Gene description for EXOSC3
Gene name	exosome component 3
Gene symbol	EXOSC3
Other names/aliases	CGI-102 PCH1B RRP40 Rrp40p bA3J10.7 hRrp-40 p10
Species	Homo sapiens
Database cross references - EXOSC3
ExoCarta	ExoCarta_51010
Vesiclepedia	VP_51010
Entrez Gene	51010
HGNC	17944
MIM	606489
UniProt	Q9NQT5
EXOSC3 identified in sEVs derived from the following tissue/cell type
Squamous carcinoma cells	20124223
Thymus	23844026

Gene ontology annotations for EXOSC3

Molecular Function     3'-5'-RNA exonuclease activity GO:0000175 NAS     RNA binding GO:0003723 IBA     RNA exonuclease activity GO:0004532 IDA     protein binding GO:0005515 IPI Biological Process     exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) GO:0000467 IBA     nuclear-transcribed mRNA catabolic process GO:0000956 IBA     rRNA processing GO:0006364 IDA     RNA processing GO:0006396 IDA     RNA catabolic process GO:0006401 IDA     mRNA catabolic process GO:0006402 IMP     U4 snRNA 3'-end processing GO:0034475 IBA     DNA deamination GO:0045006 IDA     isotype switching GO:0045190 ISS     positive regulation of isotype switching GO:0045830 IEA     CUT catabolic process GO:0071034 IBA     CUT catabolic process GO:0071034 IMP     nuclear polyadenylation-dependent rRNA catabolic process GO:0071035 IBA     TRAMP-dependent tRNA surveillance pathway GO:0071038 IBA     poly(A)-dependent snoRNA 3'-end processing GO:0071051 IBA Subcellular Localization     nuclear exosome (RNase complex) GO:0000176 IBA     nuclear exosome (RNase complex) GO:0000176 IDA     nuclear exosome (RNase complex) GO:0000176 NAS     cytoplasmic exosome (RNase complex) GO:0000177 IBA     cytoplasmic exosome (RNase complex) GO:0000177 IDA     cytoplasmic exosome (RNase complex) GO:0000177 NAS     exosome (RNase complex) GO:0000178 IDA     exosome (RNase complex) GO:0000178 NAS     euchromatin GO:0000791 IMP     nucleus GO:0005634 IDA     nucleoplasm GO:0005654 IDA     nucleoplasm GO:0005654 TAS     nucleolus GO:0005730 IDA     cytoplasm GO:0005737 IDA     cytosol GO:0005829 IDA     cytosol GO:0005829 TAS     nucleolar exosome (RNase complex) GO:0101019 NAS