Gene description for SIRT2
Gene name sirtuin 2
Gene symbol SIRT2
Other names/aliases SIR2
SIR2L
SIR2L2
Species Homo sapiens
 Database cross references - SIRT2
ExoCarta ExoCarta_22933
Vesiclepedia VP_22933
Entrez Gene 22933
HGNC 10886
MIM 604480
UniProt Q8IXJ6  
 SIRT2 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Hepatocytes 26054723    
 Gene ontology annotations for SIRT2
Molecular Function
    chromatin binding GO:0003682 IDA
    NAD+-protein poly-ADP-ribosyltransferase activity GO:0003950 IDA
    NAD+-protein poly-ADP-ribosyltransferase activity GO:0003950 TAS
    histone deacetylase activity GO:0004407 IDA
    protein binding GO:0005515 IPI
    zinc ion binding GO:0008270 IDA
    histone deacetylase activity, NAD-dependent GO:0017136 IBA
    histone deacetylase activity, NAD-dependent GO:0017136 IDA
    histone deacetylase activity, NAD-dependent GO:0017136 IDA
    histone H3K14 deacetylase activity, NAD-dependent GO:0032041 IEA
    protein lysine deacetylase activity GO:0033558 IDA
    protein lysine deacetylase activity GO:0033558 IMP
    NAD-dependent protein lysine deacetylase activity GO:0034979 IDA
    NAD-dependent protein lysine deacetylase activity GO:0034979 IMP
    NAD-dependent protein lysine deacetylase activity GO:0034979 TAS
    histone acetyltransferase binding GO:0035035 IPI
    histone deacetylase binding GO:0042826 IPI
    tubulin deacetylase activity GO:0042903 IDA
    tubulin deacetylase activity GO:0042903 IDA
    ubiquitin binding GO:0043130 IDA
    histone H3K9 deacetylase activity, NAD-dependent GO:0046969 IEA
    histone H4K16 deacetylase activity, NAD-dependent GO:0046970 IDA
    NAD+ binding GO:0070403 IBA
    NAD+ binding GO:0070403 IDA
    histone H3K18 deacetylase activity, NAD-dependent GO:0097372 IEA
    DNA-binding transcription factor binding GO:0140297 IPI
    histone H3K56 deacetylase activity, NAD-dependent GO:0140765 IEA
    NAD-dependent protein demyristoylase activity GO:0140773 IDA
    NAD-dependent protein depalmitoylase activity GO:0140774 IDA
    histone H3K4 deacetylase activity, NAD-dependent GO:0141222 IEA
    NAD+-protein ADP-ribosyltransferase activity GO:1990404 TAS
Biological Process
    negative regulation of transcription by RNA polymerase II GO:0000122 IDA
    negative regulation of transcription by RNA polymerase II GO:0000122 IMP
    rDNA heterochromatin formation GO:0000183 IBA
    rDNA heterochromatin formation GO:0000183 NAS
    protein deacetylation GO:0006476 IDA
    protein deacetylation GO:0006476 IDA
    autophagy GO:0006914 IEA
    mitotic nuclear membrane reassembly GO:0007084 TAS
    regulation of exit from mitosis GO:0007096 NAS
    negative regulation of autophagy GO:0010507 IMP
    negative regulation of peptidyl-threonine phosphorylation GO:0010801 ISS
    lipid catabolic process GO:0016042 ISS
    substantia nigra development GO:0021762 HEP
    myelination in peripheral nervous system GO:0022011 ISS
    heterochromatin formation GO:0031507 NAS
    subtelomeric heterochromatin formation GO:0031509 NAS
    regulation of myelination GO:0031641 ISS
    positive regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032436 IMP
    positive regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032436 ISS
    cellular response to oxidative stress GO:0034599 ISS
    peptidyl-lysine deacetylation GO:0034983 IDA
    epigenetic regulation of gene expression GO:0040029 IMP
    negative regulation of protein catabolic process GO:0042177 IMP
    regulation of phosphorylation GO:0042325 NAS
    proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161 IMP
    positive regulation of DNA binding GO:0043388 ISS
    post-translational protein modification GO:0043687 IEA
    NLRP3 inflammasome complex assembly GO:0044546 IEA
    innate immune response GO:0045087 IEA
    negative regulation of fat cell differentiation GO:0045599 ISS
    positive regulation of fatty acid biosynthetic process GO:0045723 IDA
    positive regulation of meiotic nuclear division GO:0045836 ISS
    negative regulation of striated muscle tissue development GO:0045843 IDA
    negative regulation of DNA-templated transcription GO:0045892 IDA
    positive regulation of transcription by RNA polymerase II GO:0045944 ISS
    cell division GO:0051301 IEA
    meiotic cell cycle GO:0051321 IEA
    regulation of cell cycle GO:0051726 IMP
    response to redox state GO:0051775 NAS
    positive regulation of cell division GO:0051781 ISS
    positive regulation of attachment of spindle microtubules to kinetochore GO:0051987 ISS
    cellular response to caloric restriction GO:0061433 ISS
    negative regulation of oligodendrocyte progenitor proliferation GO:0070446 ISS
    cellular response to hypoxia GO:0071456 IDA
    cellular response to epinephrine stimulus GO:0071872 ISS
    tubulin deacetylation GO:0090042 IDA
    tubulin deacetylation GO:0090042 IDA
    tubulin deacetylation GO:0090042 ISS
    positive regulation of execution phase of apoptosis GO:1900119 ISS
    positive regulation of oocyte maturation GO:1900195 ISS
    negative regulation of NLRP3 inflammasome complex assembly GO:1900226 IEA
    negative regulation of satellite cell differentiation GO:1902725 ISS
    negative regulation of reactive oxygen species metabolic process GO:2000378 ISS
