Gene description for HSPA1L
Gene name heat shock 70kDa protein 1-like
Gene symbol HSPA1L
Other names/aliases HSP70-1L
HSP70-HOM
HSP70T
hum70t
Species Homo sapiens
 Database cross references - HSPA1L
ExoCarta ExoCarta_3305
Vesiclepedia VP_3305
Entrez Gene 3305
HGNC 5234
MIM 140559
UniProt P34931  
 HSPA1L identified in sEVs derived from the following tissue/cell type
Bladder cancer cells 20224111    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Colorectal cancer cells 17956143    
Colorectal cancer cells 19837982    
Embryonic kidney cells 36706192    
Embryonic kidney cells 36706192    
Melanoma cells 22635005    
Melanoma cells 25950383    
Mesenchymal stem cells Unpublished / Not applicable
Mesenchymal stem cells 36408942    
Neuroblastoma cells 25944692    
Prostate cancer cells 22723089    
Prostate cancer cells 22723089    
Prostate cancer cells 22723089    
Urine 21595033    
Urine 21595033    
Urine 21595033    
 Gene ontology annotations for HSPA1L
Molecular Function
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    ATP hydrolysis activity GO:0016887 IBA
    heat shock protein binding GO:0031072 IBA
    heat shock protein binding GO:0031072 IPI
    ubiquitin protein ligase binding GO:0031625 IPI
    protein folding chaperone GO:0044183 IBA
    unfolded protein binding GO:0051082 IDA
    ATP-dependent protein folding chaperone GO:0140662 IEA
Biological Process
    response to unfolded protein GO:0006986 TAS
    binding of sperm to zona pellucida GO:0007339 IEA
    protein refolding GO:0042026 IBA
    protein refolding GO:0042026 IDA
    chaperone cofactor-dependent protein refolding GO:0051085 IBA
    positive regulation of protein targeting to mitochondrion GO:1903955 IMP
Subcellular Localization
    zona pellucida receptor complex GO:0002199 IEA
    nucleus GO:0005634 IBA
    nucleoplasm GO:0005654 TAS
    cytoplasm GO:0005737 IBA
    mitochondrial matrix GO:0005759 IEA
    cytosol GO:0005829 IBA
    cytosol GO:0005829 IDA
    plasma membrane GO:0005886 IBA
    COP9 signalosome GO:0008180 IDA
    cell body GO:0044297 IEA
    blood microparticle GO:0072562 HDA
 Experiment description of studies that identified HSPA1L in sEVs
1
Experiment ID 76
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|GAPDH|HSP90|CD81|CD9|CD63|LAMP1|MHCI
Enriched markers
✔
HSP90B1
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20224111    
Organism Homo sapiens
Experiment description Proteomics analysis of bladder cancer exosomes.
Authors "Welton JL, Khanna S, Giles PJ, Brennan P, Brewis IA, Staffurth J, Mason MD, Clayton A."
Journal name MCP
Publication year 2010
Sample Bladder cancer cells
Sample name HT1376
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.10-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [MALDI TOF/TOF]
Western blotting
FACS
2
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
6
Experiment ID 20
MISEV standards
✔
EM
Biophysical techniques
✔
HSP90|CD63|CD81|LAMP1
Enriched markers
✔
GOLGA2|cytochrome c
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 17956143    
Organism Homo sapiens
Experiment description Proteomic analysis of microvesicles derived from human colorectal cancer cells.
Authors "Choi DS, Lee JM, Park GW, Lim HW, Bang JY, Kim YK, Kwon KH, Kwon HJ, Kim KP, Gho YS"
Journal name JPR
Publication year 2007
Sample Colorectal cancer cells
Sample name HT29
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Diafiltration
Flotation density 1.16 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
7
Experiment ID 21
MISEV standards
✔
EM|IEM
Biophysical techniques
✔
Alix|TSG101|HSP70|CD63
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method
Mass spectrometry   
PubMed ID 19837982    
Organism Homo sapiens
Experiment description Proteomic and bioinformatic analysis of immunoaffinity-purified exosomes derived from the human colon tumor cell line LIM1215.
