Gene description for MPHOSPH10
Gene name M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein)
Gene symbol MPHOSPH10
Other names/aliases CT90
MPP10
MPP10P
PPP1R106
Species Homo sapiens
 Database cross references - MPHOSPH10
ExoCarta ExoCarta_10199
Vesiclepedia VP_10199
Entrez Gene 10199
HGNC 7213
MIM 605503
UniProt O00566  
 MPHOSPH10 identified in exosomes derived from the following tissue/cell type
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for MPHOSPH10
Molecular Function
    RNA binding GO:0003723 HDA
    protein binding GO:0005515 IPI
Biological Process
    RNA splicing, via transesterification reactions GO:0000375 NAS
    RNA processing GO:0006396 NAS
    RNA splicing GO:0008380 NAS
    maturation of SSU-rRNA GO:0030490 NAS
    ribosomal small subunit biogenesis GO:0042274 IDA
Subcellular Localization
    nucleoplasm GO:0005654 TAS
    chromosome GO:0005694 IDA
    nucleolus GO:0005730 IDA
    nucleolus GO:0005730 NAS
    sno(s)RNA-containing ribonucleoprotein complex GO:0005732 NAS
    small-subunit processome GO:0032040 IBA
    small-subunit processome GO:0032040 IDA
    Mpp10 complex GO:0034457 IBA
    Mpp10 complex GO:0034457 IPI
 Experiment description of studies that identified MPHOSPH10 in exosomes
1
Experiment ID 834
MISEV standards
✔
EM
Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 835
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for MPHOSPH10
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 RPSA 3921
Affinity Capture-MS Homo sapiens
2 SLFN11 91607
Affinity Capture-MS Homo sapiens
3 ZNF668  
Affinity Capture-MS Homo sapiens
4 UTP18  
Co-fractionation Homo sapiens
5 H1FNT  
Affinity Capture-MS Homo sapiens
6 UTP15 84135
Co-fractionation Homo sapiens
7 NOP58 51602
Co-fractionation Homo sapiens
8 AATF  
Co-fractionation Homo sapiens
9 ZNF346  
Affinity Capture-MS Homo sapiens
10 IPO7 10527
Co-fractionation Homo sapiens
11 RIT1 6016
Negative Genetic Homo sapiens
12 RPL13A 23521
Affinity Capture-MS Homo sapiens
13 RPL37A 6168
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 NOP56 10528
Co-fractionation Homo sapiens
Proximity Label-MS Homo sapiens
15 ESF1 51575
Co-fractionation Homo sapiens
16 CHCHD1  
Proximity Label-MS Homo sapiens
17 RPL14 9045
Affinity Capture-MS Homo sapiens
18 CSNK2A1 1457
Biochemical Activity Homo sapiens
19 FGF3  
Affinity Capture-MS Homo sapiens
20 KRI1  
Co-fractionation Homo sapiens
21 DIEXF  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 UTP3 57050
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
23 WDR36 134430
Co-fractionation Homo sapiens
24 RPS3 6188
Affinity Capture-MS Homo sapiens
25 USP36  
Affinity Capture-MS Homo sapiens
26 DDX23 9416
Proximity Label-MS Homo sapiens
27 HIST1H1A 3024
Affinity Capture-MS Homo sapiens
28 KIF23 9493
Affinity Capture-MS Homo sapiens
29 IMP3 55272
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
30 RPS10 6204
Affinity Capture-MS Homo sapiens
31 NPM1 4869
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
32 RPS8 6202
Affinity Capture-MS Homo sapiens
33 FBL 2091
Co-fractionation Homo sapiens
Proximity Label-MS Homo sapiens
34 POLR1E  
Proximity Label-MS Homo sapiens
35 ZNF2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
36 RPS9 6203
Affinity Capture-MS Homo sapiens
37 SRP14 6727
Affinity Capture-MS Homo sapiens
38 ADARB1 104
Affinity Capture-MS Homo sapiens
39 PRKRA 8575
Affinity Capture-MS Homo sapiens
40 DDX18 8886
Co-fractionation Homo sapiens
41 MYCN  
Affinity Capture-MS Homo sapiens
42 CSNK2B 1460
Affinity Capture-MS Homo sapiens
43 RPL19 6143
Affinity Capture-MS Homo sapiens
44 KIF14 9928
Affinity Capture-MS Homo sapiens
45 LIN28A  
Affinity Capture-MS Homo sapiens
46 E2F4  
Affinity Capture-MS Homo sapiens
47 AURKA 6790
Affinity Capture-MS Homo sapiens
48 PPP1CA 5499
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
49 RHOA 387
Affinity Capture-MS Homo sapiens
50 UTP14A 10813
Co-fractionation Homo sapiens
51 DDX21 9188
Cross-Linking-MS (XL-MS) Homo sapiens
52 RPL4 6124
Affinity Capture-MS Homo sapiens
53 NOL6 65083
Co-fractionation Homo sapiens
54 RBM19 9904
Affinity Capture-MS Homo sapiens
55 ZBTB47  
Affinity Capture-MS Homo sapiens
