Gene description for ADAM11
Gene name ADAM metallopeptidase domain 11
Gene symbol ADAM11
Other names/aliases MDC
Species Homo sapiens
 Database cross references - ADAM11
ExoCarta ExoCarta_4185
Vesiclepedia VP_4185
Entrez Gene 4185
HGNC 189
MIM 155120
UniProt O75078  
 ADAM11 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for ADAM11
Molecular Function
    metalloendopeptidase activity GO:0004222 IBA
    integrin binding GO:0005178 TAS
    metallopeptidase activity GO:0008237 TAS
Biological Process
    proteolysis GO:0006508 IBA
    integrin-mediated signaling pathway GO:0007229 TAS
    multicellular organismal response to stress GO:0033555 ISS
    establishment of protein localization GO:0045184 ISS
    behavioral response to acetic acid induced pain GO:0061367 ISS
    behavioral response to formalin induced pain GO:0061368 ISS
Subcellular Localization
    plasma membrane GO:0005886 TAS
    axon GO:0030424 IEA
    presynaptic membrane GO:0042734 IEA
    perikaryon GO:0043204 IEA
    collagen-containing extracellular matrix GO:0062023 ISS
 Experiment description of studies that identified ADAM11 in exosomes
1
Experiment ID 237
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for ADAM11
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ADAM23 8745
Affinity Capture-MS Homo sapiens
2 INTS4  
Affinity Capture-MS Homo sapiens
3 GPIHBP1  
Affinity Capture-MS Homo sapiens
4 RHOBTB3 22836
Affinity Capture-MS Homo sapiens
5 DEFB109P1B  
Affinity Capture-MS Homo sapiens
6 TAZ  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 EPHA4 2043
Affinity Capture-MS Homo sapiens
8 DEFB110  
Affinity Capture-MS Homo sapiens
9 ARF5 381
Affinity Capture-MS Homo sapiens
10 MTG2  
Affinity Capture-MS Homo sapiens
11 CBLN4  
Affinity Capture-MS Homo sapiens
12 RAB32 10981
Affinity Capture-MS Homo sapiens
13 PRKDC 5591
Affinity Capture-MS Homo sapiens
14 NLRX1 79671
Affinity Capture-MS Homo sapiens
15 APEX1 328
Affinity Capture-RNA Homo sapiens
16 HPCAL1 3241
Affinity Capture-MS Homo sapiens
17 CLEC12B  
Affinity Capture-MS Homo sapiens
18 MSMB  
Affinity Capture-MS Homo sapiens
19 DEFB107A  
Affinity Capture-MS Homo sapiens
20 JAK1 3716
Affinity Capture-MS Homo sapiens
21 RDH13  
Affinity Capture-MS Homo sapiens
22 RAB3B 5865
Affinity Capture-MS Homo sapiens
23 STC2 8614
Two-hybrid Homo sapiens
24 KLRC1  
Affinity Capture-MS Homo sapiens
25 NCAPH2  
Affinity Capture-MS Homo sapiens
26 IGFL3  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which ADAM11 is involved
PathwayEvidenceSource
Developmental Biology TAS Reactome
LGI-ADAM interactions TAS Reactome





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