Authors "Suresh Mathivanan, Justin W.E. Lim, Bow J. Tauro, Hong Ji, Robert L. Moritz and Richard J. Simpson"
Journal name MCP
Publication year 2009
Sample Colorectal cancer cells
Sample name LIM1215
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.10-1.12 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [Orbitrap]
Western blotting
8
Experiment ID 1275
MISEV standards
Biophysical techniques
✔
CD9|TSG101|FLOT1|FLOT2|RAB35|RAB5A|GAPDH|TFRC|CD63|Alix
Enriched markers
✔
PCNA|CANX|GAPDH|HSP90AA1|HSP90B1
Negative markers
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36706192    
Organism Homo sapiens
Experiment description Displaying and delivering viral membrane antigens via WW domain-activated extracellular vesicles
Authors "Choi S, Yang Z, Wang Q, Qiao Z, Sun M, Wiggins J, Xiang SH, Lu Q."
Journal name Sci Adv
Publication year 2023
Sample Embryonic kidney cells
Sample name HEK293T
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
9
Experiment ID 1280
MISEV standards
Biophysical techniques
✔
TSG101|CD9|FLOT1|FLOT2|RAB35|RAB5A|GAPDH|TFRC|CD63|Alix
Enriched markers
✔
PCNA|CANX|GAPDH|HSP90AA1|HSP90B1
Negative markers
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36706192    
Organism Homo sapiens
Experiment description Displaying and delivering viral membrane antigens via WW domain-activated extracellular vesicles
Authors "Choi S, Yang Z, Wang Q, Qiao Z, Sun M, Wiggins J, Xiang SH, Lu Q."
Journal name Sci Adv
Publication year 2023
Sample Embryonic kidney cells
Sample name HEK293T - Fraction 5
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density 1.151 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
10
Experiment ID 200
MISEV standards
✔
EM
Biophysical techniques
✔
HSP70|HSP90|TSG101|Alix|GAPDH
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 22635005    
Organism Homo sapiens
Experiment description Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET.
Authors "Peinado H, Aleckovic M, Lavotshkin S, Matei I, Costa-Silva B, Moreno-Bueno G, Hergueta-Redondo M, Williams C, Garcia-Santos G, Ghajar C, Nitadori-Hoshino A, Hoffman C, Badal K, Garcia BA, Callahan MK, Yuan J, Martins VR, Skog J, Kaplan RN, Brady MS, Wolchok JD, Chapman PB, Kang Y, Bromberg J, Lyden D."
Journal name Nat Med
Publication year 2012
Sample Melanoma cells
Sample name B16-F10
SK-MEL-202
SK-MEL035
SK-MEL-265
Isolation/purification methods Differential centrifugation
Filtration
Sucrose cushion
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
11
Experiment ID 258
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|FLOT1|CD81
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25950383    
Organism Homo sapiens
Experiment description Proteome characterization of melanoma exosomes reveals a specific signature for metastatic cell lines
Authors "Lazar I, Clement E, Ducoux-Petit M, Denat L, Soldan V, Dauvillier S, Balor S4, Burlet-Schiltz O1, Larue L, Muller C Nieto L"
Journal name Pigment Cell Melanoma Res
Publication year 2015
Sample Melanoma cells
Sample name SKMEL28
Isolation/purification methods Differential centrifugation
Unltracentrifugation
Sucrose density gradient
Flotation density 1.13 - 1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
12
Experiment ID 126
MISEV standards
✘ Biophysical techniques
✔
GAPDH
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry [LTQ-FT Ultra]
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors "Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim"
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
13
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
14
Experiment ID 224
MISEV standards
✔
EM|AFM
Biophysical techniques
✔
Alix|TSG101|CD63|CD81
Enriched markers
✔
GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors "Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S"
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
15
Experiment ID 139
MISEV standards
✔
EM
Biophysical techniques
✔
HSP70|HSP90|RAB5|LAMP2|CD9
Enriched markers
✔
HSP90B1
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method
Mass spectrometry [QTOF]   
PubMed ID 22723089    
Organism Homo sapiens
Experiment description Prostate cancer cell derived exosomes
Authors "Hosseini-Beheshti E, Guns ES."
