Gene description for C1GALT1
Gene name core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1
Gene symbol C1GALT1
Other names/aliases C1GALT
T-synthase
Species Homo sapiens
 Database cross references - C1GALT1
ExoCarta ExoCarta_56913
Entrez Gene 56913
HGNC 24337
MIM 610555
UniProt Q9NS00  
 C1GALT1 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for C1GALT1
Molecular Function
    metal ion binding GO:0046872 IEA
    protein binding GO:0005515 IPI
    glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity GO:0016263 IDA
Biological Process
    kidney development GO:0001822 IMP
    cellular protein metabolic process GO:0044267 TAS
    O-glycan processing GO:0016266 TAS
    protein O-linked glycosylation GO:0006493 TAS
    angiogenesis GO:0001525 IMP
    intestinal epithelial cell development GO:0060576 IEA
    post-translational protein modification GO:0043687 TAS
Subcellular Localization
    Golgi membrane GO:0000139 TAS
    integral component of membrane GO:0016021 IDA
 Experiment description of studies that identified C1GALT1 in exosomes
1
Experiment ID 237
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
✘ EV Membrane markers
✔
HSP90B1
EV Negative markers
✔
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for C1GALT1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which C1GALT1 is involved
PathwayEvidenceSource
O-linked glycosylation of mucins TAS Reactome





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here