Gene description for CSPG5
Gene name chondroitin sulfate proteoglycan 5 (neuroglycan C)
Gene symbol CSPG5
Other names/aliases NGC
Species Homo sapiens
 Database cross references - CSPG5
ExoCarta ExoCarta_10675
Entrez Gene 10675
HGNC 2467
MIM 606775
UniProt O95196  
 CSPG5 identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for CSPG5
Molecular Function
    protein binding GO:0005515 IPI
    growth factor activity GO:0008083 TAS
Biological Process
    nervous system development GO:0007399 TAS
    small molecule metabolic process GO:0044281 TAS
    chondroitin sulfate biosynthetic process GO:0030206 TAS
    axon regeneration GO:0031103 IEA
    regulation of growth GO:0040008 IEA
    regulation of synaptic transmission GO:0050804 IEA
    chondroitin sulfate metabolic process GO:0030204 TAS
    positive regulation of defense response to virus by host GO:0002230 IMP
    chondroitin sulfate catabolic process GO:0030207 TAS
    glycosaminoglycan metabolic process GO:0030203 TAS
    intracellular transport GO:0046907 TAS
    activation of mitophagy in response to mitochondrial depolarization GO:0098779 IMP
    carbohydrate metabolic process GO:0005975 TAS
    dermatan sulfate biosynthetic process GO:0030208 TAS
Subcellular Localization
    lysosomal lumen GO:0043202 TAS
    Golgi apparatus GO:0005794 IDA
    extracellular region GO:0005576 TAS
    endoplasmic reticulum membrane GO:0005789 IEA
    integral component of plasma membrane GO:0005887 TAS
    Golgi lumen GO:0005796 TAS
    membrane GO:0016020 TAS
    integral component of membrane GO:0016021 TAS
    Golgi-associated vesicle membrane GO:0030660 IDA
 Experiment description of studies that identified CSPG5 in exosomes
1
Experiment ID 211
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
EpCAM|TFRC
EV Membrane markers
cytochrome c|GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
ISEV standards
CEM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
EpCAM|TFRC
EV Membrane markers
Cytochrome C|GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for CSPG5
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 GOPC  
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
View the network image/svg+xml



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here