Gene description for LARP4
Gene name La ribonucleoprotein domain family, member 4
Gene symbol LARP4
Other names/aliases PP13296
Species Homo sapiens
 Database cross references - LARP4
ExoCarta ExoCarta_113251
Vesiclepedia VP_113251
Entrez Gene 113251
HGNC 24320
UniProt Q71RC2  
 LARP4 identified in exosomes derived from the following tissue/cell type
Chondrocytes 35931686    
Chondrocytes 35931686    
 Gene ontology annotations for LARP4
Molecular Function
    RNA binding GO:0003723 HDA
    mRNA 3'-UTR binding GO:0003730 IBA
    mRNA 3'-UTR binding GO:0003730 IDA
    protein binding GO:0005515 IPI
    poly(A) binding GO:0008143 IDA
Biological Process
    translation GO:0006412 IEA
    cytoskeleton organization GO:0007010 IMP
    post-transcriptional regulation of gene expression GO:0010608 IDA
    regulation of cell morphogenesis GO:0022604 IMP
    positive regulation of translation GO:0045727 IBA
    positive regulation of translation GO:0045727 IMP
Subcellular Localization
    cytosol GO:0005829 IBA
    cytosol GO:0005829 IDA
    cytoplasmic stress granule GO:0010494 IDA
    membrane GO:0016020 HDA
    cytosolic small ribosomal subunit GO:0022627 IDA
 Experiment description of studies that identified LARP4 in exosomes
1
Experiment ID 497
MISEV standards
Biophysical techniques
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|RAB5A|SDCBP|TFRC|TSG101|UCHL1
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 498
MISEV standards
EM
Biophysical techniques
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|RAB5A|SDCBP|TFRC|TSG101|UCHL1
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for LARP4
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HNRNPH1 3187
Affinity Capture-RNA Homo sapiens
2 CCL3  
Affinity Capture-MS Homo sapiens
3 RPSA 3921
Co-fractionation Homo sapiens
4 EXOSC7 23016
Two-hybrid Homo sapiens
5 ZC3H7A  
Two-hybrid Homo sapiens
6 MTCH1 23787
Proximity Label-MS Homo sapiens
7 APOBEC3D  
Affinity Capture-MS Homo sapiens
8 ZNF346  
Affinity Capture-MS Homo sapiens
9 PDAP1 11333
Cross-Linking-MS (XL-MS) Homo sapiens
10 TARDBP 23435
Affinity Capture-MS Homo sapiens
11 COPS6 10980
Affinity Capture-MS Homo sapiens
12 RPS19 6223
Co-fractionation Homo sapiens
13 RPL10 6134
Affinity Capture-MS Homo sapiens
14 BPNT1 10380
Affinity Capture-MS Homo sapiens
15 PTPN1 5770
Proximity Label-MS Homo sapiens
16 APP 351
Reconstituted Complex Homo sapiens
17 LSM5 23658
Two-hybrid Homo sapiens
18 RPS3 6188
Co-fractionation Homo sapiens
19 APEX1 328
Affinity Capture-RNA Homo sapiens
20 RPS20 6224
Proximity Label-MS Homo sapiens
21 GSPT2 23708
Affinity Capture-MS Homo sapiens
22 B3GNT2 10678
Affinity Capture-MS Homo sapiens
23 KIF23 9493
Affinity Capture-MS Homo sapiens
24 SPRTN  
Affinity Capture-MS Homo sapiens
25 LENG1  
Two-hybrid Homo sapiens
26 PRC1 9055
Two-hybrid Homo sapiens
27 NPM1 4869
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 Hnrnpk 15387
Two-hybrid Mus musculus
29 FBL 2091
Proximity Label-MS Homo sapiens
30 RPS12 6206
Co-fractionation Homo sapiens
31 OBSL1 23363
Affinity Capture-MS Homo sapiens
32 EXD2  
Proximity Label-MS Homo sapiens
33 Kif2a 16563
Affinity Capture-MS Mus musculus
34 FBXW8 26259
Affinity Capture-MS Homo sapiens
35 CALR 811
Co-fractionation Homo sapiens
36 Eif3a 13669
Affinity Capture-MS Mus musculus
37 RNF126  
Affinity Capture-MS Homo sapiens
38 MYCN  
Affinity Capture-MS Homo sapiens
39 RBM42  
Affinity Capture-MS Homo sapiens
40 MARCH5  
Proximity Label-MS Homo sapiens
41 RBM8A 9939
Affinity Capture-MS Homo sapiens
42 KIF14 9928
Affinity Capture-MS Homo sapiens
43 LARP4B 23185
Affinity Capture-MS Homo sapiens
44 LIN28A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
45 CPEB1  
Proximity Label-MS Homo sapiens
46 PRPF6 24148
Two-hybrid Homo sapiens
47 SRP9 6726
