Gene description for EDNRA
Gene name endothelin receptor type A
Gene symbol EDNRA
Other names/aliases ET-A
ETA
ETA-R
ETAR
ETRA
hET-AR
Species Homo sapiens
 Database cross references - EDNRA
ExoCarta ExoCarta_1909
Vesiclepedia VP_1909
Entrez Gene 1909
HGNC 3179
MIM 131243
UniProt P25101  
 EDNRA identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for EDNRA
Molecular Function
    phosphatidylinositol phospholipase C activity GO:0004435 TAS
    endothelin receptor activity GO:0004962 IBA
    endothelin receptor activity GO:0004962 NAS
    protein binding GO:0005515 IPI
Biological Process
    mitotic cell cycle GO:0000278 IEA
    branching involved in blood vessel morphogenesis GO:0001569 IEA
    response to hypoxia GO:0001666 IEA
    in utero embryonic development GO:0001701 IEA
    blood vessel remodeling GO:0001974 IEA
    response to amphetamine GO:0001975 IEA
    regulation of heart rate GO:0002027 IEA
    glomerular filtration GO:0003094 IEA
    cardiac chamber formation GO:0003207 IEA
    left ventricular cardiac muscle tissue morphogenesis GO:0003220 IEA
    atrial cardiac muscle tissue development GO:0003228 IEA
    cardiac neural crest cell migration involved in outflow tract morphogenesis GO:0003253 IEA
    noradrenergic neuron differentiation GO:0003357 IEA
    intracellular calcium ion homeostasis GO:0006874 IDA
    smooth muscle contraction GO:0006939 NAS
    mitochondrion organization GO:0007005 IEA
    signal transduction GO:0007165 TAS
    G protein-coupled receptor signaling pathway GO:0007186 NAS
    activation of adenylate cyclase activity GO:0007190 TAS
    adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway GO:0007193 IEA
    phospholipase C-activating G protein-coupled receptor signaling pathway GO:0007200 TAS
    positive regulation of cytosolic calcium ion concentration GO:0007204 TAS
    respiratory gaseous exchange by respiratory system GO:0007585 ISS
    regulation of blood pressure GO:0008217 IEA
    cell population proliferation GO:0008283 TAS
    response to wounding GO:0009611 IEA
    gene expression GO:0010467 IEA
    regulation of D-glucose transmembrane transport GO:0010827 IEA
    neural crest cell fate commitment GO:0014034 IEA
    artery smooth muscle contraction GO:0014824 IMP
    neuron remodeling GO:0016322 IEA
    heparin metabolic process GO:0030202 IEA
    thyroid gland development GO:0030878 IEA
    cellular response to oxidative stress GO:0034599 IEA
    embryonic heart tube development GO:0035050 IEA
    aorta development GO:0035904 IEA
    vasoconstriction GO:0042310 IBA
    vasoconstriction GO:0042310 IMP
    norepinephrine metabolic process GO:0042415 IEA
    middle ear morphogenesis GO:0042474 IEA
    positive regulation of canonical NF-kappaB signal transduction GO:0043123 IEA
    cellular response to human chorionic gonadotropin stimulus GO:0044751 IEA
    developmental pigmentation GO:0048066 IBA
    enteric nervous system development GO:0048484 IEA
    sympathetic nervous system development GO:0048485 IEA
    axon extension GO:0048675 IEA
    embryonic skeletal system development GO:0048706 IEA
    neuromuscular process GO:0050905 IEA
    sodium ion homeostasis GO:0055078 IEA
    canonical Wnt signaling pathway GO:0060070 IEA
    face development GO:0060324 IEA
    axonogenesis involved in innervation GO:0060385 IEA
    establishment of endothelial barrier GO:0061028 IEA
    pharyngeal arch artery morphogenesis GO:0061626 IEA
    renal sodium ion absorption GO:0070294 IEA
    calcium ion transmembrane transport GO:0070588 IEA
    cellular response to follicle-stimulating hormone stimulus GO:0071372 IEA
    cellular response to luteinizing hormone stimulus GO:0071373 IEA
    protein transmembrane transport GO:0071806 IEA
