Gene description for PON1
Gene name
paraoxonase 1
Gene symbol
PON1
Other names/aliases
ESA MVCD5 PON
Species
Homo sapiens
Database cross references - PON1
ExoCarta
ExoCarta_5444
Vesiclepedia
VP_5444
Entrez Gene
5444
HGNC
9204
MIM
168820
UniProt
P27169
PON1 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells
36408942
Plasma
19028452
Platelets
25332113
Platelets
25332113
Platelets
25332113
Gene ontology annotations for PON1
Experiment description of studies that identified PON1 in exosomes
1
Experiment ID
488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule
Protein
Identification method
Mass spectrometry
PubMed ID
36408942
Organism
Homo sapiens
Experiment description
Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors
"Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name
Proteomics
Publication year
2023
Sample
Mesenchymal stem cells
Sample name
UCMSC
Isolation/purification methods
Differential centrifugation Filtration Ultracentrifugation
Flotation density
-
Molecules identified in the study
Protein
Methods used in the study
Western blotting Mass spectometry
2
Experiment ID
44
MISEV standards
✔
IEM
Biophysical techniques
✘
Enriched markers
✘
Negative markers
✘
Particle analysis
Identified molecule
protein
Identification method
Mass spectrometry
PubMed ID
19028452
Organism
Homo sapiens
Experiment description
Proteomic profiling of human plasma exosomes identifies PPARgamma as an exosome-associated protein.
Authors
"Looze C, Yui D, Leung L, Ingham M, Kaler M, Yao X, Wu WW, Shen RF, Daniels MP, Levine SJ"
Journal name
BBRC
Publication year
2009
Sample
Plasma
Sample name
Plasma
Isolation/purification methods
Filtration Size exclusion Sucrose density gradient
Flotation density
1.15-1.16 g/mL
Molecules identified in the study
Protein
Methods used in the study
Mass spectrometry [LTQ] Western blotting Immunoelectron Microscopy
3
Experiment ID
231
MISEV standards
✘
Biophysical techniques
✔
Alix|CD63|CD9
Enriched markers
✘
Negative markers
✔
NTA
Particle analysis
Identified molecule
protein
Identification method
Mass spectrometry
PubMed ID
25332113
Organism
Homo sapiens
Experiment description
Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors
"Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name
Transfusion
Publication year
2015
Sample
Platelets
Sample name
PL-Exs - Rep 1
Isolation/purification methods
Differential centrifugation Filtration Ultracentrifugation Optiprep density gradient
Flotation density
1.12-1.15 g/mL
Molecules identified in the study
Protein Lipids
Methods used in the study
Western blotting Mass spectrometry
4
Experiment ID
232
MISEV standards
✘
Biophysical techniques
✘
Enriched markers
✘
Negative markers
✘
Particle analysis
Identified molecule
protein
Identification method
Mass spectrometry
PubMed ID
25332113
Organism
Homo sapiens
Experiment description
Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors
"Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name
Transfusion
Publication year
2015
Sample
Platelets
Sample name
PL-Exs - Rep 2
Isolation/purification methods
Differential centrifugation Filtration Ultracentrifugation Optiprep density gradient
Flotation density
1.12-1.15 g/mL
Molecules identified in the study
Protein
Methods used in the study
Mass spectrometry
5
Experiment ID
233
MISEV standards
✘
Biophysical techniques
✘
Enriched markers
✘
Negative markers
✘
Particle analysis
Identified molecule
protein
Identification method
Mass spectrometry
PubMed ID
25332113
Organism
Homo sapiens
Experiment description
Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors
"Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name
Transfusion
Publication year
2015
Sample
Platelets
Sample name
PL-Exs - Rep 3
Isolation/purification methods
Differential centrifugation Filtration Ultracentrifugation Optiprep density gradient
Flotation density
1.12-1.15 g/mL
Molecules identified in the study
Protein
Methods used in the study
Mass spectrometry
Protein-protein interactions for PON1
Protein Interactor
ExoCarta ID
Identification method
PubMed
Species
1
CDK1
983
Biochemical Activity
Homo sapiens
2
RDH13
Affinity Capture-MS
Homo sapiens
Affinity Capture-MS
Homo sapiens
3
MICU2
221154
Affinity Capture-MS
Homo sapiens
Affinity Capture-MS
Homo sapiens
4
NFYC
4802
Affinity Capture-MS
Homo sapiens
Affinity Capture-MS
Homo sapiens
5
PON3
5446
Affinity Capture-MS
Homo sapiens
Affinity Capture-MS
Homo sapiens
6
MATN2
4147
Affinity Capture-MS
Homo sapiens
7
NDUFB6
4712
Affinity Capture-MS
Homo sapiens
8
KLK10
5655
Affinity Capture-MS
Homo sapiens
9
FANCD2
Affinity Capture-MS
Homo sapiens
10
TRIM21
6737
Affinity Capture-MS
Homo sapiens
11
SFXN5
Affinity Capture-MS
Homo sapiens
Affinity Capture-MS
Homo sapiens
12
CLU
1191
Affinity Capture-Western
Homo sapiens
13
UBE2U
Affinity Capture-MS
Homo sapiens
14
PLK1
5347
Reconstituted Complex
Homo sapiens
Co-crystal Structure
Homo sapiens
Biochemical Activity
Homo sapiens
15
PHF11
51131
Affinity Capture-MS
Homo sapiens
View the network
image/svg+xml
Pathways in which PON1 is involved