Gene description for Tmod3
Gene name tropomodulin 3
Gene symbol Tmod3
Other names/aliases U-Tmod
UTMOD
Species Mus musculus
 Database cross references - Tmod3
ExoCarta ExoCarta_50875
Vesiclepedia VP_50875
Entrez Gene 50875
UniProt Q9JHJ0  
 Tmod3 identified in exosomes derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Tmod3
Molecular Function
    actin binding GO:0003779 IEA
    microtubule minus-end binding GO:0051011 ISO
    tropomyosin binding GO:0005523 IDA
Biological Process
    negative regulation of cellular component movement GO:0051271 ISO
    actin filament organization GO:0007015 IBA
    erythrocyte development GO:0048821 IMP
    positive regulation of mitotic cell cycle phase transition GO:1901992 IMP
    myofibril assembly GO:0030239 IBA
    pointed-end actin filament capping GO:0051694 ISO
    actin cytoskeleton organization GO:0030036 IMP
    muscle contraction GO:0006936 IBA
Subcellular Localization
    filamentous actin GO:0031941 ISO
    striated muscle thin filament GO:0005865 IDA
    myofibril GO:0030016 IBA
    cytoskeleton GO:0005856 IBA
    lamellipodium GO:0030027 ISO
    ruffle GO:0001726 ISO
    cytoplasm GO:0005737 IEA
 Experiment description of studies that identified Tmod3 in exosomes
1
Experiment ID 907
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Tmod3
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Tmod3 is involved
No pathways found





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