Gene description for ARHGEF11
Gene name Rho guanine nucleotide exchange factor (GEF) 11
Gene symbol ARHGEF11
Other names/aliases GTRAP48
Species Homo sapiens
 Database cross references - ARHGEF11
ExoCarta ExoCarta_9826
Entrez Gene 9826
HGNC 14580
MIM 605708
UniProt O15085  
 ARHGEF11 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for ARHGEF11
Molecular Function
    protein binding GO:0005515 IPI
    G-protein coupled receptor binding GO:0001664 IDA
    Rho guanyl-nucleotide exchange factor activity GO:0005089 TAS
    GTPase activator activity GO:0005096 IEA
Biological Process
    cytokinesis GO:0000910 NAS
    positive regulation of apoptotic process GO:0043065 TAS
    regulation of cell growth GO:0001558 NAS
    axon guidance GO:0007411 TAS
    regulation of small GTPase mediated signal transduction GO:0051056 TAS
    establishment of cell polarity GO:0030010 NAS
    movement of cell or subcellular component GO:0006928 NAS
    positive regulation of transcription, DNA-templated GO:0045893 IDA
    small GTPase mediated signal transduction GO:0007264 TAS
    termination of G-protein coupled receptor signaling pathway GO:0038032 IEA
    positive regulation of GTPase activity GO:0043547 TAS
    striated muscle contraction GO:0006941 NAS
    actin cytoskeleton organization GO:0030036 NAS
    G-protein coupled receptor signaling pathway GO:0007186 TAS
    neurotrophin TRK receptor signaling pathway GO:0048011 TAS
    Rho protein signal transduction GO:0007266 IDA
    apoptotic signaling pathway GO:0097190 TAS
Subcellular Localization
    cytosol GO:0005829 TAS
    intracellular GO:0005622 IC
    membrane GO:0016020 IEA
    cytoplasm GO:0005737 IDA
 Experiment description of studies that identified ARHGEF11 in exosomes
Experiment ID 237
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for ARHGEF11
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 GNA13 10672
Invivo Homo sapiens
2 PLXNB3 5365
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
3 PLXNB2 23654
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
4 GNA12 2768
Invivo Homo sapiens
5 RHOA 387
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
6 PLXNB1 5364
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
View the network image/svg+xml

Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here