Gene description for SKI
Gene name	SKI proto-oncogene
Gene symbol	SKI
Other names/aliases	SGS SKV
Species	Homo sapiens
Database cross references - SKI
ExoCarta	ExoCarta_6497
Vesiclepedia	VP_6497
Entrez Gene	6497
HGNC	10896
MIM	164780
UniProt	P12755
SKI identified in sEVs derived from the following tissue/cell type
Endothelial cells	26027894
Hepatocellular carcinoma cells	26054723
Hepatocellular carcinoma cells	26054723
Hepatocytes	26054723

Gene ontology annotations for SKI

Molecular Function     RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IBA     DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 IBA     DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0001227 IDA     protein binding GO:0005515 IPI     zinc ion binding GO:0008270 IDA     protein kinase binding GO:0019901 IPI     protein domain specific binding GO:0019904 IPI     ubiquitin protein ligase binding GO:0031625 IPI     identical protein binding GO:0042802 IPI     SMAD binding GO:0046332 IBA     SMAD binding GO:0046332 IPI     histone deacetylase inhibitor activity GO:0046811 ISS     DNA-binding transcription factor binding GO:0140297 IPI Biological Process     negative regulation of transcription by RNA polymerase II GO:0000122 IBA     negative regulation of transcription by RNA polymerase II GO:0000122 IDA     negative regulation of transcription by RNA polymerase II GO:0000122 IMP     neural tube closure GO:0001843 ISS     lens morphogenesis in camera-type eye GO:0002089 ISS     transforming growth factor beta receptor signaling pathway GO:0007179 NAS     negative regulation of cell population proliferation GO:0008285 IDA     anterior/posterior axis specification GO:0009948 ISS     negative regulation of Schwann cell proliferation GO:0010626 IGI     myotube differentiation GO:0014902 IDA     olfactory bulb development GO:0021772 ISS     myelination in peripheral nervous system GO:0022011 ISS     positive regulation of Wnt signaling pathway GO:0030177 NAS     embryonic limb morphogenesis GO:0030326 ISS     negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 IBA     negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 IDA     negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 IGI     negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 IMP     negative regulation of BMP signaling pathway GO:0030514 IBA     negative regulation of BMP signaling pathway GO:0030514 IDA     negative regulation of BMP signaling pathway GO:0030514 IMP     negative regulation of activin receptor signaling pathway GO:0032926 IDA     somatic stem cell population maintenance GO:0035019 ISS     camera-type eye development GO:0043010 ISS     positive regulation of DNA binding GO:0043388 IDA     nose morphogenesis GO:0043585 ISS     negative regulation of osteoblast differentiation GO:0045668 IDA     positive regulation of transcription by RNA polymerase II GO:0045944 ISS     negative regulation of fibroblast proliferation GO:0048147 ISS     camera-type eye morphogenesis GO:0048593 ISS     skeletal muscle fiber development GO:0048741 ISS     cell motility GO:0048870 NAS     roof of mouth development GO:0060021 ISS     cardiac muscle cell proliferation GO:0060038 IEA     retina development in camera-type eye GO:0060041 ISS     face morphogenesis GO:0060325 ISS     bone morphogenesis GO:0060349 ISS     negative regulation of SMAD protein signal transduction GO:0060392 IDA Subcellular Localization     nucleus GO:0005634 IBA     nucleus GO:0005634 IDA     nucleoplasm GO:0005654 IDA     nucleoplasm GO:0005654 TAS     transcription regulator complex GO:0005667 IBA     transcription regulator complex GO:0005667 ISS     cytoplasm GO:0005737 IBA     cytoplasm GO:0005737 ISS     centrosome GO:0005813 IDA     nuclear body GO:0016604 IDA     PML body GO:0016605 IDA     transcription repressor complex GO:0017053 ISS     protein-containing complex GO:0032991 IDA