Journal name MCP
Publication year 2012
Sample Prostate cancer cells
Sample name DU145 - Rep 3
Isolation/purification methods Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
16
Experiment ID 143
MISEV standards
✔
EM
Biophysical techniques
✔
HSP70|HSP90|RAB5|LAMP2|CD9
Enriched markers
✔
HSP90B1
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method
Mass spectrometry [QTOF]   
PubMed ID 22723089    
Organism Homo sapiens
Experiment description Prostate cancer cell derived exosomes
Authors "Hosseini-Beheshti E, Guns ES."
Journal name MCP
Publication year 2012
Sample Prostate cancer cells
Sample name LNCaP - Rep 3
Isolation/purification methods Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
17
Experiment ID 145
MISEV standards
✔
EM
Biophysical techniques
✔
HSP70|HSP90|RAB5|CD10
Enriched markers
✔
HSP90B1
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method
Mass spectrometry [QTOF]   
PubMed ID 22723089    
Organism Homo sapiens
Experiment description Prostate cancer cell derived exosomes
Authors "Hosseini-Beheshti E, Guns ES."
Journal name MCP
Publication year 2012
Sample Prostate cancer cells
Sample name C4-2 - Rep 3
Isolation/purification methods Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
18
Experiment ID 193
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|CD9
Enriched markers
✔
PHB
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors "Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC."
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
19
Experiment ID 194
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors "Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC."
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Patients of basement membrane nephropathy
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
20
Experiment ID 195
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors "Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC."
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Patients of early IgA nephropathy
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for HSPA1L
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 EIF4G3 8672
Affinity Capture-MS Homo sapiens
2 PTPRF 5792
Two-hybrid Homo sapiens
3 PRODH  
Affinity Capture-MS Homo sapiens
4 HACD3 51495
Co-fractionation Homo sapiens
5 REC8  
Affinity Capture-MS Homo sapiens
6 SPRTN  
Affinity Capture-MS Homo sapiens
7 UBL4A 8266
Affinity Capture-MS Homo sapiens
8 CDK3 1018
Affinity Capture-MS Homo sapiens
9 SHC1 6464
Affinity Capture-MS Homo sapiens
10 HSPA6 3310
Co-fractionation Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
Co-fractionation Homo sapiens
11 DIS3 22894
Co-fractionation Homo sapiens
12 DCP1B  
Affinity Capture-MS Homo sapiens
13 CCNI2  
Affinity Capture-MS Homo sapiens
14 RIN3  
Affinity Capture-MS Homo sapiens
15 SKI 6497
Affinity Capture-MS Homo sapiens
16 ANKK1  
Affinity Capture-MS Homo sapiens
17 UBE2M 9040
Affinity Capture-MS Homo sapiens
18 KIAA2013 90231
Co-fractionation Homo sapiens
19 BTF3 689
Affinity Capture-MS Homo sapiens
20 CRK 1398
Affinity Capture-MS Homo sapiens
21 DNAJB2 3300
Affinity Capture-MS Homo sapiens
22 EPS15 2060
Affinity Capture-MS Homo sapiens
23 HRAS 3265
Reconstituted Complex Homo sapiens
24 RANBP2 5903
Co-fractionation Homo sapiens
25 HSP90AB1 3326
Co-fractionation Homo sapiens
26 NDUFB7 4713
