Gene description for ISG20L2
Gene name interferon stimulated exonuclease gene 20kDa-like 2
Gene symbol ISG20L2
Other names/aliases HSD38
Species Homo sapiens
 Database cross references - ISG20L2
ExoCarta ExoCarta_81875
Vesiclepedia VP_81875
Entrez Gene 81875
HGNC 25745
MIM 611930
UniProt Q9H9L3  
 ISG20L2 identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells 25944692    
 Gene ontology annotations for ISG20L2
Molecular Function
    3'-5'-RNA exonuclease activity GO:0000175 IEA
    RNA binding GO:0003723 HDA
    exonuclease activity GO:0004527 IBA
    protein binding GO:0005515 IPI
Biological Process
    RNA processing GO:0006396 IBA
    ribosome biogenesis GO:0042254 IEA
Subcellular Localization
    nucleus GO:0005634 IBA
    nucleolus GO:0005730 IEA
 Experiment description of studies that identified ISG20L2 in exosomes
1
Experiment ID 224
MISEV standards
✔
EM|AFM
Biophysical techniques
✔
Alix|TSG101|CD63|CD81
Enriched markers
✔
GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for ISG20L2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 EML1 2009
Two-hybrid Homo sapiens
2 CD3EAP  
Proximity Label-MS Homo sapiens
3 HECTD1 25831
Affinity Capture-MS Homo sapiens
4 SUCO  
Affinity Capture-MS Homo sapiens
5 SURF6  
Affinity Capture-MS Homo sapiens
6 MYCN  
Affinity Capture-MS Homo sapiens
7 RPL19 6143
Affinity Capture-MS Homo sapiens
8 RIT1 6016
Negative Genetic Homo sapiens
9 MNDA 4332
Affinity Capture-MS Homo sapiens
10 TRIP13 9319
Cross-Linking-MS (XL-MS) Homo sapiens
11 ANAPC15  
Affinity Capture-MS Homo sapiens
12 CDK16 5127
Affinity Capture-MS Homo sapiens
13 SPTA1  
Cross-Linking-MS (XL-MS) Homo sapiens
14 HIST1H4A 8359
Affinity Capture-MS Homo sapiens
15 RPL3 6122
Affinity Capture-MS Homo sapiens
16 HSPB1 3315
Two-hybrid Homo sapiens
17 GNL2 29889
Affinity Capture-MS Homo sapiens
18 ZBTB47  
Affinity Capture-MS Homo sapiens
19 MYC  
Affinity Capture-MS Homo sapiens
20 PDCD11 22984
Affinity Capture-MS Homo sapiens
21 MKI67  
Affinity Capture-MS Homo sapiens
22 CENPA  
Proximity Label-MS Homo sapiens
23 USP36  
Affinity Capture-MS Homo sapiens
24 C6orf118  
Cross-Linking-MS (XL-MS) Homo sapiens
25 RPS24 6229
Proximity Label-MS Homo sapiens
26 TMEM75  
Affinity Capture-MS Homo sapiens
27 RPL31 6160
Proximity Label-MS Homo sapiens
28 IFI16 3428
Affinity Capture-MS Homo sapiens
29 HIST1H1E 3008
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 RPS6 6194
Proximity Label-MS Homo sapiens
31 GRSF1 2926
Proximity Label-MS Homo sapiens
32 Setd2  
Affinity Capture-MS Mus musculus
33 PPAN 56342
Affinity Capture-MS Homo sapiens
34 KRAS 3845
Negative Genetic Homo sapiens
35 Setd3  
Affinity Capture-MS Mus musculus
36 GNB2L1 10399
Affinity Capture-MS Homo sapiens
37 NPM1 4869
Affinity Capture-MS Homo sapiens
38 PSPC1 55269
Affinity Capture-MS Homo sapiens
39 ANOS1 3730
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here