Gene description for ZNF205
Gene name zinc finger protein 205
Gene symbol ZNF205
Other names/aliases RhitH
ZNF210
Zfp13
Species Homo sapiens
 Database cross references - ZNF205
ExoCarta ExoCarta_7755
Vesiclepedia VP_7755
Entrez Gene 7755
HGNC 12996
MIM 603436
UniProt O95201  
 ZNF205 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for ZNF205
Molecular Function
    sequence-specific DNA binding transcription factor activity GO:0003700 IBA
    protein binding GO:0005515 IPI
    zinc ion binding GO:0008270 NAS
    DNA binding GO:0003677 IEA
Biological Process
    positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway GO:1901030 IMP
    regulation of transcription, DNA-templated GO:0006355 NAS
    negative regulation of transcription from RNA polymerase II promoter GO:0000122 IMP
    positive regulation of hydrogen peroxide biosynthetic process GO:0010729 IMP
    transcription, DNA-templated GO:0006351 IEA
Subcellular Localization
    nucleus GO:0005634 IEA
 Experiment description of studies that identified ZNF205 in exosomes
1
Experiment ID 235
MISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
EV Enriched markers
✔
HSP90B1
EV Negative markers
✔
qNano
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for ZNF205
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TRAF2 7186
Two-hybrid Homo sapiens
2 DIPA  
Two-hybrid Homo sapiens
3 NDP52  
Two-hybrid Homo sapiens
4 MDFI  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which ZNF205 is involved
PathwayEvidenceSource
Generic Transcription Pathway TAS Reactome





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