Gene description for Tgfbr1
Gene name	transforming growth factor, beta receptor I
Gene symbol	Tgfbr1
Other names/aliases	ALK5 AU017191 Alk-5 TbetaR-I TbetaRI
Species	Mus musculus
Database cross references - Tgfbr1
ExoCarta	ExoCarta_21812
Vesiclepedia	VP_21812
Entrez Gene	21812
UniProt	Q64729
Tgfbr1 identified in exosomes derived from the following tissue/cell type
Breast cancer cells	34112803
Breast cancer cells	34112803

Gene ontology annotations for Tgfbr1

Molecular Function     transferase activity GO:0016740 IEA     protein kinase activity GO:0004672 ISO     transforming growth factor beta binding GO:0050431 ISO     ATP binding GO:0005524 ISO     protein heterodimerization activity GO:0046982 ISO     metal ion binding GO:0046872 IEA     receptor signaling protein serine/threonine kinase activity GO:0004702 IEA     transmembrane receptor protein serine/threonine kinase activity GO:0004675 IEA     protein complex binding GO:0032403 ISO     transforming growth factor beta-activated receptor activity GO:0005024 ISO     ubiquitin protein ligase binding GO:0031625 ISO     transferase activity, transferring phosphorus-containing groups GO:0016772 IEA     kinase activity GO:0016301 IEA     I-SMAD binding GO:0070411 ISO     transforming growth factor beta receptor activity, type I GO:0005025 ISO     type II transforming growth factor beta receptor binding GO:0005114 ISO     SMAD binding GO:0046332 ISO     protein serine/threonine kinase activity GO:0004674 ISO     growth factor binding GO:0019838 ISO     nucleotide binding GO:0000166 IEA     protein binding GO:0005515 IPI Biological Process     pathway-restricted SMAD protein phosphorylation GO:0060389 ISO     thymus development GO:0048538 IMP     positive regulation of cellular component movement GO:0051272 ISO     embryo development GO:0009790 IMP     positive regulation of transcription, DNA-templated GO:0045893 ISO     negative regulation of endothelial cell differentiation GO:0045602 ISO     blastocyst development GO:0001824 IDA     kidney development GO:0001822 IGI     anterior/posterior pattern specification GO:0009952 IGI     regulation of protein binding GO:0043393 IMP     skeletal system morphogenesis GO:0048705 IGI     palate development GO:0060021 IMP     epithelial to mesenchymal transition GO:0001837 ISO     pharyngeal system development GO:0060037 IMP     negative regulation of chondrocyte differentiation GO:0032331 IMP     collagen fibril organization GO:0030199 IMP     apoptotic process GO:0006915 IEA     negative regulation of endothelial cell proliferation GO:0001937 IGI     germ cell migration GO:0008354 IMP     transforming growth factor beta receptor signaling pathway GO:0007179 ISO     regulation of gene expression GO:0010468 IMP     positive regulation of SMAD protein import into nucleus GO:0060391 ISO     cellular response to transforming growth factor beta stimulus GO:0071560 ISO     cell motility GO:0048870 ISO     negative regulation of apoptotic process GO:0043066 IMP     phosphorylation GO:0016310 IEA     positive regulation of protein kinase B signaling GO:0051897 ISO     regulation of transcription, DNA-templated GO:0006355 ISO     positive regulation of filopodium assembly GO:0051491 IMP     negative regulation of extrinsic apoptotic signaling pathway GO:2001237 ISO     skeletal system development GO:0001501 IGI     transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 IGI     neuron fate commitment GO:0048663 IMP     artery morphogenesis GO:0048844 IMP     response to estrogen GO:0043627 ISO     regulation of protein ubiquitination GO:0031396 ISO     signal transduction GO:0007165 ISO     angiogenesis GO:0001525 IMP     positive regulation of apoptotic signaling pathway GO:2001235 ISO     embryonic cranial skeleton morphogenesis GO:0048701 IMP     lens development in camera-type eye GO:0002088 IMP     positive regulation of cell growth GO:0030307 ISO     heart development GO:0007507 IMP     cell differentiation GO:0030154 IEA     protein phosphorylation GO:0006468 ISO     post-embryonic development GO:0009791 IMP     male gonad development GO:0008584 IMP     positive regulation of cell proliferation GO:0008284 ISO     endothelial cell migration GO:0043542 IMP     response to cholesterol GO:0070723 ISO     regulation of growth GO:0040008 IEA     peptidyl-threonine phosphorylation GO:0018107 ISO     positive regulation of pathway-restricted SMAD protein phosphorylation GO:0010862 ISO     protein autophosphorylation GO:0046777 ISO     peptidyl-serine phosphorylation GO:0018105 ISO     activation of MAPKK activity GO:0000186 ISO     parathyroid gland development GO:0060017 IMP     in utero embryonic development GO:0001701 IMP Subcellular Localization     endosome GO:0005768 IDA     membrane raft GO:0045121 ISO     membrane GO:0016020 IEA     caveola GO:0005901 ISO     plasma membrane GO:0005886 ISO     bicellular tight junction GO:0005923 ISO     cell junction GO:0030054 IEA     integral component of membrane GO:0016021 IEA     basolateral plasma membrane GO:0016323 ISO     apical plasma membrane GO:0016324 ISO     protein complex GO:0043234 ISO     receptor complex GO:0043235 ISO