Gene description for TNRC6A
Gene name trinucleotide repeat containing 6A
Gene symbol TNRC6A
Other names/aliases CAGH26
GW1
GW182
TNRC6
Species Homo sapiens
 Database cross references - TNRC6A
ExoCarta ExoCarta_27327
Entrez Gene 27327
HGNC 11969
MIM 610739
UniProt Q8NDV7  
 TNRC6A identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for TNRC6A
Molecular Function
    nucleotide binding GO:0000166 IEA
    protein binding GO:0005515 IPI
    poly(A) RNA binding GO:0044822 IDA
Biological Process
    Notch signaling pathway GO:0007219 TAS
    neurotrophin TRK receptor signaling pathway GO:0048011 TAS
    fibroblast growth factor receptor signaling pathway GO:0008543 TAS
    phosphatidylinositol-mediated signaling GO:0048015 TAS
    Fc-epsilon receptor signaling pathway GO:0038095 TAS
    epidermal growth factor receptor signaling pathway GO:0007173 TAS
    cellular response to starvation GO:0009267 IEA
    posttranscriptional gene silencing GO:0016441 TAS
    negative regulation of translation involved in gene silencing by miRNA GO:0035278 IDA
    innate immune response GO:0045087 TAS
    gene expression GO:0010467 TAS
    gene silencing by miRNA GO:0035195 IMP
Subcellular Localization
    cytoplasmic mRNA processing body GO:0000932 IDA
    micro-ribonucleoprotein complex GO:0035068 IDA
    cytosol GO:0005829 TAS
    nucleoplasm GO:0005654 TAS
 Experiment description of studies that identified TNRC6A in exosomes
1
Experiment ID 237
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for TNRC6A
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 N/A  
Reconstituted Complex 3702
2 AGO2 27161
Reconstituted Complex Homo sapiens
View the network image/svg+xml



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