Gene description for SLC25A13
Gene name solute carrier family 25 (aspartate/glutamate carrier), member 13
Gene symbol SLC25A13
Other names/aliases ARALAR2
CITRIN
CTLN2
Species Homo sapiens
 Database cross references - SLC25A13
ExoCarta ExoCarta_10165
Entrez Gene 10165
HGNC 10983
MIM 603859
UniProt Q9UJS0  
 SLC25A13 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
Mesenchymal stem cells Unpublished / Not applicable
 Gene ontology annotations for SLC25A13
Molecular Function
    L-aspartate transmembrane transporter activity GO:0015183 IDA
    transporter activity GO:0005215 NAS
    calcium ion binding GO:0005509 IDA
    L-glutamate transmembrane transporter activity GO:0005313 IDA
Biological Process
    glucose metabolic process GO:0006006 TAS
    malate-aspartate shuttle GO:0043490 IDA
    transport GO:0006810 NAS
    response to calcium ion GO:0051592 IDA
    small molecule metabolic process GO:0044281 TAS
    aspartate transport GO:0015810 IDA
    carbohydrate metabolic process GO:0005975 TAS
    L-aspartate transmembrane transport GO:0089712 IEA
    L-glutamate transport GO:0015813 IDA
    gluconeogenesis GO:0006094 TAS
    cellular respiration GO:0045333 IDA
    L-glutamate transmembrane transport GO:0089711 IEA
    ATP biosynthetic process GO:0006754 IDA
Subcellular Localization
    integral component of plasma membrane GO:0005887 NAS
    mitochondrion GO:0005739 IDA
    mitochondrial inner membrane GO:0005743 TAS
 Experiment description of studies that identified SLC25A13 in exosomes
1
Experiment ID 237
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
✘ EV Membrane markers
✔
HSP90B1
EV Negative markers
✔
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
2
Experiment ID 126
ISEV standards
✘ EV Biophysical techniques
✔
GAPDH
EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [LTQ-FT Ultra]
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
 Protein-protein interactions for SLC25A13
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which SLC25A13 is involved
PathwayEvidenceSource
Gluconeogenesis TAS Reactome
Mitochondrial protein import TAS Reactome





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