Gene description for PTDSS2
Gene name phosphatidylserine synthase 2
Gene symbol PTDSS2
Other names/aliases PSS2
Species Homo sapiens
 Database cross references - PTDSS2
ExoCarta ExoCarta_81490
Vesiclepedia VP_81490
Entrez Gene 81490
HGNC 15463
MIM 612793
UniProt Q9BVG9  
 PTDSS2 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for PTDSS2
Molecular Function
    CDP-diacylglycerol-serine O-phosphatidyltransferase activity GO:0003882 IEA
    transferase activity GO:0016740 TAS
    L-serine-phosphatidylethanolamine phosphatidyltransferase activity GO:0106245 IDA
Biological Process
    phosphatidylserine biosynthetic process GO:0006659 IDA
    phosphatidylserine biosynthetic process GO:0006659 IEA
    phosphatidylserine biosynthetic process GO:0006659 TAS
Subcellular Localization
    endoplasmic reticulum membrane GO:0005789 ISS
    endoplasmic reticulum membrane GO:0005789 TAS
    membrane GO:0016020 ISS
 Experiment description of studies that identified PTDSS2 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for PTDSS2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 STARD3NL 83930
Affinity Capture-MS Homo sapiens
2 F2RL1  
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
3 HMOX1 3162
Affinity Capture-MS Homo sapiens
4 RAMP3  
Affinity Capture-MS Homo sapiens
5 H2AFJ 55766
Affinity Capture-MS Homo sapiens
6 CDS2 8760
Affinity Capture-MS Homo sapiens
7 HIST1H2AJ 8331
Affinity Capture-MS Homo sapiens
8 P2RY2 5029
Affinity Capture-MS Homo sapiens
9 VIPR2  
Affinity Capture-MS Homo sapiens
10 ADORA2B  
Affinity Capture-MS Homo sapiens
11 TACR1  
Affinity Capture-MS Homo sapiens
12 FPR2  
Affinity Capture-MS Homo sapiens
13 AHSA1 10598
Affinity Capture-MS Homo sapiens
14 ILF3 3609
Co-fractionation Homo sapiens
15 TP53 7157
Affinity Capture-MS Homo sapiens
16 DRD3  
Affinity Capture-MS Homo sapiens
17 CLPP 8192
Proximity Label-MS Homo sapiens
18 LRRC25  
Affinity Capture-MS Homo sapiens
19 HSP90AA1 3320
Affinity Capture-MS Homo sapiens
20 ENTPD7  
Affinity Capture-MS Homo sapiens
21 CLEC2D  
Affinity Capture-MS Homo sapiens
22 CD70 970
Affinity Capture-MS Homo sapiens
23 B3GNT3 10331
Affinity Capture-MS Homo sapiens
24 CMKLR1 1240
Affinity Capture-MS Homo sapiens
25 HS2ST1 9653
Affinity Capture-MS Homo sapiens
26 TSPAN15 23555
Affinity Capture-MS Homo sapiens
27 MBOAT1  
Affinity Capture-MS Homo sapiens
28 HSP90AB1 3326
Affinity Capture-MS Homo sapiens
29 FKBP4 2288
Affinity Capture-MS Homo sapiens
30 EDNRA 1909
Affinity Capture-MS Homo sapiens
31 HNRNPR 10236
Co-fractionation Homo sapiens
32 TMEM72  
Affinity Capture-MS Homo sapiens
33 AMFR 267
Affinity Capture-MS Homo sapiens
34 OPRL1 4987
Affinity Capture-MS Homo sapiens
35 P2RY8  
Affinity Capture-MS Homo sapiens
36 FFAR1  
Affinity Capture-MS Homo sapiens
37 LPAR1 1902
Affinity Capture-MS Homo sapiens
38 GPR173  
Affinity Capture-MS Homo sapiens
39 URI1  
Affinity Capture-MS Homo sapiens
40 GPR35  
Affinity Capture-MS Homo sapiens
41 SYP  
Affinity Capture-MS Homo sapiens
42 PIGN 23556
Affinity Capture-MS Homo sapiens
43 FKBP5 2289
Affinity Capture-MS Homo sapiens
44 B3GALT4  
Affinity Capture-MS Homo sapiens
45 AQP3  
Affinity Capture-MS Homo sapiens
46 GP5 2814
Affinity Capture-MS Homo sapiens
47 FAM134C 162427
Affinity Capture-MS Homo sapiens
48 NUDC 10726
Affinity Capture-MS Homo sapiens
49 SPPL2B 56928
Affinity Capture-MS Homo sapiens
50 S1PR1 1901
Affinity Capture-MS Homo sapiens
51 GPR45  
Affinity Capture-MS Homo sapiens
52 P2RY1  
Affinity Capture-MS Homo sapiens
53 ACKR2  
Affinity Capture-MS Homo sapiens
54 GPR182  
Affinity Capture-MS Homo sapiens
55 LPAR2 9170
Affinity Capture-MS Homo sapiens
56 KCNK1  
Affinity Capture-MS Homo sapiens
57 ASIC4  
Affinity Capture-MS Homo sapiens
58 APLNR  
Affinity Capture-MS Homo sapiens
59 STOM 2040
Affinity Capture-MS Homo sapiens
60 MARCH8  
Affinity Capture-MS Homo sapiens
61 VIPR1  
Affinity Capture-MS Homo sapiens
62 P2RX2  
Affinity Capture-MS Homo sapiens
63 TMEM63A 9725
Affinity Capture-MS Homo sapiens
64 TMEM184A  
Affinity Capture-MS Homo sapiens
65 CCR6  
Affinity Capture-MS Homo sapiens
66 RPAP3 79657
Affinity Capture-MS Homo sapiens
67 SLC1A1 6505
Affinity Capture-MS Homo sapiens
68 SLC22A4 6583
Affinity Capture-MS Homo sapiens
69 ENTPD2 954
Affinity Capture-MS Homo sapiens
70 CCDC47 57003
Affinity Capture-MS Homo sapiens
71 DUSP23 54935
Affinity Capture-MS Homo sapiens
72 ADGRE5 976
Affinity Capture-MS Homo sapiens
73 KIAA1644  
Affinity Capture-MS Homo sapiens
74 P2RY12 64805
Affinity Capture-MS Homo sapiens
75 S1PR4  
Affinity Capture-MS Homo sapiens
76 GPR55  
Affinity Capture-MS Homo sapiens
77 MRGPRX4  
Affinity Capture-MS Homo sapiens
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