Gene description for RASSF2
Gene name Ras association (RalGDS/AF-6) domain family member 2
Gene symbol RASSF2
Other names/aliases CENP-34
RASFADIN
Species Homo sapiens
 Database cross references - RASSF2
ExoCarta ExoCarta_9770
Vesiclepedia VP_9770
Entrez Gene 9770
HGNC 9883
MIM 609492
UniProt P50749  
 RASSF2 identified in exosomes derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for RASSF2
Molecular Function
    protein kinase activity GO:0004672 IGI
    protein binding GO:0005515 IPI
Biological Process
    skeletal system development GO:0001501 IEA
    ossification GO:0001503 IEA
    signal transduction GO:0007165 IBA
    canonical NF-kappaB signal transduction GO:0007249 IEA
    positive regulation of protein autophosphorylation GO:0031954 IDA
    negative regulation of peptidyl-serine phosphorylation GO:0033137 IDA
    positive regulation of apoptotic process GO:0043065 IDA
    regulation of osteoblast differentiation GO:0045667 IEA
    regulation of osteoclast differentiation GO:0045670 IEA
    positive regulation of protein kinase activity GO:0045860 IDA
    positive regulation of JNK cascade GO:0046330 IBA
    positive regulation of JNK cascade GO:0046330 IDA
    bone remodeling GO:0046849 IEA
    homeostasis of number of cells GO:0048872 IEA
    protein stabilization GO:0050821 IMP
    regulation of non-canonical NF-kappaB signal transduction GO:1901222 IBA
    negative regulation of non-canonical NF-kappaB signal transduction GO:1901223 IEA
Subcellular Localization
    kinetochore GO:0000776 IDA
    nucleus GO:0005634 IBA
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 IDA
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 IDA
    Golgi apparatus GO:0005794 IDA
    cytosol GO:0005829 IDA
    plasma membrane GO:0005886 IDA
    protein-containing complex GO:0032991 IDA
 Experiment description of studies that identified RASSF2 in exosomes
1
Experiment ID 217
MISEV standards
EM
Biophysical techniques
TSG101|CD81|CD9|CD63
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for RASSF2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 YWHAH 7533
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 CALML3 810
Affinity Capture-MS Homo sapiens
3 EMB 133418
Affinity Capture-MS Homo sapiens
4 MOB1A 55233
Affinity Capture-MS Homo sapiens
5 STK3 6788
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 PPP3R1 5534
Affinity Capture-MS Homo sapiens
7 CEP131 22994
Proximity Label-MS Homo sapiens
8 MOB1B 92597
Affinity Capture-MS Homo sapiens
9 YWHAZ 7534
Affinity Capture-MS Homo sapiens
10 YWHAB 7529
Affinity Capture-MS Homo sapiens
11 YWHAE 7531
Affinity Capture-MS Homo sapiens
12 AKAP9 10142
Proximity Label-MS Homo sapiens
13 PRMT6  
Two-hybrid Homo sapiens
14 PTEN 5728
Synthetic Growth Defect Homo sapiens
15 RASSF1  
Affinity Capture-MS Homo sapiens
16 TAOK1 57551
Affinity Capture-MS Homo sapiens
17 SUV39H1  
Two-hybrid Homo sapiens
18 PPP3CA 5530
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 PRMT3 10196
Two-hybrid Homo sapiens
20 OFD1 8481
Proximity Label-MS Homo sapiens
21 PPP1R9A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 BIRC6 57448
Proximity Label-MS Homo sapiens
23 KDM1A 23028
Two-hybrid Homo sapiens
24 HDAC6 10013
Proximity Label-MS Homo sapiens
25 SAV1  
Affinity Capture-MS Homo sapiens
26 STK4 6789
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
27 SPRR2E  
Affinity Capture-MS Homo sapiens
28 PPP3CB  
Affinity Capture-MS Homo sapiens
29 C1QBP 708
Affinity Capture-MS Homo sapiens
30 YWHAQ 10971
Affinity Capture-MS Homo sapiens
31 KRAS 3845
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
32 COA7  
Affinity Capture-MS Homo sapiens
33 YWHAG 7532
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 S100Z  
Two-hybrid Homo sapiens
35 RASSF5 83593
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which RASSF2 is involved
No pathways found





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