Co-fractionation Homo sapiens
27 BASP1 10409
Co-fractionation Homo sapiens
28 CAND1 55832
Affinity Capture-MS Homo sapiens
29 ZBTB1  
Affinity Capture-MS Homo sapiens
30 DNAJB14  
Affinity Capture-MS Homo sapiens
31 NDUFS2 4720
Co-fractionation Homo sapiens
32 TRAF2 7186
Co-localization Homo sapiens
33 DNAJB6 10049
Affinity Capture-MS Homo sapiens
34 JAZF1  
Affinity Capture-MS Homo sapiens
35 PPP1CC 5501
Affinity Capture-MS Homo sapiens
36 HSPA4 3308
Affinity Capture-MS Homo sapiens
37 NDUFB9 4715
Co-fractionation Homo sapiens
38 RUVBL1 8607
Affinity Capture-MS Homo sapiens
39 TRMU  
Affinity Capture-MS Homo sapiens
40 DENND2D  
Affinity Capture-MS Homo sapiens
41 TBC1D22A  
Affinity Capture-MS Homo sapiens
42 PCK1 5105
Affinity Capture-MS Homo sapiens
43 ABHD15  
Affinity Capture-MS Homo sapiens
44 COPS6 10980
Affinity Capture-MS Homo sapiens
45 METTL22  
Affinity Capture-MS Homo sapiens
46 COPS5 10987
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
47 KLHL34  
Affinity Capture-MS Homo sapiens
48 HSPH1 10808
Affinity Capture-MS Homo sapiens
49 UBQLN1 29979
Co-fractionation Homo sapiens
50 STIP1 10963
Proximity Label-MS Homo sapiens
51 DYNLL1 8655
Co-fractionation Homo sapiens
52 Dctn4  
Affinity Capture-MS Mus musculus
53 ELP4  
Affinity Capture-MS Homo sapiens
54 DNAJC8 22826
Affinity Capture-MS Homo sapiens
55 DNAJC7 7266
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
56 CEP57  
Affinity Capture-MS Homo sapiens
57 VASH1  
Affinity Capture-MS Homo sapiens
58 ASNS 440
Affinity Capture-MS Homo sapiens
59 MLF2 8079
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
60 CUL1 8454
Affinity Capture-MS Homo sapiens
61 TFCP2 7024
Affinity Capture-MS Homo sapiens
62 ARIH2 10425
Affinity Capture-MS Homo sapiens
63 GPS1 2873
Co-fractionation Homo sapiens
64 HSPA2 3306
Cross-Linking-MS (XL-MS) Homo sapiens
65 FGFR1 2260
Affinity Capture-MS Homo sapiens
66 KCTD13 253980
Affinity Capture-MS Homo sapiens
67 DVL2 1856
Affinity Capture-MS Homo sapiens
68 HSPA8 3312
Cross-Linking-MS (XL-MS) Homo sapiens
69 STOML2 30968
Co-fractionation Homo sapiens
70 CHMP4C 92421
Affinity Capture-MS Homo sapiens
71 PPP1CA 5499
Affinity Capture-MS Homo sapiens
72 CYP2W1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
73 ATP5A1 498
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
74 DNAJB8 165721
Proximity Label-MS Homo sapiens
75 FKBP5 2289
Affinity Capture-MS Homo sapiens
76 DNAJB1 3337
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
77 IPO7 10527
Co-fractionation Homo sapiens
78 USP11 8237
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
79 CUL4B 8450
Affinity Capture-MS Homo sapiens
80 PARK2  
Affinity Capture-MS Homo sapiens
81 CLU 1191
Co-fractionation Homo sapiens
82 CCAR2 57805
Affinity Capture-MS Homo sapiens
83 SHMT1 6470
Co-fractionation Homo sapiens
84 CCDC142  
Affinity Capture-MS Homo sapiens
85 STAU1 6780
Affinity Capture-MS Homo sapiens
86 MCAM 4162
Co-fractionation Homo sapiens
87 CBL 867
Affinity Capture-MS Homo sapiens
88 MRPS36 92259
Co-fractionation Homo sapiens
89 POC1A  
Affinity Capture-MS Homo sapiens
90 DNAJC5 80331
Affinity Capture-MS Homo sapiens
91 UBASH3B 84959
Affinity Capture-MS Homo sapiens
92 YAP1 10413
Affinity Capture-MS Homo sapiens
93 MYH9 4627
Co-fractionation Homo sapiens
94 METTL21C  
Affinity Capture-MS Homo sapiens
95 METTL21A  
Affinity Capture-MS Homo sapiens
