Gene description for PLXNB1
Gene name plexin B1
Gene symbol PLXNB1
Other names/aliases PLEXIN-B1
PLXN5
SEP
Species Homo sapiens
 Database cross references - PLXNB1
ExoCarta ExoCarta_5364
Entrez Gene 5364
HGNC 9103
MIM 601053
UniProt O43157  
 PLXNB1 identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for PLXNB1
Molecular Function
    semaphorin receptor activity GO:0017154 TAS
    transmembrane signaling receptor activity GO:0004888 NAS
    GTPase activating protein binding GO:0032794 ISS
    protein binding GO:0005515 IPI
    semaphorin receptor binding GO:0030215 TAS
    receptor activity GO:0004872 TAS
Biological Process
    ossification involved in bone maturation GO:0043931 ISS
    regulation of cytoskeleton organization GO:0051493 IDA
    signal transduction GO:0007165 TAS
    negative regulation of osteoblast proliferation GO:0033689 ISS
    positive regulation of GTPase activity GO:0043547 ISS
    positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 ISS
    axon guidance GO:0007411 TAS
    semaphorin-plexin signaling pathway GO:0071526 IDA
    regulation of cell shape GO:0008360 IDA
    semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis GO:1900220 ISS
    neuron projection morphogenesis GO:0048812 ISS
    intracellular signal transduction GO:0035556 NAS
    cell migration GO:0016477 NAS
    positive regulation of axonogenesis GO:0050772 IEA
    negative regulation of cell adhesion GO:0007162 IDA
Subcellular Localization
    integral component of plasma membrane GO:0005887 NAS
    plasma membrane GO:0005886 TAS
    semaphorin receptor complex GO:0002116 TAS
    extracellular region GO:0005576 IEA
    intracellular GO:0005622 NAS
 Experiment description of studies that identified PLXNB1 in exosomes
1
Experiment ID 211
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
EpCAM|TFRC
EV Membrane markers
cytochrome c|GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
ISEV standards
CEM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
EpCAM|TFRC
EV Membrane markers
Cytochrome C|GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for PLXNB1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 RND3 390
Reconstituted Complex Homo sapiens
2 PLXNA1 5361
Invivo Homo sapiens
Two-hybrid Homo sapiens
3 SEMA4D  
Invivo Homo sapiens
Invitro Homo sapiens
4 ARHGEF12 23365
Invivo Homo sapiens
Invitro Homo sapiens
Two-hybrid Homo sapiens
5 RND2  
Reconstituted Complex Homo sapiens
6 RND1  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
7 ARHGEF11 9826
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
View the network image/svg+xml



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here