Gene description for MTMR10
Gene name myotubularin related protein 10
Gene symbol MTMR10
Other names/aliases -
Species Homo sapiens
 Database cross references - MTMR10
ExoCarta ExoCarta_54893
Vesiclepedia VP_54893
Entrez Gene 54893
HGNC 25999
UniProt Q9NXD2  
 MTMR10 identified in sEVs derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for MTMR10
Molecular Function
    phosphatidylinositol-3-phosphate phosphatase activity GO:0004438 IBA
Biological Process
    phosphatidylinositol dephosphorylation GO:0046856 IBA
Subcellular Localization
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 IDA
    cytosol GO:0005829 TAS
    membrane GO:0016020 IBA
 Experiment description of studies that identified MTMR10 in sEVs
1
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 211
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
cytochrome c|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 212
MISEV standards
✔
CEM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
Cytochrome C|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
4
Experiment ID 834
MISEV standards
✔
EM
Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
5
Experiment ID 835
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for MTMR10
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 YWHAH 7533
Affinity Capture-MS Homo sapiens
2 RBMXL1  
Affinity Capture-MS Homo sapiens
3 SMAD5 4090
Two-hybrid Homo sapiens
4 NEXN 91624
Affinity Capture-MS Homo sapiens
5 MTMR10 54893
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 AATK  
Two-hybrid Homo sapiens
7 Mtmr2  
Affinity Capture-MS Mus musculus
8 SVIL 6840
Affinity Capture-MS Homo sapiens
9 PLEKHG3 26030
Affinity Capture-MS Homo sapiens
10 NMNAT1  
Affinity Capture-MS Homo sapiens
11 YWHAZ 7534
Affinity Capture-MS Homo sapiens
12 PBRM1 55193
Affinity Capture-MS Homo sapiens
13 OSGEP 55644
Affinity Capture-MS Homo sapiens
14 GADD45GIP1  
Affinity Capture-MS Homo sapiens
15 ERBB3 2065
Two-hybrid Homo sapiens
16 RAI14 26064
Affinity Capture-MS Homo sapiens
17 MCAM 4162
Proximity Label-MS Homo sapiens
18 IDE 3416
Affinity Capture-MS Homo sapiens
19 PPP1R9A  
Affinity Capture-MS Homo sapiens
20 LONP2 83752
Affinity Capture-MS Homo sapiens
21 ARF6 382
Proximity Label-MS Homo sapiens
22 TP53RK 112858
Affinity Capture-MS Homo sapiens
23 LIMA1 51474
Affinity Capture-MS Homo sapiens
24 SMAD9  
Two-hybrid Homo sapiens
25 RBM14-RBM4 100526737
Affinity Capture-MS Homo sapiens
26 NUDT16 131870
Affinity Capture-MS Homo sapiens
27 MEOX2  
Two-hybrid Homo sapiens
28 CGN  
Affinity Capture-MS Homo sapiens
29 KRAS 3845
Proximity Label-MS Homo sapiens
30 MTMR2 8898
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
31 MPRIP 23164
Affinity Capture-MS Homo sapiens
32 MTM1 4534
Affinity Capture-MS Homo sapiens
33 KIF20B  
Affinity Capture-MS Homo sapiens
34 DDX55  
Affinity Capture-MS Homo sapiens
35 PTK7 5754
Two-hybrid Homo sapiens
36 LRCH3 84859
Affinity Capture-MS Homo sapiens
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