Gene description for STC2
Gene name stanniocalcin 2
Gene symbol STC2
Other names/aliases STC-2
STCRP
Species Homo sapiens
 Database cross references - STC2
ExoCarta ExoCarta_8614
Vesiclepedia VP_8614
Entrez Gene 8614
HGNC 11374
MIM 603665
UniProt O76061  
 STC2 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells Unpublished / Not applicable
 Gene ontology annotations for STC2
Molecular Function
    heme binding GO:0020037 IDA
    hormone activity GO:0005179 IEA
    enzyme binding GO:0019899 IDA
    protein homodimerization activity GO:0042803 IDA
Biological Process
    endoplasmic reticulum unfolded protein response GO:0030968 IEA
    cellular response to hypoxia GO:0071456 IEA
    embryo implantation GO:0007566 IEA
    cellular calcium ion homeostasis GO:0006874 IEA
    response to peptide hormone GO:0043434 IEA
    decidualization GO:0046697 IEA
    regulation of hormone biosynthetic process GO:0046885 IDA
    regulation of store-operated calcium entry GO:2001256 IEA
    negative regulation of multicellular organism growth GO:0040015 IEA
    negative regulation of gene expression GO:0010629 IDA
    response to oxidative stress GO:0006979 IEA
    response to vitamin D GO:0033280 IEA
Subcellular Localization
    extracellular space GO:0005615 IDA
    Golgi apparatus GO:0005794 IEA
    perinuclear region of cytoplasm GO:0048471 IDA
    endoplasmic reticulum GO:0005783 IDA
 Experiment description of studies that identified STC2 in exosomes
1
Experiment ID 126
MISEV standards
✘ EV Biophysical techniques
✔
GAPDH
EV Enriched markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [LTQ-FT Ultra]
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
 Protein-protein interactions for STC2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 POLR2C 5432
Two-hybrid Homo sapiens
2 ADAM11 4185
Two-hybrid Homo sapiens
3 PTN  
Two-hybrid Homo sapiens
4 POLR3F  
Two-hybrid Homo sapiens
5 CARHSP1 23589
Two-hybrid Homo sapiens
6 ARRB2 409
Two-hybrid Homo sapiens
7 AIFM1 9131
Two-hybrid Homo sapiens
8 ARHGEF40 55701
Two-hybrid Homo sapiens
9 PEBP1 5037
Two-hybrid Homo sapiens
10 EIF2B3 8891
Two-hybrid Homo sapiens
11 PPP1R8 5511
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which STC2 is involved
No pathways found





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