Affinity Capture-MS Homo sapiens
48 WBP4  
Two-hybrid Homo sapiens
49 MTCH2 23788
Proximity Label-MS Homo sapiens
50 RNF4 6047
Affinity Capture-MS Homo sapiens
51 LIN28B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
52 RPS10 6204
Co-fractionation Homo sapiens
53 HIST1H2AG 8969
Cross-Linking-MS (XL-MS) Homo sapiens
54 SRSF3 6428
Affinity Capture-MS Homo sapiens
55 YBX2 51087
Affinity Capture-MS Homo sapiens
56 MAPRE1 22919
Affinity Capture-MS Homo sapiens
57 RPL5 6125
Affinity Capture-MS Homo sapiens
58 Pabpc1 18458
Affinity Capture-MS Mus musculus
59 AKAP1 8165
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
60 POU6F2  
Two-hybrid Homo sapiens
61 PFDN2 5202
Affinity Capture-MS Homo sapiens
62 Srp72  
Affinity Capture-MS Mus musculus
63 NTRK1 4914
Affinity Capture-MS Homo sapiens
64 IFI16 3428
Affinity Capture-MS Homo sapiens
65 TGM5  
Two-hybrid Homo sapiens
66 HECTD1 25831
Affinity Capture-MS Homo sapiens
67 Fubp3  
Two-hybrid Mus musculus
68 TXNL4A 10907
Two-hybrid Homo sapiens
69 RHOT2 89941
Proximity Label-MS Homo sapiens
70 RMDN3 55177
Proximity Label-MS Homo sapiens
71 MAT2A 4144
Cross-Linking-MS (XL-MS) Homo sapiens
72 FNDC3B 64778
Two-hybrid Homo sapiens
73 S100P 6286
Affinity Capture-MS Homo sapiens
74 Rbm38  
Two-hybrid Mus musculus
75 RPS2 6187
Co-fractionation Homo sapiens
76 RC3H2  
Affinity Capture-MS Homo sapiens
77 RBM47 54502
Affinity Capture-MS Homo sapiens
78 SIRT7  
Affinity Capture-MS Homo sapiens
79 SRSF1 6426
Affinity Capture-MS Homo sapiens
80 CUL3 8452
Affinity Capture-MS Homo sapiens
81 BHLHE40  
Two-hybrid Homo sapiens
82 EGFR 1956
Affinity Capture-MS Homo sapiens
83 FKBP8 23770
Proximity Label-MS Homo sapiens
84 MYC  
Affinity Capture-MS Homo sapiens
85 MYO1C 4641
Affinity Capture-MS Homo sapiens
86 OCIAD1 54940
Proximity Label-MS Homo sapiens
87 CRX  
Two-hybrid Homo sapiens
88 RPS27 6232
Co-fractionation Homo sapiens
89 PRR3  
Affinity Capture-MS Homo sapiens
90 PSPC1 55269
Affinity Capture-MS Homo sapiens
91 EIF2D 1939
Co-fractionation Homo sapiens
92 PABPC5 140886
Affinity Capture-MS Homo sapiens
93 KAT5  
Two-hybrid Homo sapiens
94 BCAS2 10286
Two-hybrid Homo sapiens
95 MFN2 9927
Proximity Label-MS Homo sapiens
96 DDRGK1 65992
Affinity Capture-MS Homo sapiens
97 PCM1 5108
Two-hybrid Homo sapiens
98 PFDN5 5204
Two-hybrid Homo sapiens
99 RBMS2 5939
Affinity Capture-MS Homo sapiens
100 RPS16 6217
Affinity Capture-MS Homo sapiens
101 PAIP1 10605
Affinity Capture-MS Homo sapiens
102 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
103 SIRT6  
Affinity Capture-MS Homo sapiens
104 ILF3 3609
Affinity Capture-RNA Homo sapiens
105 OMP  
Affinity Capture-MS Homo sapiens
106 FBXO10  
Affinity Capture-MS Homo sapiens
107 MNDA 4332
Affinity Capture-MS Homo sapiens
108 DDX3X 1654
Co-fractionation Homo sapiens
109 Ccdc77  
Affinity Capture-MS Mus musculus
110 SRP19 6728
Affinity Capture-MS Homo sapiens
111 PFDN1 5201
Affinity Capture-MS Homo sapiens
112 PAX5  
Two-hybrid Homo sapiens
113 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
114 G3BP2 9908
Affinity Capture-MS Homo sapiens
115 NUP35 129401
Proximity Label-MS Homo sapiens
116 PRKACA 5566
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
117 YTHDF3  
Two-hybrid Homo sapiens
118 PRPF39 55015
Two-hybrid Homo sapiens
119 TRIM31  
Affinity Capture-MS Homo sapiens
120 TPST2 8459
Affinity Capture-MS Homo sapiens
121 SERBP1 26135
Proximity Label-MS Homo sapiens
122 GNB2L1 10399
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
123 RC3H1 149041
Affinity Capture-MS Homo sapiens
124 PRMT1 3276
Affinity Capture-MS Homo sapiens
125 ZNF830  
Two-hybrid Homo sapiens
126 EP300 2033
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which LARP4 is involved
No pathways found





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