Gene description for TBL3
Gene name transducin (beta)-like 3
Gene symbol TBL3
Other names/aliases SAZD
UTP13
Species Homo sapiens
 Database cross references - TBL3
ExoCarta ExoCarta_10607
Vesiclepedia VP_10607
Entrez Gene 10607
HGNC 11587
MIM 605915
UniProt Q12788  
 TBL3 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells 36408942    
 Gene ontology annotations for TBL3
Molecular Function
    RNA binding GO:0003723 HDA
    protein binding GO:0005515 IPI
    U3 snoRNA binding GO:0034511 IBA
Biological Process
    endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) GO:0000472 IBA
    endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) GO:0000480 IBA
    ribosomal small subunit biogenesis GO:0042274 IDA
Subcellular Localization
    nucleoplasm GO:0005654 IDA
    nucleoplasm GO:0005654 TAS
    nucleolus GO:0005730 IBA
    nucleolus GO:0005730 IDA
    90S preribosome GO:0030686 IBA
    small-subunit processome GO:0032040 IDA
 Experiment description of studies that identified TBL3 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for TBL3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TGOLN2 10618
Affinity Capture-MS Homo sapiens
2 HSD3B2 3284
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 NOP58 51602
Co-fractionation Homo sapiens
4 LGR4 55366
Affinity Capture-MS Homo sapiens
5 WDR3  
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
6 DNAJC8 22826
Proximity Label-MS Homo sapiens
7 Ruvbl1 56505
Affinity Capture-MS Mus musculus
8 CIB2  
Affinity Capture-MS Homo sapiens
9 KIAA0020 9933
Co-fractionation Homo sapiens
10 NOP56 10528
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
11 HDHD1  
Affinity Capture-MS Homo sapiens
12 KIF20A 10112
Affinity Capture-MS Homo sapiens
13 BAG2 9532
Affinity Capture-MS Homo sapiens
14 Ktn1  
Affinity Capture-MS Mus musculus
15 PWP2 5822
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
16 SOX2  
Affinity Capture-MS Homo sapiens
17 ARNTL  
Affinity Capture-MS Homo sapiens
18 WDR36 134430
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
19 DNAJB6 10049
Proximity Label-MS Homo sapiens
20 USP36  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 C9orf78 51759
Affinity Capture-MS Homo sapiens
22 PARK2  
Affinity Capture-MS Homo sapiens
23 KIF23 9493
Affinity Capture-MS Homo sapiens
24 DDX24 57062
Co-fractionation Homo sapiens
25 MPHOSPH10 10199
Co-fractionation Homo sapiens
26 PRC1 9055
Affinity Capture-MS Homo sapiens
27 NPM1 4869
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 ANOS1 3730
Affinity Capture-MS Homo sapiens
29 FBL 2091
Co-fractionation Homo sapiens
Proximity Label-MS Homo sapiens
30 OBSL1 23363
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
31 RTN1 6252
Affinity Capture-MS Homo sapiens
32 AATF  
Co-fractionation Homo sapiens
33 EXOSC4 54512
Affinity Capture-MS Homo sapiens
34 EED  
Affinity Capture-MS Homo sapiens
35 ATG7 10533
Affinity Capture-MS Homo sapiens
36 DDX18 8886
Co-fractionation Homo sapiens
37 RRP8  
Affinity Capture-MS Homo sapiens
38 SFN 2810
Two-hybrid Homo sapiens
39 KLHL20  
Affinity Capture-MS Homo sapiens
40 SPATA5L1 79029
Affinity Capture-MS Homo sapiens
41 MPHOSPH6 10200
Affinity Capture-MS Homo sapiens
42 KIF14 9928
Affinity Capture-MS Homo sapiens
43 DNASE2B  
Affinity Capture-MS Homo sapiens
44 HIST1H4A 8359
Affinity Capture-MS Homo sapiens
45 RPL4 6124
Affinity Capture-MS Homo sapiens
46 RRP9 9136
Co-fractionation Homo sapiens
47 RBM4B  
Affinity Capture-MS Homo sapiens
48 NOC2L 26155
Co-fractionation Homo sapiens
49 Srp72  
Affinity Capture-MS Mus musculus
50 CHMP4B 128866
Affinity Capture-MS Homo sapiens