96 DCP1A 55802
Affinity Capture-MS Homo sapiens
97 ALDH3B1 221
Affinity Capture-MS Homo sapiens
98 UQCRC1 7384
Co-fractionation Homo sapiens
99 Bag2  
Affinity Capture-MS Mus musculus
100 COPS3 8533
Co-fractionation Homo sapiens
101 FIGNL1 63979
Co-fractionation Homo sapiens
102 PIGS 94005
Co-fractionation Homo sapiens
103 CUL2 8453
Affinity Capture-MS Homo sapiens
104 DNAJC12  
Co-fractionation Homo sapiens
Proximity Label-MS Homo sapiens
105 H2AFX 3014
Affinity Capture-MS Homo sapiens
106 PNMA6A  
Affinity Capture-MS Homo sapiens
107 MCM2 4171
Affinity Capture-MS Homo sapiens
108 DNAJB11 51726
Affinity Capture-MS Homo sapiens
109 ST13 6767
Proximity Label-MS Homo sapiens
110 ID2  
Affinity Capture-MS Homo sapiens
111 NDUFV1 4723
Co-fractionation Homo sapiens
112 TXN2 25828
Co-fractionation Homo sapiens
113 BAG3 9531
Affinity Capture-MS Homo sapiens
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-MS Homo sapiens
114 NUCB2 4925
Co-fractionation Homo sapiens
115 GAN 8139
Affinity Capture-MS Homo sapiens
116 HSPA5 3309
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
117 PSMA3 5684
Affinity Capture-MS Homo sapiens
118 FUK 197258
Affinity Capture-MS Homo sapiens
119 DNAJB4 11080
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
120 ZEB1  
Affinity Capture-MS Homo sapiens
121 CCDC28B  
Affinity Capture-MS Homo sapiens
122 DNAJB12 54788
Affinity Capture-MS Homo sapiens
123 XPO1 7514
Co-fractionation Homo sapiens
124 SLC25A3 5250
Co-fractionation Homo sapiens
125 RELA 5970
Co-localization Homo sapiens
126 HSF1  
Affinity Capture-MS Homo sapiens
127 NCKIPSD 51517
Co-fractionation Homo sapiens
128 CAMK1D 57118
Co-fractionation Homo sapiens
129 RAB11A 8766
Co-fractionation Homo sapiens
130 TRAF3IP1 26146
Affinity Capture-MS Homo sapiens
131 RAP1GDS1 5910
Co-fractionation Homo sapiens
132 TAB1 10454
Co-localization Homo sapiens
133 TRIM38 10475
Two-hybrid Homo sapiens
134 RPL3 6122
Co-fractionation Homo sapiens
135 CUL3 8452
Affinity Capture-MS Homo sapiens
136 CYB5R3 1727
Co-fractionation Homo sapiens
137 UHRF2  
Affinity Capture-MS Homo sapiens
138 FKBP8 23770
Affinity Capture-MS Homo sapiens
139 MAP3K1 4214
Co-localization Homo sapiens
140 METTL21B  
Affinity Capture-MS Homo sapiens
141 NUP214 8021
Co-fractionation Homo sapiens
142 MAP3K7  
Co-localization Homo sapiens
143 SLC25A23  
Affinity Capture-MS Homo sapiens
144 DNAJA1 3301
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
145 ARFIP1 27236
Affinity Capture-MS Homo sapiens
146 GDI2 2665
Affinity Capture-MS Homo sapiens
147 AP2M1 1173
Affinity Capture-MS Homo sapiens
148 CCIN  
Affinity Capture-MS Homo sapiens
149 PTPN7 5778
Affinity Capture-MS Homo sapiens
150 SMAP1 60682
Affinity Capture-MS Homo sapiens
151 LINC00152  
Affinity Capture-RNA Homo sapiens
152 CEP250 11190
Affinity Capture-MS Homo sapiens
153 RETSAT 54884
Affinity Capture-MS Homo sapiens
154 PCBP1 5093
Proximity Label-MS Homo sapiens
155 DCUN1D1 54165
Affinity Capture-MS Homo sapiens
156 DND1  
Affinity Capture-MS Homo sapiens
157 BAG1 573
Affinity Capture-MS Homo sapiens
158 Tpx2  
Affinity Capture-MS Mus musculus
159 EPN3 55040
Affinity Capture-MS Homo sapiens
160 C14orf80  
Affinity Capture-MS Homo sapiens
161 Kifc1  
Affinity Capture-MS Mus musculus
162 HSPA1A 3303
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
Co-fractionation Homo sapiens
