Gene description for DYSF
Gene name dysferlin
Gene symbol DYSF
Other names/aliases FER1L1
LGMD2B
MMD1
Species Homo sapiens
 Database cross references - DYSF
ExoCarta ExoCarta_8291
Entrez Gene 8291
HGNC 3097
MIM 603009
UniProt O75923  
 DYSF identified in exosomes derived from the following tissue/cell type
Urine 19056867    
 Gene ontology annotations for DYSF
Molecular Function
    calcium-dependent phospholipid binding GO:0005544 IMP
    calcium ion binding GO:0005509 IDA
    phospholipid binding GO:0005543 IDA
    protein binding GO:0005515 IPI
Biological Process
    vesicle fusion GO:0006906 IEA
    plasma membrane repair GO:0001778 IEA
Subcellular Localization
    integral component of membrane GO:0016021 IEA
    cytoplasmic vesicle membrane GO:0030659 TAS
    late endosome GO:0005770 IDA
    endocytic vesicle GO:0030139 IDA
    lamellipodium GO:0030027 IEA
    extracellular exosome GO:0070062 IDA
    early endosome GO:0005769 IDA
    sarcolemma GO:0042383 IDA
    T-tubule GO:0030315 IDA
    plasma membrane GO:0005886 IDA
    endosome GO:0005768 IDA
 Experiment description of studies that identified DYSF in exosomes
1
Experiment ID 63
ISEV standards
✘ EV Biophysical techniques
✘ EV Cytosolic markers
✔
AQP2
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for DYSF
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CAV3  
Invivo Homo sapiens
Invitro Homo sapiens
View the network image/svg+xml
 Pathways in which DYSF is involved
PathwayEvidenceSource
Muscle contraction TAS Reactome





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