Gene description for EXOSC3
Gene name	exosome component 3
Gene symbol	EXOSC3
Other names/aliases	CGI-102 PCH1B RRP40 Rrp40p bA3J10.7 hRrp-40 p10
Species	Homo sapiens
Database cross references - EXOSC3
ExoCarta	ExoCarta_51010
Entrez Gene	51010
HGNC	17944
MIM	606489
UniProt	Q9NQT5
EXOSC3 identified in exosomes derived from the following tissue/cell type
Squamous carcinoma cells	20124223
Thymus	23844026

Gene ontology annotations for EXOSC3

Molecular Function     RNA binding GO:0003723 IBA     3'-5'-exoribonuclease activity GO:0000175 NAS     exoribonuclease activity GO:0004532 IDA     protein binding GO:0005515 IPI Biological Process     positive regulation of isotype switching GO:0045830 IEA     isotype switching GO:0045190 ISS     nuclear retention of pre-mRNA with aberrant 3'-ends at the site of transcription GO:0071049 IBA     nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' GO:0034427 IBA     U4 snRNA 3'-end processing GO:0034475 IBA     exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay GO:0043928 TAS     gene expression GO:0010467 TAS     nuclear polyadenylation-dependent tRNA catabolic process GO:0071038 IBA     exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) GO:0000467 IBA     rRNA processing GO:0006364 IDA     CUT catabolic process GO:0071034 IMP     nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 TAS     DNA deamination GO:0045006 IDA     polyadenylation-dependent snoRNA 3'-end processing GO:0071051 IBA     nuclear polyadenylation-dependent rRNA catabolic process GO:0071035 IBA Subcellular Localization     nucleus GO:0005634 IDA     cytoplasm GO:0005737 IDA     nucleolus GO:0005730 IDA     cytosol GO:0005829 TAS     exosome (RNase complex) GO:0000178 IDA     cytoplasmic exosome (RNase complex) GO:0000177 IDA     nuclear exosome (RNase complex) GO:0000176 IDA     transcriptionally active chromatin GO:0035327 IMP