Gene description for SKIV2L2
Gene name superkiller viralicidic activity 2-like 2 (S. cerevisiae)
Gene symbol SKIV2L2
Other names/aliases Dob1
KIAA0052
Mtr4
fSAP118
Species Homo sapiens
 Database cross references - SKIV2L2
ExoCarta ExoCarta_23517
Entrez Gene 23517
HGNC 18734
UniProt P42285  
 SKIV2L2 identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
Thymus 23844026    
 Gene ontology annotations for SKIV2L2
Molecular Function
    helicase activity GO:0004386 IEA
    protein binding GO:0005515 IPI
    poly(A) RNA binding GO:0044822 IDA
    ATP binding GO:0005524 IEA
Biological Process
    maturation of 5.8S rRNA GO:0000460 IMP
    mRNA splicing, via spliceosome GO:0000398 IC
Subcellular Localization
    catalytic step 2 spliceosome GO:0071013 IDA
    exosome (RNase complex) GO:0000178 IDA
    nucleus GO:0005634 IDA
    nucleolus GO:0005730 IEA
    nucleoplasm GO:0005654 IDA
 Experiment description of studies that identified SKIV2L2 in exosomes
1
Experiment ID 211
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
EpCAM|TFRC
EV Membrane markers
cytochrome c|GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
ISEV standards
CEM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
EpCAM|TFRC
EV Membrane markers
Cytochrome C|GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 217
ISEV standards
EM
EV Biophysical techniques
TSG101
EV Cytosolic markers
CD81|CD9|CD63
EV Membrane markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for SKIV2L2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 MPP6 51678
Two-hybrid Homo sapiens
2 RNPS1 10921
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which SKIV2L2 is involved
No pathways found





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