Gene description for TXNL4A
Gene name thioredoxin-like 4A
Gene symbol TXNL4A
Other names/aliases BMKS
DIB1
DIM1
SNRNP15
TXNL4
U5-15kD
Species Homo sapiens
 Database cross references - TXNL4A
ExoCarta ExoCarta_10907
Vesiclepedia VP_10907
Entrez Gene 10907
HGNC 30551
MIM 611595
UniProt P83876  
 TXNL4A identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
Hepatocytes 26054723    
 Gene ontology annotations for TXNL4A
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    spliceosomal complex assembly GO:0000245 TAS
    RNA splicing, via transesterification reactions GO:0000375 TAS
    mRNA splicing, via spliceosome GO:0000398 IDA
    mRNA splicing, via spliceosome GO:0000398 NAS
    cell division GO:0051301 IEA
Subcellular Localization
    nucleus GO:0005634 IDA
    nucleus GO:0005634 NAS
    nucleoplasm GO:0005654 IDA
    nucleoplasm GO:0005654 TAS
    spliceosomal complex GO:0005681 IBA
    spliceosomal complex GO:0005681 TAS
    U5 snRNP GO:0005682 IBA
    cytosol GO:0005829 IDA
    U4/U6 x U5 tri-snRNP complex GO:0046540 IBA
    U4/U6 x U5 tri-snRNP complex GO:0046540 IDA
    U4/U6 x U5 tri-snRNP complex GO:0046540 IPI
    U2-type precatalytic spliceosome GO:0071005 IDA
 Experiment description of studies that identified TXNL4A in exosomes
1
Experiment ID 236
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
Enriched markers
✔
HSP90B1
Negative markers
✔
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name MHCC97L
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
2
Experiment ID 237
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
Enriched markers
✔
HSP90B1
Negative markers
✔
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for TXNL4A
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CHMP2A 27243
Affinity Capture-MS Homo sapiens
2 ATG16L1 55054
Affinity Capture-MS Homo sapiens
3 GSTP1 2950
Affinity Capture-MS Homo sapiens
4 SNRPA 6626
Affinity Capture-MS Homo sapiens
5 ALG13 79868
Two-hybrid Homo sapiens
6 SNW1 22938
Two-hybrid Homo sapiens
7 PQBP1  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
8 RBM42  
Affinity Capture-MS Homo sapiens
9 RBM39 9584
Affinity Capture-MS Homo sapiens
10 SNRPG 6637
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 SF3B1 23451
Affinity Capture-MS Homo sapiens
12 RBM22 55696
Two-hybrid Homo sapiens
13 PRPF4B 8899
Affinity Capture-MS Homo sapiens
14 USP43  
Affinity Capture-MS Homo sapiens
15 EXOC5 10640
Two-hybrid Homo sapiens
16 TOP1 7150
Affinity Capture-MS Homo sapiens
17 CPSF6 11052
Affinity Capture-MS Homo sapiens
18 KIF14 9928
Affinity Capture-MS Homo sapiens
19 Bbs5  
Two-hybrid Mus musculus
20 Iffo1  
Affinity Capture-MS Mus musculus
21 DMRTB1  
Two-hybrid Homo sapiens
22 KIFC3 3801
Affinity Capture-MS Homo sapiens
23 Cstf2t  
Two-hybrid Mus musculus
24 UNK  
Affinity Capture-RNA Homo sapiens
25 SSRP1 6749
Affinity Capture-MS Homo sapiens
26 CD2BP2 10421
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
27 PRPF6 24148
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
28 WDFY1 57590
Co-fractionation Homo sapiens
29 ID1  
Affinity Capture-MS Homo sapiens
30 USP39 10713
Affinity Capture-MS Homo sapiens
31 Rmdn3  
Affinity Capture-MS Mus musculus
32 Rbm14  
Two-hybrid Mus musculus
33 CBR1 873
Affinity Capture-MS Homo sapiens
34 RBPMS 11030
Two-hybrid Homo sapiens
35 PRPF3  
Affinity Capture-MS Homo sapiens
36 TPD52L1 7164
Affinity Capture-MS Homo sapiens
37 RET 5979
Affinity Capture-MS Homo sapiens
38 Mrps31  
Two-hybrid Mus musculus
39 TSSC4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
40 DDIT4L  
Two-hybrid Homo sapiens
41 DDX23 9416
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
42 PRRC2B  
Two-hybrid Homo sapiens
43 SNRPD2 6633
Affinity Capture-MS Homo sapiens
44 Nudt21 68219
Two-hybrid Mus musculus
45 PDE6D 5147
Affinity Capture-MS Homo sapiens
46 SF3A1 10291
Affinity Capture-MS Homo sapiens
47 Spred2  
Affinity Capture-MS Mus musculus
48 LZTS2 84445
Two-hybrid Homo sapiens
49 SNRNP200 23020
Affinity Capture-MS Homo sapiens
50 SNRNP40 9410
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
51 SNRPB 6628
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
52 Eif3g 53356
Two-hybrid Mus musculus
53 ANKHD1 54882
Two-hybrid Homo sapiens
54 TNRC6A 27327
Two-hybrid Homo sapiens
55 SNRPN 6638
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
56 Rhoa 11848
Affinity Capture-MS Mus musculus
57 TSNAX 7257
Affinity Capture-MS Homo sapiens
58 PRPF8 10594
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
59 SYNCRIP 10492
Affinity Capture-MS Homo sapiens
60 HNRNPF 3185
Two-hybrid Homo sapiens
61 RHEBL1  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
62 SNRPE 6635
Affinity Capture-MS Homo sapiens
63 PRPF4 9128
Affinity Capture-MS Homo sapiens
64 CPSF7 79869
Two-hybrid Homo sapiens
65 KRAS 3845
Affinity Capture-MS Homo sapiens
66 SNRPC 6631
Affinity Capture-MS Homo sapiens
67 Pef1  
Two-hybrid Mus musculus
68 QKI 9444
Two-hybrid Homo sapiens
69 Hnrnpf 98758
Two-hybrid Mus musculus
70 SNRPF 6636
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
71 NANOG  
Affinity Capture-MS Homo sapiens
72 EFTUD2 9343
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
73 PRC1 9055
Affinity Capture-MS Homo sapiens
74 KRT31 3881
Two-hybrid Homo sapiens
75 GRIA2  
Affinity Capture-MS Homo sapiens
76 Ssbp1  
Two-hybrid Mus musculus
77 LARP4 113251
Two-hybrid Homo sapiens
78 Hnrnph2 56258
Two-hybrid Mus musculus
79 EP300 2033
Affinity Capture-MS Homo sapiens
80 SNRPD3 6634
Affinity Capture-MS Homo sapiens
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