56 RBM4B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
57 YBX2 51087
Affinity Capture-MS Homo sapiens
58 SRSF6 6431
Affinity Capture-MS Homo sapiens
59 NOP2 4839
Co-fractionation Homo sapiens
60 RPL18A 6142
Affinity Capture-MS Homo sapiens
61 FGF8  
Affinity Capture-MS Homo sapiens
62 RPS7 6201
Co-fractionation Homo sapiens
63 IFI16 3428
Affinity Capture-MS Homo sapiens
64 HIST1H1E 3008
Affinity Capture-MS Homo sapiens
65 REXO4  
Affinity Capture-MS Homo sapiens
66 RPL36 25873
Affinity Capture-MS Homo sapiens
67 HIST1H1C 3006
Affinity Capture-MS Homo sapiens
68 LYAR 55646
Affinity Capture-MS Homo sapiens
69 UTP11L  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
70 HECTD1 25831
Affinity Capture-MS Homo sapiens
71 RPLP0 6175
Affinity Capture-MS Homo sapiens
72 MAGEB2 4113
Affinity Capture-MS Homo sapiens
73 RPS15A 6210
Co-fractionation Homo sapiens
74 FGF13  
Affinity Capture-MS Homo sapiens
75 GLTSCR2  
Co-fractionation Homo sapiens
76 HSP90B1 7184
Cross-Linking-MS (XL-MS) Homo sapiens
77 CD3EAP  
Proximity Label-MS Homo sapiens
78 RSL1D1 26156
Affinity Capture-MS Homo sapiens
79 SCARNA22  
Affinity Capture-RNA Homo sapiens
80 ANLN 54443
Affinity Capture-MS Homo sapiens
81 FGFBP1 9982
Affinity Capture-MS Homo sapiens
82 RPS19 6223
Affinity Capture-MS Homo sapiens
83 RPL31 6160
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
84 ABT1 29777
Affinity Capture-MS Homo sapiens
85 RPS2 6187
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
86 SIRT7  
Affinity Capture-MS Homo sapiens
87 RPL35 11224
Affinity Capture-MS Homo sapiens
88 SRSF1 6426
Affinity Capture-MS Homo sapiens
89 NPM3 10360
Affinity Capture-MS Homo sapiens
90 NR3C1 2908
Proximity Label-MS Homo sapiens
91 RPL3 6122
Affinity Capture-MS Homo sapiens
92 EBNA1BP2 10969
Co-fractionation Homo sapiens
93 DDX52  
Co-fractionation Homo sapiens
94 ZC3H10  
Affinity Capture-MS Homo sapiens
95 HIST1H1B 3009
Affinity Capture-MS Homo sapiens
96 DKC1 1736
Co-fractionation Homo sapiens
97 MYC  
Affinity Capture-MS Homo sapiens
98 SART3 9733
Affinity Capture-MS Homo sapiens
99 RPSAP58 388524
Affinity Capture-MS Homo sapiens
100 RNF2  
Affinity Capture-MS Homo sapiens
101 ZC3HAV1 56829
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
102 H2AFB2  
Affinity Capture-MS Homo sapiens
103 RPL11 6135
Affinity Capture-MS Homo sapiens
104 HIST1H1T 3010
Affinity Capture-MS Homo sapiens
105 ZC3H3  
Affinity Capture-MS Homo sapiens
106 PWP2 5822
Co-fractionation Homo sapiens
107 FTSJ3 117246
Co-fractionation Homo sapiens
108 RPS16 6217
Affinity Capture-MS Homo sapiens
109 RPL13 6137
Affinity Capture-MS Homo sapiens
110 SIRT6  
Affinity Capture-MS Homo sapiens
111 PARP1 142
Proximity Label-MS Homo sapiens
112 ILF3 3609
Affinity Capture-MS Homo sapiens
113 RRS1 23212
Affinity Capture-MS Homo sapiens
114 NOL10  
Co-fractionation Homo sapiens
115 DGCR8  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
116 ZNF48  
Affinity Capture-MS Homo sapiens
117 PTBP3 9991
Affinity Capture-MS Homo sapiens
118 TBL3 10607
Co-fractionation Homo sapiens
119 DDX58 23586
Affinity Capture-RNA Homo sapiens
120 MKI67  
Affinity Capture-MS Homo sapiens
121 NIFK 84365
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
122 DHX40  
Proximity Label-MS Homo sapiens
123 C20orf197  
Affinity Capture-MS Homo sapiens
124 KRR1 11103
Affinity Capture-MS Homo sapiens
125 NEIL1  
Affinity Capture-MS Homo sapiens
126 RPS24 6229
Proximity Label-MS Homo sapiens
127 GTPBP4 23560
Co-fractionation Homo sapiens
128 IL17B 27190
Affinity Capture-MS Homo sapiens
129 RPL7A 6130
Affinity Capture-MS Homo sapiens
130 RPS6 6194
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
131 RPL8 6132
Affinity Capture-MS Homo sapiens
132 RPL23A 6147
Affinity Capture-MS Homo sapiens
133 KRAS 3845
Affinity Capture-MS Homo sapiens
Negative Genetic Homo sapiens
134 RPL36AL 6166
Affinity Capture-MS Homo sapiens
135 RC3H1 149041
Affinity Capture-MS Homo sapiens
136 DDX56  
Co-fractionation Homo sapiens
137 HIST1H2AE 3012
Affinity Capture-MS Homo sapiens
138 RPL17 6139
Affinity Capture-MS Homo sapiens
139 IMP4  
Reconstituted Complex Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
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