Gene description for ISG20L2
Gene name interferon stimulated exonuclease gene 20kDa-like 2
Gene symbol ISG20L2
Other names/aliases HSD38
Species Homo sapiens
 Database cross references - ISG20L2
ExoCarta ExoCarta_81875
Entrez Gene 81875
HGNC 25745
MIM 611930
UniProt Q9H9L3  
 ISG20L2 identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells 25944692    
 Gene ontology annotations for ISG20L2
Molecular Function
    protein binding GO:0005515 IPI
    exonuclease activity GO:0004527 IEA
    poly(A) RNA binding GO:0044822 IDA
Biological Process
    ribosome biogenesis GO:0042254 IEA
    nucleic acid phosphodiester bond hydrolysis GO:0090305 IEA
Subcellular Localization
    nucleoplasm GO:0005654 IDA
    nucleolus GO:0005730 IEA
 Experiment description of studies that identified ISG20L2 in exosomes
1
Experiment ID 224
ISEV standards
EM|AFM
EV Biophysical techniques
Alix|TSG101
EV Cytosolic markers
CD63|CD81
EV Membrane markers
GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for ISG20L2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 EML1  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which ISG20L2 is involved
No pathways found





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