51 NTRK1 4914
Affinity Capture-MS Homo sapiens
52 RPL31 6160
Proximity Label-MS Homo sapiens
53 FAIM  
Affinity Capture-MS Homo sapiens
54 IFI16 3428
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
55 PPARD  
Affinity Capture-MS Homo sapiens
56 EXOSC5 56915
Affinity Capture-MS Homo sapiens
57 RPS6 6194
Proximity Label-MS Homo sapiens
58 HECTD1 25831
Affinity Capture-MS Homo sapiens
59 BRD4 23476
Affinity Capture-MS Homo sapiens
60 MAGEB2 4113
Affinity Capture-MS Homo sapiens
61 GTPBP4 23560
Co-fractionation Homo sapiens
62 FAM43A  
Affinity Capture-MS Homo sapiens
63 CHCHD1  
Proximity Label-MS Homo sapiens
64 CD3EAP  
Proximity Label-MS Homo sapiens
65 UTP15 84135
Co-fractionation Homo sapiens
66 SCARNA22  
Affinity Capture-RNA Homo sapiens
67 ANLN 54443
Affinity Capture-MS Homo sapiens
68 GPIHBP1  
Affinity Capture-MS Homo sapiens
69 TUBB 203068
Affinity Capture-MS Homo sapiens
70 UBE2H 7328
Affinity Capture-MS Homo sapiens
71 NOC3L 64318
Co-fractionation Homo sapiens
72 NR3C1 2908
Proximity Label-MS Homo sapiens
73 RC3H2  
Affinity Capture-MS Homo sapiens
74 ECT2 1894
Affinity Capture-MS Homo sapiens
75 SIRT7  
Affinity Capture-MS Homo sapiens
76 KLK11 11012
Affinity Capture-MS Homo sapiens
77 CACNB4  
Two-hybrid Homo sapiens
78 DCAF13 25879
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
79 EGFR 1956
Affinity Capture-MS Homo sapiens
Negative Genetic Homo sapiens
80 ARHGAP25  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
81 DKC1 1736
Co-fractionation Homo sapiens
82 PSPC1 55269
Affinity Capture-MS Homo sapiens
83 RPA3 6119
Proximity Label-MS Homo sapiens
84 DNAJC9 23234
Proximity Label-MS Homo sapiens
85 DDRGK1 65992
Affinity Capture-MS Homo sapiens
86 BRD3 8019
Affinity Capture-MS Homo sapiens
87 FTSJ3 117246
Co-fractionation Homo sapiens
88 C9orf72  
Affinity Capture-MS Homo sapiens
89 RPS16 6217
Affinity Capture-MS Homo sapiens
90 SURF6  
Affinity Capture-MS Homo sapiens
91 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
92 SIRT6  
Affinity Capture-MS Homo sapiens
93 PARP1 142
Proximity Label-MS Homo sapiens
94 TP53 7157
Affinity Capture-MS Homo sapiens
95 POLR1B 84172
Co-fractionation Homo sapiens
96 MNDA 4332
Affinity Capture-MS Homo sapiens
97 DNAJA2 10294
Affinity Capture-MS Homo sapiens
98 ZNF746  
Affinity Capture-MS Homo sapiens
99 CTAG1B  
Affinity Capture-MS Homo sapiens
100 GOLGA7 51125
Affinity Capture-MS Homo sapiens
101 RP2 6102
Affinity Capture-MS Homo sapiens
102 E2F4  
Affinity Capture-MS Homo sapiens
103 MKI67  
Affinity Capture-MS Homo sapiens
104 NIFK 84365
Co-fractionation Homo sapiens
105 WIF1 11197
Affinity Capture-MS Homo sapiens
106 APPBP2  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
107 KRR1 11103
Co-fractionation Homo sapiens
108 RBM4 5936
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
109 ITSN2 50618
Two-hybrid Homo sapiens
110 CHMP4C 92421
Affinity Capture-MS Homo sapiens
111 RPS24 6229
Proximity Label-MS Homo sapiens
112 TECTB  
Affinity Capture-MS Homo sapiens
113 Rrbp1  
Affinity Capture-MS Mus musculus
114 GRSF1 2926
Proximity Label-MS Homo sapiens
115 LDLR 3949
Positive Genetic Homo sapiens
116 CUL7 9820
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
117 KRAS 3845
Negative Genetic Homo sapiens
118 HNRNPU 3192
Affinity Capture-MS Homo sapiens
119 DNAJC17  
Proximity Label-MS Homo sapiens
120 RC3H1 149041
Affinity Capture-MS Homo sapiens
121 EXOSC1 51013
Affinity Capture-MS Homo sapiens
122 DDX56  
Co-fractionation Homo sapiens
123 DKKL1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
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