Gene description for PALM
Gene name paralemmin
Gene symbol PALM
Other names/aliases -
Species Homo sapiens
 Database cross references - PALM
ExoCarta ExoCarta_5064
Entrez Gene 5064
HGNC 8594
MIM 608134
UniProt O75781  
 PALM identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for PALM
Molecular Function
    D3 dopamine receptor binding GO:0031750 IEA
    protein binding GO:0005515 IPI
Biological Process
    cytoskeleton organization GO:0007010 IEA
    negative regulation of dopamine receptor signaling pathway GO:0060160 IDA
    synapse maturation GO:0060074 IEA
    positive regulation of dendritic spine development GO:0060999 IEA
    regulation of cell shape GO:0008360 IEA
    cellular response to electrical stimulus GO:0071257 IEA
    protein targeting to plasma membrane GO:0072661 IEA
    negative regulation of adenylate cyclase activity GO:0007194 IDA
    positive regulation of filopodium assembly GO:0051491 IDA
    movement of cell or subcellular component GO:0006928 TAS
Subcellular Localization
    filopodium membrane GO:0031527 IDA
    nucleoplasm GO:0005654 IDA
    basolateral plasma membrane GO:0016323 IEA
    dendrite membrane GO:0032590 IEA
    nucleus GO:0005634 IDA
    intracellular membrane-bounded organelle GO:0043231 IDA
    axon GO:0030424 IEA
    integral component of plasma membrane GO:0005887 TAS
    cytoplasmic membrane-bounded vesicle GO:0016023 TAS
    plasma membrane GO:0005886 IDA
    dendritic spine membrane GO:0032591 IEA
    apicolateral plasma membrane GO:0016327 IEA
 Experiment description of studies that identified PALM in exosomes
1
Experiment ID 211
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
EpCAM|TFRC
EV Membrane markers
✔
cytochrome c|GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
ISEV standards
✔
CEM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
EpCAM|TFRC
EV Membrane markers
✔
Cytochrome C|GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for PALM
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which PALM is involved
No pathways found





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