Gene description for MERTK
Gene name MER proto-oncogene, tyrosine kinase
Gene symbol MERTK
Other names/aliases MER
RP38
Tyro12
c-Eyk
c-mer
Species Homo sapiens
 Database cross references - MERTK
ExoCarta ExoCarta_10461
Vesiclepedia VP_10461
Entrez Gene 10461
HGNC 7027
MIM 604705
UniProt Q12866  
 MERTK identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for MERTK
Molecular Function
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    transmembrane receptor protein tyrosine kinase activity GO:0004714 IEA
Biological Process
    positive regulation of phagocytosis GO:0050766 IDA
    natural killer cell differentiation GO:0001779 IEA
    cell-cell signaling GO:0007267 TAS
    negative regulation of lymphocyte activation GO:0051250 IEA
    cell surface receptor signaling pathway GO:0007166 TAS
    secretion by cell GO:0032940 IEA
    vagina development GO:0060068 IEA
    retina development in camera-type eye GO:0060041 IEA
    negative regulation of leukocyte apoptotic process GO:2000107 IMP
    substrate adhesion-dependent cell spreading GO:0034446 IEA
    phagocytosis GO:0006909 IMP
    blood coagulation GO:0007596 TAS
    apoptotic cell clearance GO:0043277 IEA
    leukocyte migration GO:0050900 TAS
    spermatogenesis GO:0007283 IEA
    platelet activation GO:0030168 IEA
    protein phosphorylation GO:0006468 TAS
    peptidyl-tyrosine phosphorylation GO:0018108 TAS
    protein kinase B signaling GO:0043491 IEA
Subcellular Localization
    integral component of plasma membrane GO:0005887 TAS
    cytoplasm GO:0005737 IDA
    extracellular space GO:0005615 IDA
    photoreceptor outer segment GO:0001750 IEA
    plasma membrane GO:0005886 TAS
    rhabdomere GO:0016028 IDA
 Experiment description of studies that identified MERTK in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for MERTK
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 GAS6 2621
Invitro Homo sapiens
2 GRB2 2885
Invivo Homo sapiens
View the network image/svg+xml
 Pathways in which MERTK is involved
PathwayEvidenceSource
Cell surface interactions at the vascular wall TAS Reactome





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