capture-MS Homo sapiens
11 FBXW7  
Affinity Capture-MS Homo sapiens
12 CALD1 800
Affinity Capture-MS Homo sapiens
13 CALM3 808
Affinity Capture-MS Homo sapiens
14 FBXW8 26259
Affinity Capture-MS Homo sapiens
15 YWHAG 7532
Affinity Capture-MS Homo sapiens
16 SEPT8 23176
Proximity Label-MS Homo sapiens
17 TULP3 7289
Affinity Capture-MS Homo sapiens
18 ATG16L1 55054
Affinity Capture-MS Homo sapiens
19 CEP57  
Affinity Capture-MS Homo sapiens
20 MTMR10 54893
Affinity Capture-MS Homo sapiens
21 SH3BGRL 6451
Affinity Capture-MS Homo sapiens
22 OCLM  
Affinity Capture-MS Homo sapiens
23 KIF14 9928
Affinity Capture-MS Homo sapiens
24 ARHGEF11 9826
Affinity Capture-MS Homo sapiens
25 E2F4  
Affinity Capture-MS Homo sapiens
26 AURKA 6790
Affinity Capture-MS Homo sapiens
27 RBX1 9978
Affinity Capture-MS Homo sapiens
28 SMEK1 55671
Affinity Capture-MS Homo sapiens
29 PTP4A3  
Affinity Capture-MS Homo sapiens
30 LRCH1 23143
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
31 NTRK1 4914
Affinity Capture-MS Homo sapiens
32 DCAF7 10238
Affinity Capture-MS Homo sapiens
33 CBX5 23468
Affinity Capture-MS Homo sapiens
34 IFI16 3428
Affinity Capture-MS Homo sapiens
35 Cdca8  
Affinity Capture-MS Mus musculus
36 VCPIP1 80124
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
37 CRLF3 51379
Affinity Capture-MS Homo sapiens
38 SNTB1 6641
Proximity Label-MS Homo sapiens
39 TPX2  
Affinity Capture-MS Homo sapiens
40 LIMA1 51474
Affinity Capture-MS Homo sapiens
41 DGCR6L  
Two-hybrid Homo sapiens
42 S100P 6286
Affinity Capture-MS Homo sapiens
43 MOB1B 92597
Proximity Label-MS Homo sapiens
44 DOCK8 81704
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
45 DOCK7 85440
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
46 LRCH4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
47 RLIM 51132
Affinity Capture-MS Homo sapiens
48 RSU1 6251
Affinity Capture-MS Homo sapiens
49 ERLEC1 27248
Affinity Capture-MS Homo sapiens
50 SEPT11 55752
Proximity Label-MS Homo sapiens
51 CORO1C 23603
Affinity Capture-MS Homo sapiens
52 BASP1 10409
Affinity Capture-MS Homo sapiens
53 ANKRD52 283373
Proximity Label-MS Homo sapiens
54 MYO6 4646
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
55 MYC  
Affinity Capture-MS Homo sapiens
56 TMOD3 29766
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
57 DPM2 8818
Affinity Capture-MS Homo sapiens
58 SEPT7 989
Proximity Label-MS Homo sapiens
59 LRCH2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
60 RNF26  
Affinity Capture-MS Homo sapiens
61 TMSB4Y  
Affinity Capture-MS Homo sapiens
62 DOCK6 57572
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
63 MALL  
Affinity Capture-MS Homo sapiens
64 MLKL 197259
Affinity Capture-MS Homo sapiens
65 SUGT1 10910
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
66 SIRT6  
Affinity Capture-MS Homo sapiens
67 LRRC6  
Two-hybrid Homo sapiens
68 RPS21 6227
Cross-Linking-MS (XL-MS) Homo sapiens
69 CXCL6  
Affinity Capture-MS Homo sapiens
70 SAA1 6288
Affinity Capture-MS Homo sapiens
71 Myo1c 17913
Affinity Capture-MS Mus musculus
72 CAPZA2 830
Affinity Capture-MS Homo sapiens
73 SEPT10 151011
Proximity Label-MS Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
74 HDAC1 3065
Affinity Capture-MS Homo sapiens
75 Tuba3a 22144
Affinity Capture-MS Mus musculus
76 MIF 4282
Affinity Capture-MS Homo sapiens
77 TPM1 7168
Affinity Capture-MS Homo sapiens
78 ACTA1 58
Affinity Capture-MS Homo sapiens
79 CALM2 805
Affinity Capture-MS Homo sapiens
80 TMEM257  
Affinity Capture-MS Homo sapiens
81 PARD6B 84612
Affinity Capture-MS Homo sapiens
82 RAB7A 7879
Proximity Label-MS Homo sapiens
83 GAGE5  
Affinity Capture-MS Homo sapiens
84 EPHA2 1969
Proximity Label-MS Homo sapiens
85 PIH1D1  
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
86 ANK3  
Proximity Label-MS Homo sapiens
87 MOB1A 55233
Proximity Label-MS Homo sapiens
88 SNTB2 6645
Proximity Label-MS Homo sapiens
89 PARD6A  
Affinity Capture-MS Homo sapiens
90 UQCR11  
Affinity Capture-MS Homo sapiens
91 UBE2V2 7336
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which LRCH3 is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here