Gene description for LPGAT1
Gene name lysophosphatidylglycerol acyltransferase 1
Gene symbol LPGAT1
Other names/aliases FAM34A
FAM34A1
NET8
Species Homo sapiens
 Database cross references - LPGAT1
ExoCarta ExoCarta_9926
Entrez Gene 9926
HGNC 28985
MIM 610473
UniProt Q92604  
 LPGAT1 identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells 25944692    
 Gene ontology annotations for LPGAT1
Molecular Function
    molecular_function GO:0003674 ND
    transferase activity, transferring acyl groups GO:0016746 IEA
Biological Process
    glycerophospholipid biosynthetic process GO:0046474 TAS
    phosphatidylglycerol acyl-chain remodeling GO:0036148 TAS
    small molecule metabolic process GO:0044281 TAS
    phospholipid metabolic process GO:0006644 TAS
    biological_process GO:0008150 ND
Subcellular Localization
    endoplasmic reticulum membrane GO:0005789 TAS
    cytoplasm GO:0005737 IDA
    integral component of membrane GO:0016021 IEA
    membrane GO:0016020 IDA
 Experiment description of studies that identified LPGAT1 in exosomes
1
Experiment ID 224
ISEV standards
EM|AFM
EV Biophysical techniques
Alix|TSG101
EV Cytosolic markers
CD63|CD81
EV Membrane markers
GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for LPGAT1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which LPGAT1 is involved
PathwayEvidenceSource
Acyl chain remodelling of PG TAS Reactome





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