Gene description for BMP15
Gene name bone morphogenetic protein 15
Gene symbol BMP15
Other names/aliases GDF9B
ODG2
POF4
Species Homo sapiens
 Database cross references - BMP15
ExoCarta ExoCarta_9210
Entrez Gene 9210
HGNC 1068
MIM 300247
UniProt O95972  
 BMP15 identified in exosomes derived from the following tissue/cell type
Squamous carcinoma cells 20124223    
 Gene ontology annotations for BMP15
Molecular Function
    transforming growth factor beta receptor binding GO:0005160 IBA
    cytokine activity GO:0005125 IBA
    growth factor activity GO:0008083 IEA
Biological Process
    BMP signaling pathway GO:0030509 IBA
    positive regulation of transcription, DNA-templated GO:0045893 IEA
    regulation of MAPK cascade GO:0043408 IBA
    SMAD protein signal transduction GO:0060395 IBA
    cell development GO:0048468 IBA
    female gamete generation GO:0007292 TAS
    granulosa cell development GO:0060016 IEA
    ovarian follicle development GO:0001541 IEA
    regulation of apoptotic process GO:0042981 IBA
    positive regulation of pathway-restricted SMAD protein phosphorylation GO:0010862 IBA
Subcellular Localization
    extracellular space GO:0005615 IBA
    cytoplasm GO:0005737 IEA
 Experiment description of studies that identified BMP15 in exosomes
1
Experiment ID 191
ISEV standards
✘ EV Biophysical techniques
✔
Alix
EV Cytosolic markers
✔
CD81|CD9
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20124223    
Organism Homo sapiens
Experiment description Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of proteins and exosomes.
Authors Park JE, Tan HS, Datta A, Lai RC, Zhang H, Meng W, Lim SK, Sze SK.
Journal name Mol Cell Proteomics
Publication year 2010
Sample Squamous carcinoma cells
Sample name Squamous carcinoma cell (A431)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for BMP15
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which BMP15 is involved
No pathways found





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