Gene description for TXNL4A
Gene name thioredoxin-like 4A
Gene symbol TXNL4A
Other names/aliases BMKS
DIB1
DIM1
SNRNP15
TXNL4
U5-15kD
Species Homo sapiens
 Database cross references - TXNL4A
ExoCarta ExoCarta_10907
Entrez Gene 10907
HGNC 30551
MIM 611595
UniProt P83876  
 TXNL4A identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
Hepatocytes 26054723    
 Gene ontology annotations for TXNL4A
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    cell division GO:0051301 IEA
    mitotic nuclear division GO:0007067 IEA
    gene expression GO:0010467 TAS
    mRNA splicing, via spliceosome GO:0000398 TAS
    RNA splicing, via transesterification reactions GO:0000375 TAS
    spliceosomal complex assembly GO:0000245 TAS
    RNA splicing GO:0008380 TAS
Subcellular Localization
    U4/U6 x U5 tri-snRNP complex GO:0046540 IBA
    nucleoplasm GO:0005654 TAS
    spliceosomal complex GO:0005681 TAS
    U5 snRNP GO:0005682 IBA
 Experiment description of studies that identified TXNL4A in exosomes
1
Experiment ID 236
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
✘ EV Membrane markers
✔
HSP90B1
EV Negative markers
✔
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name MHCC97L
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
2
Experiment ID 237
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
✘ EV Membrane markers
✔
HSP90B1
EV Negative markers
✔
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for TXNL4A
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PQBP1  
Invivo Homo sapiens
Two-hybrid Homo sapiens
2 RHEBL1  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which TXNL4A is involved
PathwayEvidenceSource
mRNA Splicing - Major Pathway TAS Reactome
mRNA Splicing - Minor Pathway TAS Reactome





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