Gene description for TNRC6A
Gene name trinucleotide repeat containing 6A
Gene symbol TNRC6A
Other names/aliases CAGH26
GW1
GW182
TNRC6
Species Homo sapiens
 Database cross references - TNRC6A
ExoCarta ExoCarta_27327
Vesiclepedia VP_27327
Entrez Gene 27327
HGNC 11969
MIM 610739
UniProt Q8NDV7  
 TNRC6A identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for TNRC6A
Molecular Function
    RNA binding GO:0003723 HDA
    protein binding GO:0005515 IPI
    protein-macromolecule adaptor activity GO:0030674 HDA
Biological Process
    endoderm development GO:0007492 IEA
    cellular response to starvation GO:0009267 IEA
    P-body assembly GO:0033962 IDA
    miRNA-mediated post-transcriptional gene silencing GO:0035195 IBA
    miRNA-mediated post-transcriptional gene silencing GO:0035195 IMP
    miRNA-mediated gene silencing by inhibition of translation GO:0035278 IDA
    positive regulation of nuclear-transcribed mRNA poly(A) tail shortening GO:0060213 IBA
Subcellular Localization
    P-body GO:0000932 IBA
    P-body GO:0000932 IDA
    P-body GO:0000932 IDA
    nucleoplasm GO:0005654 IBA
    nucleoplasm GO:0005654 IDA
    nucleoplasm GO:0005654 TAS
    Golgi apparatus GO:0005794 IDA
    cytosol GO:0005829 TAS
    RISC complex GO:0016442 IDA
    intracellular membrane-bounded organelle GO:0043231 IDA
 Experiment description of studies that identified TNRC6A in exosomes
1
Experiment ID 237
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for TNRC6A
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CNOT7 29883
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
2 MIB1 57534
Proximity Label-MS Homo sapiens
3 ISX  
Proximity Label-MS Homo sapiens
4 AP2B1 163
Proximity Label-MS Homo sapiens
5 WNK1 65125
Two-hybrid Homo sapiens
6 KIAA2013 90231
Affinity Capture-MS Homo sapiens
7 TRIM66  
Affinity Capture-MS Homo sapiens
8 QKI 9444
Two-hybrid Homo sapiens
9 GFAP 2670
Proximity Label-MS Homo sapiens
10 PRPH 5630
Proximity Label-MS Homo sapiens
11 KIF20A 10112
Affinity Capture-MS Homo sapiens
12 UBC 7316
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
13 EYA2  
Proximity Label-MS Homo sapiens
14 CLTB 1212
Affinity Capture-MS Homo sapiens
15 STX4 6810
Proximity Label-MS Homo sapiens
16 SOX2  
Affinity Capture-MS Homo sapiens
17 PDE2A  
Affinity Capture-MS Homo sapiens
18 RPS20 6224
Proximity Label-MS Homo sapiens
19 CNOT10 25904
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
20 IMPDH2 3615
Proximity Label-MS Homo sapiens
21 ACTR3 10096
Proximity Label-MS Homo sapiens
22 CNOT3 4849
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
23 AGO3  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 Ssbp1  
Two-hybrid Mus musculus
25 GTSE1 51512
Affinity Capture-MS Homo sapiens
26 ARIH2 10425
Affinity Capture-MS Homo sapiens
27 AMOT  
Proximity Label-MS Homo sapiens
28 KIF14 9928
Affinity Capture-MS Homo sapiens
29 DMRTB1  
Two-hybrid Homo sapiens
30 NINL  
Proximity Label-MS Homo sapiens
31 CPEB1  
Proximity Label-MS Homo sapiens
32 KRT8 3856
Proximity Label-MS Homo sapiens
33 Ubr5  
Co-crystal Structure Rattus norvegicus
34 AGO2 27161
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
35 CNOT2  
Affinity Capture-Western Homo sapiens
36 EMD 2010
Proximity Label-MS Homo sapiens
37 RB1CC1 9821
Affinity Capture-MS Homo sapiens
38 FANCM 57697
Affinity Capture-MS Homo sapiens
39 PAN2  
Reconstituted Complex Homo sapiens
40 UBR5 51366
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
41 PABPC1 26986
Co-crystal Structure Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
42 CNOT1 23019
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
43 TRIM21 6737
Affinity Capture-MS Homo sapiens
44 GLI3 2737
Proximity Label-MS Homo sapiens
45 DTX2 113878
Proximity Label-MS Homo sapiens
46 CNOT6L 246175
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
47 BICD2 23299
Proximity Label-MS Homo sapiens
48 STIL  
Proximity Label-MS Homo sapiens
49 TXNL4A 10907
Two-hybrid Homo sapiens
50 PICALM 8301
Affinity Capture-MS Homo sapiens
51 C17orf53  
Proximity Label-MS Homo sapiens
52 TRIP13 9319
Two-hybrid Homo sapiens
53 CNOT6  
Affinity Capture-Western Homo sapiens
54 CEP135  
Proximity Label-MS Homo sapiens
55 PAN3 255967
Affinity Capture-Western Homo sapiens
56 RLIM 51132
Affinity Capture-MS Homo sapiens
57 RQCD1 9125
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
58 PHIP 55023
Affinity Capture-MS Homo sapiens
59 CUL3 8452
Affinity Capture-MS Homo sapiens
60 SASS6 163786
Proximity Label-MS Homo sapiens
61 CEP250 11190
Affinity Capture-MS Homo sapiens
62 AGO4  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
63 RPA3 6119
Proximity Label-MS Homo sapiens
64 NIN 51199
Proximity Label-MS Homo sapiens
65 SAV1  
