Gene description for Lrp1
Gene name low density lipoprotein receptor-related protein 1
Gene symbol Lrp1
Other names/aliases A2mr
Species Mus musculus
 Database cross references - Lrp1
ExoCarta ExoCarta_16971
Entrez Gene 16971
UniProt Q91ZX7  
 Lrp1 identified in exosomes derived from the following tissue/cell type
Fibroblasts 23260141    
 Gene ontology annotations for Lrp1
Molecular Function
    poly(A) RNA binding GO:0044822 ISO
    protein complex binding GO:0032403 ISO
    protein binding GO:0005515 IPI
    apolipoprotein binding GO:0034185 ISO
    protease binding GO:0002020 ISO
    calcium ion binding GO:0005509 IDA
    metal ion binding GO:0046872 IEA
Biological Process
    cholesterol metabolic process GO:0008203 IMP
    cell proliferation GO:0008283 ISO
    receptor-mediated endocytosis GO:0006898 ISO
    negative regulation of smooth muscle cell migration GO:0014912 IMP
    negative regulation of neuron apoptotic process GO:0043524 ISO
    endocytosis GO:0006897 IEA
    regulation of phospholipase A2 activity GO:0032429 IMP
    apoptotic cell clearance GO:0043277 IMP
    multicellular organismal development GO:0007275 IEA
    regulation of actin cytoskeleton organization GO:0032956 IMP
    regulation of cholesterol transport GO:0032374 IMP
    negative regulation of platelet-derived growth factor receptor-beta signaling pathway GO:2000587 IMP
    positive regulation of cholesterol efflux GO:0010875 IMP
    negative regulation of neuron projection development GO:0010977 ISO
    positive regulation of protein transport GO:0051222 ISO
    aorta morphogenesis GO:0035909 IMP
    positive regulation of lipid transport GO:0032370 IMP
    negative regulation of Wnt signaling pathway GO:0030178 IDA
    protein kinase C-activating G-protein coupled receptor signaling pathway GO:0007205 ISO
    beta-amyloid clearance GO:0097242 IMP
Subcellular Localization
    perinuclear region of cytoplasm GO:0048471 ISO
    dendrite GO:0030425 ISO
    neuronal cell body GO:0043025 ISO
    focal adhesion GO:0005925 ISO
    membrane GO:0016020 IDA
    receptor complex GO:0043235 ISO
    integral component of membrane GO:0016021 IEA
    endosome GO:0005768 ISO
    plasma membrane GO:0005886 IEA
    coated pit GO:0005905 IEA
    integral component of plasma membrane GO:0005887 IDA
    clathrin-coated vesicle GO:0030136 ISO
    nucleus GO:0005634 IEA
    lysosomal membrane GO:0005765 ISO
    cytoplasm GO:0005737 ISO
    nucleolus GO:0005730 ISO
 Experiment description of studies that identified Lrp1 in exosomes
Experiment ID 210
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23260141    
Organism Mus musculus
Experiment description Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration.
Authors Luga V, Zhang L, Viloria-Petit AM, Ogunjimi AA, Inanlou MR, Chiu E, Buchanan M, Hosein AN, Basik M, Wrana JL.
Journal name Cell
Publication year 2012
Sample Fibroblasts
Sample name Normal-Fibroblasts (L cells)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Lrp1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Lrp1 is involved
Retinoid metabolism and transport IEA Reactome
Scavenging of heme from plasma IEA Reactome

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