Gene description for EDNRA
Gene name endothelin receptor type A
Gene symbol EDNRA
Other names/aliases ET-A
ETA
ETA-R
ETAR
ETRA
hET-AR
Species Homo sapiens
 Database cross references - EDNRA
ExoCarta ExoCarta_1909
Vesiclepedia VP_1909
Entrez Gene 1909
HGNC 3179
MIM 131243
UniProt P25101  
 EDNRA identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for EDNRA
Molecular Function
    phosphatidylinositol phospholipase C activity GO:0004435 TAS
    protein binding GO:0005515 IPI
    endothelin receptor activity GO:0004962 NAS
Biological Process
    penile erection GO:0043084 IEA
    negative regulation of cAMP biosynthetic process GO:0030818 IEA
    positive regulation of cell proliferation GO:0008284 IEA
    positive regulation of kidney development GO:0090184 IEA
    neural crest cell development GO:0014032 IEA
    response to lipopolysaccharide GO:0032496 IEA
    enteric nervous system development GO:0048484 IEA
    heart development GO:0007507 IEA
    glucose transport GO:0015758 ISS
    positive regulation of inflammatory response GO:0050729 IEA
    patterning of blood vessels GO:0001569 IEA
    regulation of epithelial cell proliferation GO:0050678 IEA
    smooth muscle contraction GO:0006939 NAS
    cell proliferation GO:0008283 NAS
    in utero embryonic development GO:0001701 IEA
    protein kinase C-activating G-protein coupled receptor signaling pathway GO:0007205 IEA
    negative regulation of apoptotic process GO:0043066 IEA
    response to morphine GO:0043278 IEA
    positive regulation of release of sequestered calcium ion into cytosol GO:0051281 IEA
    sensory perception of pain GO:0019233 IEA
    Rho protein signal transduction GO:0007266 IEA
    histamine secretion GO:0001821 IEA
    artery smooth muscle contraction GO:0014824 IMP
    respiratory gaseous exchange GO:0007585 ISS
    G-protein coupled receptor signaling pathway GO:0007186 NAS
    activation of phospholipase C activity GO:0007202 TAS
    positive regulation of neutrophil chemotaxis GO:0090023 IEA
    metabolic process GO:0008152 TAS
    response to hypoxia GO:0001666 IEA
    regulation of blood pressure GO:0008217 IEA
    positive regulation of odontogenesis GO:0042482 IEA
    positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway GO:0051482 IEA
    activation of adenylate cyclase activity GO:0007190 TAS
    cellular response to mechanical stimulus GO:0071260 IEA
    glomerular filtration GO:0003094 IEA
    endothelin receptor signaling pathway GO:0086100 NAS
    vasoconstriction GO:0042310 IMP
    maternal process involved in parturition GO:0060137 IEA
    aging GO:0007568 IEA
    signal transduction GO:0007165 TAS
    fibroblast proliferation GO:0048144 IEA
    smooth muscle cell proliferation GO:0048659 IEA
    positive regulation of ERK1 and ERK2 cascade GO:0070374 IEA
    positive regulation of cytosolic calcium ion concentration GO:0007204 TAS
    head development GO:0060322 IEA
Subcellular Localization
    membrane raft GO:0045121 IEA
    nuclear membrane GO:0031965 IEA
    integral component of plasma membrane GO:0005887 TAS
    plasma membrane GO:0005886 TAS
    T-tubule GO:0030315 IEA
    cytosol GO:0005829 TAS
 Experiment description of studies that identified EDNRA in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for EDNRA
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 EDN1  
Invivo Homo sapiens
Affinity Capture-MS Homo sapiens
2 EDN3  
Invivo Homo sapiens
Invitro Homo sapiens
Affinity Capture-MS Homo sapiens
3 HTATIP  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
4 GNA11 2767
Invitro Homo sapiens
Affinity Capture-MS Homo sapiens
5 HDAC7A  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
6 GRK6 2870
Affinity Capture-MS Homo sapiens
7 GNAI2 2771
Invivo Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which EDNRA is involved
PathwayEvidenceSource
G alpha (q) signalling events TAS Reactome
G alpha (q) signalling events TAS Reactome
Peptide ligand-binding receptors TAS Reactome





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