Gene description for LRRK1
Gene name leucine-rich repeat kinase 1
Gene symbol LRRK1
Other names/aliases RIPK6
Roco1
Species Homo sapiens
 Database cross references - LRRK1
ExoCarta ExoCarta_79705
Vesiclepedia VP_79705
Entrez Gene 79705
HGNC 18608
MIM 610986
UniProt Q38SD2  
 LRRK1 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for LRRK1
Molecular Function
    identical protein binding GO:0042802 IPI
    ATP binding GO:0005524 IEA
    metal ion binding GO:0046872 IEA
    protein serine/threonine kinase activity GO:0004674 IEA
    protein binding GO:0005515 IPI
    GTP binding GO:0005525 IEA
Biological Process
    small GTPase mediated signal transduction GO:0007264 IEA
    positive regulation of intracellular signal transduction GO:1902533 IEA
    bone resorption GO:0045453 IEA
    protein phosphorylation GO:0006468 IEA
    osteoclast development GO:0036035 IEA
    positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 IEA
    negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 IEA
Subcellular Localization
    mitochondrion GO:0005739 IDA
    cytoplasm GO:0005737 IDA
 Experiment description of studies that identified LRRK1 in exosomes
1
Experiment ID 488
MISEV standards
✔
EM
EV Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
EV Enriched markers
✔
CANX
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for LRRK1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 RIMS1  
Affinity Capture-MS Homo sapiens
2 LYZ 4069
Affinity Capture-MS Homo sapiens
3 C9ORF163  
Affinity Capture-MS Homo sapiens
4 PAK4 10298
Affinity Capture-MS Homo sapiens
5 S100A8 6279
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which LRRK1 is involved
No pathways found





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