Gene description for ARHGEF40
Gene name Rho guanine nucleotide exchange factor (GEF) 40
Gene symbol ARHGEF40
Other names/aliases SOLO
Species Homo sapiens
 Database cross references - ARHGEF40
ExoCarta ExoCarta_55701
Vesiclepedia VP_55701
Entrez Gene 55701
HGNC 25516
MIM 610018
UniProt Q8TER5  
 ARHGEF40 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells 36408942    
 Gene ontology annotations for ARHGEF40
Molecular Function
    guanyl-nucleotide exchange factor activity GO:0005085 IBA
    guanyl-nucleotide exchange factor activity GO:0005085 TAS
    protein binding GO:0005515 IPI
Biological Process
    axon guidance GO:0007411 IBA
    regulation of small GTPase mediated signal transduction GO:0051056 TAS
Subcellular Localization
    cytoplasm GO:0005737 IBA
    cytosol GO:0005829 IDA
    cytosol GO:0005829 TAS
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IDA
    extrinsic component of membrane GO:0019898 IBA
 Experiment description of studies that identified ARHGEF40 in exosomes
1
Experiment ID 489
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 488
MISEV standards
EM
Biophysical techniques
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for ARHGEF40
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 GPSM2  
Two-hybrid Homo sapiens
2 MAGEA8  
Affinity Capture-MS Homo sapiens
3 FTL 2512
Affinity Capture-MS Homo sapiens
4 MYCBP 26292
Two-hybrid Homo sapiens
5 CASP14 23581
Affinity Capture-MS Homo sapiens
6 SPIN3  
Affinity Capture-MS Homo sapiens
7 FAM175B 23172
Affinity Capture-MS Homo sapiens
8 SERPINB3 6317
Affinity Capture-MS Homo sapiens
9 H2BFWT  
Affinity Capture-MS Homo sapiens
10 LGR4 55366
Affinity Capture-MS Homo sapiens
11 CXCR4 7852
Affinity Capture-MS Homo sapiens
12 ARHGEF11 9826
Affinity Capture-MS Homo sapiens
13 DYRK1B  
Affinity Capture-MS Homo sapiens
14 PIP 5304
Affinity Capture-MS Homo sapiens
15 TNKS 8658
Affinity Capture-MS Homo sapiens
16 PPIL4  
Affinity Capture-MS Homo sapiens
17 CD2BP2 10421
Affinity Capture-MS Homo sapiens
18 SPERT  
Two-hybrid Homo sapiens
19 CD6 923
Affinity Capture-MS Homo sapiens
20 P4HA1 5033
Affinity Capture-MS Homo sapiens
21 DSG1 1828
Affinity Capture-MS Homo sapiens
22 GCGR  
Affinity Capture-MS Homo sapiens
23 SLIRP 81892
Affinity Capture-MS Homo sapiens
24 TNKS2 80351
Affinity Capture-MS Homo sapiens
25 PLEKHG4B 153478
Affinity Capture-MS Homo sapiens
26 AZGP1 563
Affinity Capture-MS Homo sapiens
27 SOX2  
Affinity Capture-MS Homo sapiens
28 APP 351
Reconstituted Complex Homo sapiens
29 HNRNPCL2 440563
Affinity Capture-MS Homo sapiens
30 DUS3L 56931
Affinity Capture-MS Homo sapiens
31 STC2 8614
Two-hybrid Homo sapiens
32 ALDH18A1 5832
Affinity Capture-MS Homo sapiens
33 TGM3 7053
Affinity Capture-MS Homo sapiens
34 INSRR 3645
Affinity Capture-MS Homo sapiens
35 NTRK1 4914
Affinity Capture-MS Homo sapiens
36 CHCHD2  
Affinity Capture-MS Homo sapiens
37 BRD1 23774
Affinity Capture-MS Homo sapiens
38 LPAR4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
39 P2RY10  
Affinity Capture-MS Homo sapiens
40 FBL 2091
Affinity Capture-MS Homo sapiens
41 ARHGEF12 23365
Proximity Label-MS Homo sapiens
42 SPANXN2  
Affinity Capture-MS Homo sapiens
43 KPRP 448834
Affinity Capture-MS Homo sapiens
44 SRRT 51593
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here