Gene description for HS2ST1
Gene name heparan sulfate 2-O-sulfotransferase 1
Gene symbol HS2ST1
Other names/aliases dJ604K5.2
Species Homo sapiens
 Database cross references - HS2ST1
ExoCarta ExoCarta_9653
Entrez Gene 9653
HGNC 5193
MIM 604844
UniProt Q7LGA3  
 HS2ST1 identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for HS2ST1
Molecular Function
    sulfotransferase activity GO:0008146 IEA
Biological Process
    glycosaminoglycan metabolic process GO:0030203 TAS
    glycosaminoglycan biosynthetic process GO:0006024 TAS
    carbohydrate metabolic process GO:0005975 TAS
    small molecule metabolic process GO:0044281 TAS
Subcellular Localization
    membrane GO:0016020 IDA
    Golgi membrane GO:0000139 TAS
    integral component of membrane GO:0016021 IEA
 Experiment description of studies that identified HS2ST1 in exosomes
1
Experiment ID 211
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
EpCAM|TFRC
EV Membrane markers
✔
cytochrome c|GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
ISEV standards
✔
CEM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
EpCAM|TFRC
EV Membrane markers
✔
Cytochrome C|GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for HS2ST1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which HS2ST1 is involved
PathwayEvidenceSource
HS-GAG biosynthesis TAS Reactome





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