Gene description for PON3
Gene name paraoxonase 3
Gene symbol PON3
Other names/aliases -
Species Homo sapiens
 Database cross references - PON3
ExoCarta ExoCarta_5446
Entrez Gene 5446
HGNC 9206
MIM 602720
UniProt Q15166  
 PON3 identified in exosomes derived from the following tissue/cell type
Saliva 19199708    
 Gene ontology annotations for PON3
Molecular Function
    3,4-dihydrocoumarin hydrolase activity GO:0018733 IEA
    dihydrocoumarin hydrolase activity GO:0047856 IEA
    aryldialkylphosphatase activity GO:0004063 IEA
    arylesterase activity GO:0004064 NAS
    metal ion binding GO:0046872 IEA
    protein homodimerization activity GO:0042803 IDA
Biological Process
    dephosphorylation GO:0016311 IEA
    response to external stimulus GO:0009605 NAS
    phenylacetate catabolic process GO:0010124 IEA
    aromatic compound catabolic process GO:0019439 IDA
    carboxylic acid catabolic process GO:0046395 IDA
    coumarin catabolic process GO:0046226 IEA
Subcellular Localization
    intracellular membrane-bounded organelle GO:0043231 IEA
    extracellular exosome GO:0070062 IDA
    extracellular space GO:0005615 IEA
 Experiment description of studies that identified PON3 in exosomes
1
Experiment ID 66
ISEV standards
IEM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
CD63|CD81
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19199708    
Organism Homo sapiens
Experiment description Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).
Authors Gonzalez-Begne M, Lu B, Han X, Hagen FK, Hand AR, Melvin JE, Yates JR
Journal name JPR
Publication year 2009
Sample Saliva
Sample name Saliva
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
Immunoelectron Microscopy
 Protein-protein interactions for PON3
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which PON3 is involved
No pathways found





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