Proximity Label-MS Homo sapiens
66 ITGB4 3691
Affinity Capture-MS Homo sapiens
67 BICD1 636
Proximity Label-MS Homo sapiens
68 CLTC 1213
Affinity Capture-MS Homo sapiens
69 NUP35 129401
Proximity Label-MS Homo sapiens
70 KRT19 3880
Proximity Label-MS Homo sapiens
71 AKAP1 8165
Proximity Label-MS Homo sapiens
72 AK4 205
Affinity Capture-MS Homo sapiens
73 KRT18 3875
Proximity Label-MS Homo sapiens
74 RNF43  
Proximity Label-MS Homo sapiens
75 FBXL6  
Proximity Label-MS Homo sapiens
76 AGO1  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
77 TRIM65 201292
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
78 SQSTM1 8878
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
79 FKBP9 11328
Affinity Capture-MS Homo sapiens
80 NUP155 9631
Proximity Label-MS Homo sapiens
81 LATS1  
Proximity Label-MS Homo sapiens
82 ANAPC2 29882
Proximity Label-MS Homo sapiens
83 MIF 4282
Affinity Capture-MS Homo sapiens
84 RBFOX2 23543
Two-hybrid Homo sapiens
85 TRIM37  
Proximity Label-MS Homo sapiens
86 KDM1A 23028
Proximity Label-MS Homo sapiens
87 CNOT8  
Affinity Capture-Western Homo sapiens
88 PXN 5829
Proximity Label-MS Homo sapiens
89 CLTA 1211
Proximity Label-MS Homo sapiens
90 SERBP1 26135
Proximity Label-MS Homo sapiens
91 MLLT4 4301
Proximity Label-MS Homo sapiens
View the network image/svg+xml
 Pathways in which TNRC6A is involved
PathwayEvidenceSource
Adherens junctions interactions TAS Reactome
Adherens junctions interactions IEA Reactome
Beta-catenin independent WNT signaling TAS Reactome
Ca2+ pathway TAS Reactome
Cell junction organization TAS Reactome
Cell junction organization IEA Reactome
Cell-Cell communication TAS Reactome
Cell-Cell communication IEA Reactome
Cell-cell junction organization TAS Reactome
Cell-cell junction organization IEA Reactome
Cellular responses to stimuli TAS Reactome
Cellular responses to stress TAS Reactome
Cellular Senescence TAS Reactome
Competing endogenous RNAs (ceRNAs) regulate PTEN translation TAS Reactome
Developmental Biology TAS Reactome
ESR-mediated signaling TAS Reactome
Estrogen-dependent gene expression TAS Reactome
Gene expression (Transcription) TAS Reactome
Gene expression (Transcription) IEA Reactome
Gene Silencing by RNA TAS Reactome
Generic Transcription Pathway TAS Reactome
Generic Transcription Pathway IEA Reactome
Intracellular signaling by second messengers TAS Reactome
MAPK family signaling cascades TAS Reactome
MAPK6/MAPK4 signaling TAS Reactome
MITF-M-dependent gene expression TAS Reactome
MITF-M-regulated melanocyte development TAS Reactome
NR1H2 and NR1H3-mediated signaling TAS Reactome
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux TAS Reactome
Oncogene Induced Senescence TAS Reactome
Oxidative Stress Induced Senescence TAS Reactome
PIP3 activates AKT signaling TAS Reactome
Post-transcriptional silencing by small RNAs TAS Reactome
Pre-NOTCH Expression and Processing TAS Reactome
Pre-NOTCH Transcription and Translation TAS Reactome
PTEN Regulation TAS Reactome
Regulation of CDH11 Expression and Function TAS Reactome
Regulation of CDH11 Expression and Function IEA Reactome
Regulation of CDH11 mRNA translation by microRNAs TAS Reactome
Regulation of CDH11 mRNA translation by microRNAs IEA Reactome
Regulation of Expression and Function of Type II Classical Cadherins TAS Reactome
Regulation of Expression and Function of Type II Classical Cadherins IEA Reactome
Regulation of Homotypic Cell-Cell Adhesion TAS Reactome
Regulation of Homotypic Cell-Cell Adhesion IEA Reactome
Regulation of MECP2 expression and activity IEA Reactome
Regulation of MITF-M-dependent genes involved in apoptosis TAS Reactome
Regulation of NPAS4 gene expression TAS Reactome
Regulation of NPAS4 mRNA translation TAS Reactome
Regulation of PTEN mRNA translation TAS Reactome
Regulation of RUNX1 Expression and Activity TAS Reactome
RNA Polymerase II Transcription TAS Reactome
RNA Polymerase II Transcription IEA Reactome
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function TAS Reactome
Signal Transduction TAS Reactome
Signaling by NOTCH TAS Reactome
Signaling by Nuclear Receptors TAS Reactome
Signaling by TGFB family members TAS Reactome
Signaling by TGFBR3 TAS Reactome
Signaling by WNT TAS Reactome
TGFBR3 expression TAS Reactome
TP53 Regulates Metabolic Genes TAS Reactome
Transcriptional Regulation by MECP2 TAS Reactome
Transcriptional Regulation by MECP2 IEA Reactome
Transcriptional Regulation by NPAS4 TAS Reactome
Transcriptional regulation by RUNX1 TAS Reactome
Transcriptional regulation by small RNAs TAS Reactome
Transcriptional Regulation by TP53 TAS Reactome
Transcriptional Regulation by VENTX TAS Reactome





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