Gene description for NMNAT3
Gene name nicotinamide nucleotide adenylyltransferase 3
Gene symbol NMNAT3
Other names/aliases FKSG76
PNAT-3
PNAT3
Species Homo sapiens
 Database cross references - NMNAT3
ExoCarta ExoCarta_349565
Entrez Gene 349565
HGNC 20989
MIM 608702
UniProt Q96T66  
 NMNAT3 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for NMNAT3
Molecular Function
    ATP binding GO:0005524 IEA
    nicotinamide-nucleotide adenylyltransferase activity GO:0000309 TAS
    nicotinate-nucleotide adenylyltransferase activity GO:0004515 IDA
Biological Process
    vitamin metabolic process GO:0006766 TAS
    NAD biosynthetic process GO:0009435 IEA
    small molecule metabolic process GO:0044281 TAS
    response to wounding GO:0009611 IEA
    NAD metabolic process GO:0019674 TAS
    water-soluble vitamin metabolic process GO:0006767 TAS
Subcellular Localization
    mitochondrion GO:0005739 IDA
    cytosol GO:0005829 TAS
 Experiment description of studies that identified NMNAT3 in exosomes
1
Experiment ID 237
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
✘ EV Membrane markers
✔
HSP90B1
EV Negative markers
✔
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for NMNAT3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 NMNAT3 349565
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which NMNAT3 is involved
PathwayEvidenceSource
Nicotinate metabolism TAS Reactome





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