    glomerular endothelium development GO:0072011 IEA
    podocyte differentiation GO:0072112 IEA
    endothelin receptor signaling pathway GO:0086100 IBA
    endothelin receptor signaling pathway involved in heart process GO:0086101 IEA
    renal albumin absorption GO:0097018 IEA
    vascular associated smooth muscle cell development GO:0097084 IEA
    mesenchymal cell apoptotic process GO:0097152 IEA
    sympathetic neuron axon guidance GO:0097492 IEA
    cAMP/PKA signal transduction GO:0141156 IDA
    semaphorin-plexin signaling pathway involved in axon guidance GO:1902287 IEA
    podocyte apoptotic process GO:1903210 IEA
    meiotic cell cycle process involved in oocyte maturation GO:1903537 IEA
    cranial skeletal system development GO:1904888 IEA
    response to acetylcholine GO:1905144 IEA
    regulation of protein localization to cell leading edge GO:1905871 IEA
    positive regulation of cation channel activity GO:2001259 IDA
Subcellular Localization
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 TAS
 Experiment description of studies that identified EDNRA in exosomes
1
Experiment ID 489
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for EDNRA
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 MBOAT7 79143
Affinity Capture-MS Homo sapiens
2 ARRB1 408
Affinity Capture-Western Homo sapiens
3 ARRB2 409
Affinity Capture-Western Homo sapiens
4 COX1 4512
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 SYNGR2 9144
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 KDELR1 10945
Affinity Capture-MS Homo sapiens
7 OXA1L  
Affinity Capture-MS Homo sapiens
8 TMEM87A 25963
Affinity Capture-MS Homo sapiens
9 AGPAT9  
Affinity Capture-MS Homo sapiens
10 ATP1A3 478
Affinity Capture-MS Homo sapiens
11 ANKRD13A 88455
Affinity Capture-MS Homo sapiens
12 PTDSS2 81490
Affinity Capture-MS Homo sapiens
13 MTX1 4580
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 PXMP2  
Affinity Capture-MS Homo sapiens
15 EDN1  
Reconstituted Complex Homo sapiens
16 LPHN1  
Affinity Capture-MS Homo sapiens
17 MCL1 4170
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 VKORC1L1 154807
Affinity Capture-MS Homo sapiens
19 ENDOD1 23052
Affinity Capture-MS Homo sapiens
20 BCL2L11  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 LMBR1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 UNC93B1 81622
Affinity Capture-MS Homo sapiens
23 PIGU 128869
Affinity Capture-MS Homo sapiens
24 REEP4  
Affinity Capture-MS Homo sapiens
25 EBP  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 TMEM126A 84233
Affinity Capture-MS Homo sapiens
27 XPO5 57510
Affinity Capture-MS Homo sapiens
28 TMBIM6 7009
Affinity Capture-MS Homo sapiens
29 MTX2 10651
Affinity Capture-MS Homo sapiens
30 GNA11 2767
Affinity Capture-Western Homo sapiens
31 HDAC7  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
32 ARL5B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
33 SLC25A4 291
Affinity Capture-MS Homo sapiens
34 C16orf58 64755
Affinity Capture-MS Homo sapiens
35 ND1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
36 MGST3 4259
Affinity Capture-MS Homo sapiens
37 CAV2 858
Affinity Capture-MS Homo sapiens
38 SLC30A7 148867
Affinity Capture-MS Homo sapiens
39 KAT5  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
40 COPS5 10987
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
41 SMPD2 6610
Affinity Capture-MS Homo sapiens
42 MPDU1 9526
Affinity Capture-MS Homo sapiens
43 SRC 6714
Affinity Capture-Western Homo sapiens
44 IFITM3 10410
Affinity Capture-MS Homo sapiens
45 RNF185  
Affinity Capture-MS Homo sapiens
46 SLC5A3 6526
Affinity Capture-MS Homo sapiens
47 KDELR2 11014
Affinity Capture-MS Homo sapiens
48 VPS11 55823
Co-purification Homo sapiens
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