Gene description for LRRK1
Gene name leucine-rich repeat kinase 1
Gene symbol LRRK1
Other names/aliases RIPK6
Roco1
Species Homo sapiens
 Database cross references - LRRK1
ExoCarta ExoCarta_79705
Vesiclepedia VP_79705
Entrez Gene 79705
HGNC 18608
MIM 610986
UniProt Q38SD2  
 LRRK1 identified in sEVs derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for LRRK1
Molecular Function
    protein serine/threonine kinase activity GO:0004674 IBA
    3-phosphoinositide-dependent protein kinase activity GO:0004676 IEA
    DNA-dependent protein kinase activity GO:0004677 IEA
    AMP-activated protein kinase activity GO:0004679 IEA
    eukaryotic translation initiation factor 2alpha kinase activity GO:0004694 IEA
    ribosomal protein S6 kinase activity GO:0004711 IEA
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    GTP binding GO:0005525 IEA
    histone H3S10 kinase activity GO:0035175 IEA
    histone H3T11 kinase activity GO:0035402 IEA
    histone H3T6 kinase activity GO:0035403 IEA
    histone H2AXS139 kinase activity GO:0035979 IEA
    identical protein binding GO:0042802 IPI
    histone H3S28 kinase activity GO:0044022 IEA
    histone H4S1 kinase activity GO:0044023 IEA
    histone H2AS1 kinase activity GO:0044024 IEA
    histone H2BS14 kinase activity GO:0044025 IEA
    metal ion binding GO:0046872 IEA
    histone H3T3 kinase activity GO:0072354 IEA
    histone H2AS121 kinase activity GO:0072371 IEA
    Rho-dependent protein serine/threonine kinase activity GO:0072518 IEA
    protein serine kinase activity GO:0106310 IEA
    histone H2BS36 kinase activity GO:0140823 IEA
    histone H3S57 kinase activity GO:0140855 IEA
    histone H3T45 kinase activity GO:0140857 IEA
    histone H2AT120 kinase activity GO:1990244 IEA
Biological Process
    chromatin remodeling GO:0006338 IEA
    intracellular signal transduction GO:0035556 IEA
    osteoclast development GO:0036035 IEA
    bone resorption GO:0045453 IEA
    positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 IEA
    positive regulation of canonical Wnt signaling pathway GO:0090263 IGI
    positive regulation of intracellular signal transduction GO:1902533 IEA
Subcellular Localization
    mitochondrion GO:0005739 IDA
    cytosol GO:0005829 IDA
    plasma membrane GO:0005886 IEA
 Experiment description of studies that identified LRRK1 in sEVs
1
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for LRRK1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PTPN11 5781
Affinity Capture-MS Homo sapiens
2 LYZ 4069
Affinity Capture-MS Homo sapiens
3 RIMS1  
Affinity Capture-MS Homo sapiens
4 NEDD4 4734
Affinity Capture-MS Homo sapiens
5 C9orf163  
Affinity Capture-MS Homo sapiens
6 SHC1 6464
Affinity Capture-MS Homo sapiens
7 VAPA 9218
Affinity Capture-MS Homo sapiens
8 HSPA8 3312
Affinity Capture-Western Homo sapiens
9 CCT2 10576
Affinity Capture-MS Homo sapiens
10 DOK3 79930
Affinity Capture-MS Homo sapiens
11 DAPK1 1612
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
12 SOS1 6654
Affinity Capture-MS Homo sapiens
13 CDC37 11140
Affinity Capture-MS Homo sapiens
14 CUL3 8452
Affinity Capture-MS Homo sapiens
15 SQSTM1 8878
Affinity Capture-Western Homo sapiens
16 ABL1 25
Affinity Capture-MS Homo sapiens
17 EGFR 1956
Affinity Capture-MS Homo sapiens
18 INPPL1 3636
Affinity Capture-MS Homo sapiens
19 NAP1L1 4673
Affinity Capture-MS Homo sapiens
20 GAB2 9846
Affinity Capture-MS Homo sapiens
21 HNRNPK 3190
Affinity Capture-MS Homo sapiens
22 BAG5 9529
Affinity Capture-Western Homo sapiens
23 FKBP5 2289
Affinity Capture-MS Homo sapiens
24 LRRK1 79705
Biochemical Activity Homo sapiens
Co-crystal Structure Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Co-crystal Structure Homo sapiens
Affinity Capture-Western Homo sapiens
25 PPM1B 5495
Co-fractionation Homo sapiens
26 LRRK2 120892
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
27 PAK4 10298
Affinity Capture-MS Homo sapiens
28 HSP90AA1 3320
Affinity Capture-Western Homo sapiens
29 S100A8 6279
Affinity Capture-MS Homo sapiens
30 DNAJA1 3301
Affinity Capture-MS Homo sapiens
31 SOS2 6655
Affinity Capture-MS Homo sapiens
32 INPP5D 3635
Affinity Capture-MS Homo sapiens
33 ASAP1 50807
Affinity Capture-MS Homo sapiens
34 RSU1 6251
Affinity Capture-MS Homo sapiens
35 GRB2 2885
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
36 BCR 613
Affinity Capture-MS Homo sapiens
37 MAP4K1  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which LRRK1 is involved
No pathways found





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