163 NFKB1 4790
Co-localization Homo sapiens
164 PRPF40A 55660
Affinity Capture-MS Homo sapiens
165 DNAJC3 5611
Affinity Capture-MS Homo sapiens
166 DHFRL1  
Proximity Label-MS Homo sapiens
167 ILK 3611
Affinity Capture-MS Homo sapiens
168 CLTC 1213
Proximity Label-MS Homo sapiens
169 DLAT 1737
Co-fractionation Homo sapiens
170 SIRT3  
Affinity Capture-MS Homo sapiens
171 BAG4  
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
172 TTLL3 26140
Affinity Capture-MS Homo sapiens
173 STUB1 10273
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
174 CLPP 8192
Proximity Label-MS Homo sapiens
175 SNCA 6622
Affinity Capture-MS Homo sapiens
176 SNW1 22938
Affinity Capture-MS Homo sapiens
177 ARRB2 409
Affinity Capture-MS Homo sapiens
178 CDC20 991
Affinity Capture-MS Homo sapiens
179 SIRT6  
Affinity Capture-MS Homo sapiens
180 RRBP1 6238
Co-fractionation Homo sapiens
181 GRB2 2885
Affinity Capture-MS Homo sapiens
182 DNAJC19 131118
Co-fractionation Homo sapiens
183 TOMM34 10953
Proximity Label-MS Homo sapiens
184 TP53 7157
Affinity Capture-MS Homo sapiens
Co-localization Homo sapiens
185 TOMM22 56993
Co-fractionation Homo sapiens
186 URGCP 55665
Affinity Capture-MS Homo sapiens
187 TUBG1 7283
Affinity Capture-MS Homo sapiens
188 INPPL1 3636
Affinity Capture-MS Homo sapiens
189 TNFAIP1 7126
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
190 DNAJA2 10294
Affinity Capture-MS Homo sapiens
191 MCM5 4174
Affinity Capture-MS Homo sapiens
192 LRRC28  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
193 OPALIN  
Affinity Capture-MS Homo sapiens
194 CUL5 8065
Affinity Capture-MS Homo sapiens
195 CCDC117  
Affinity Capture-MS Homo sapiens
196 MAPRE2 10982
Affinity Capture-MS Homo sapiens
197 MRPL1  
Co-fractionation Homo sapiens
198 DNAJB5  
Affinity Capture-MS Homo sapiens
199 RUVBL2 10856
Affinity Capture-MS Homo sapiens
200 HAUS5 23354
Affinity Capture-MS Homo sapiens
201 HSP90AA1 3320
Affinity Capture-MS Homo sapiens
202 EPB41L2 2037
Co-fractionation Homo sapiens
203 SIRT1  
Affinity Capture-MS Homo sapiens
204 TRIM25 7706
Affinity Capture-MS Homo sapiens
205 ESR1  
Affinity Capture-MS Homo sapiens
206 COPS8 10920
Co-fractionation Homo sapiens
207 HSPBP1 23640
Affinity Capture-MS Homo sapiens
208 GAPDH 2597
Co-fractionation Homo sapiens
209 DNAJC13 23317
Proximity Label-MS Homo sapiens
210 DNAJC5B  
Affinity Capture-MS Homo sapiens
211 NEDD1 121441
Affinity Capture-MS Homo sapiens
212 AIRE  
Affinity Capture-MS Homo sapiens
213 PINK1  
Affinity Capture-MS Homo sapiens
214 CLTA 1211
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
215 DPF3  
Affinity Capture-MS Homo sapiens
216 NEDD8 4738
Affinity Capture-MS Homo sapiens
217 BAG5 9529
Affinity Capture-MS Homo sapiens
218 DOCK7 85440
Co-fractionation Homo sapiens
219 ZUFSP 221302
Affinity Capture-MS Homo sapiens
220 PIK3R2 5296
Affinity Capture-MS Homo sapiens
221 CUL7 9820
Affinity Capture-MS Homo sapiens
222 DNAJA3 9093
Affinity Capture-MS Homo sapiens
223 EDRF1  
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
224 ATXN3 4287
Affinity Capture-MS Homo sapiens
225 SOHLH1  
Affinity Capture-MS Homo sapiens
226 CUL4A 8451
Affinity Capture-MS Homo sapiens
227 CDC5L 988
Co-fractionation Homo sapiens
228 HNRNPA2B1 3181
Affinity Capture-MS Homo sapiens
229 LPGAT1 9926
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here