Subcellular Localization
    chromosome, telomeric region GO:0000781 IEA
    heterochromatin GO:0000792 ISS
    nucleus GO:0005634 IBA
    nucleus GO:0005634 IDA
    chromatin silencing complex GO:0005677 NAS
    chromosome GO:0005694 IDA
    nucleolus GO:0005730 IDA
    cytoplasm GO:0005737 IDA
    mitochondrion GO:0005739 HTP
    centrosome GO:0005813 IDA
    centriole GO:0005814 IDA
    spindle GO:0005819 IDA
    cytosol GO:0005829 IDA
    cytosol GO:0005829 TAS
    microtubule GO:0005874 IDA
    plasma membrane GO:0005886 IDA
    growth cone GO:0030426 IEA
    midbody GO:0030496 IDA
    paranodal junction GO:0033010 ISS
    paranode region of axon GO:0033270 ISS
    perikaryon GO:0043204 ISS
    myelin sheath GO:0043209 ISS
    lateral loop GO:0043219 ISS
    Schmidt-Lanterman incisure GO:0043220 ISS
    juxtaparanode region of axon GO:0044224 ISS
    perinuclear region of cytoplasm GO:0048471 ISS
    mitotic spindle GO:0072686 IDA
    meiotic spindle GO:0072687 ISS
    glial cell projection GO:0097386 ISS
 Experiment description of studies that identified SIRT2 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 237
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
Enriched markers
✔
HSP90B1
Negative markers
✔
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for SIRT2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 MORC2  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
2 ATR  
Affinity Capture-Western Homo sapiens
3 ACTR2 10097
Proximity Label-MS Homo sapiens
4 HSD17B11 51170
Proximity Label-MS Homo sapiens
5 PPP1CB 5500
Affinity Capture-MS Homo sapiens
6 CLIP1 6249
Proximity Label-MS Homo sapiens
7 BAG3 9531
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
8 GART 2618
Affinity Capture-MS Homo sapiens
9 CST5 1473
Affinity Capture-MS Homo sapiens
10 MARCKS 4082
Proximity Label-MS Homo sapiens
11 DYNC1I2 1781
Proximity Label-MS Homo sapiens
12 SEPT10 151011
Proximity Label-MS Homo sapiens
13 TPM2 7169
Affinity Capture-MS Homo sapiens
14 RPA2 6118
Proximity Label-MS Homo sapiens
15 GFAP 2670
Proximity Label-MS Homo sapiens
16 ART1 417
Affinity Capture-MS Homo sapiens
17 ORC2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 SYVN1 84447
Affinity Capture-Western Homo sapiens
19 RTN4 57142
Affinity Capture-MS Homo sapiens
20 DNAJB6 10049
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
21 DEGS1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 ELL  
Affinity Capture-MS Homo sapiens
23 PCK1 5105
Affinity Capture-Western Homo sapiens
24 FZR1  
Biochemical Activity Homo sapiens
25 SIRT1  
Affinity Capture-Western Homo sapiens
26 TINF2  
Affinity Capture-MS Homo sapiens
27 KRT78 196374
Affinity Capture-MS Homo sapiens
28 GSTT2B 653689
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
29 MTDH 92140
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 RBP1 5947
Affinity Capture-Western Homo sapiens
31 CBLB 868
Affinity Capture-Western Homo sapiens
32 EBAG9 9166
Proximity Label-MS Homo sapiens
33 LAMTOR1 55004
Proximity Label-MS Homo sapiens
34 HSPA8 3312
Affinity Capture-MS Homo sapiens
35 DMD 1756
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
36 XPO1 7514
Affinity Capture-MS Homo sapiens
37 ACTA2 59
Affinity Capture-MS Homo sapiens
38 MANSC1 54682
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
39 MTCH2 23788
Proximity Label-MS Homo sapiens
40 PRPH 5630
Proximity Label-MS Homo sapiens
41 GCKR  
Affinity Capture-Western Homo sapiens
42 FADS1 3992
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
43 CBL 867
Affinity Capture-Western Homo sapiens
44 TUFM 7284
Affinity Capture-MS Homo sapiens
45 OXTR 5021
Two-hybrid Homo sapiens
46 DNAJB8  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
47 SNRPD1 6632
Affinity Capture-MS Homo sapiens
48 MOAP1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
49 RAN 5901
Affinity Capture-MS Homo sapiens
50 GYS1 2997
Affinity Capture-MS Homo sapiens
51 SLC22A23  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
52 RAB3GAP1 22930
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
53 PHGDH 26227
Biochemical Activity Homo sapiens
54 AGPS 8540
Proximity Label-MS Homo sapiens
55 VDAC2 7417
Affinity Capture-MS Homo sapiens
56 HIST1H2AB 8335
Affinity Capture-MS Homo sapiens
57 RMDN3 55177
Proximity Label-MS Homo sapiens
58 SLC25A5 292
Affinity Capture-MS Homo sapiens
59 REEP5 7905
Proximity Label-MS Homo sapiens
60 FBXL4 26235
Proximity Label-MS Homo sapiens
61 HIST1H3A 8350
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
62 ACLY 47
Affinity Capture-Western Homo sapiens
63 NUDT12  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
64 PLA2G4A 5321
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
65 PANX1 24145
Proximity Label-MS Homo sapiens
66 FOXO1  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
67 ZNF252P-AS1  
Affinity Capture-MS Homo sapiens
68 SKP2  
Affinity Capture-Western Homo sapiens
69 STIM1 6786
Proximity Label-MS Homo sapiens
70 GPAM 57678
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
71 ATRIP  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
72 KIAA0930  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
73 RPL7 6129
Affinity Capture-MS Homo sapiens
74 RUNX3  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
75 OCIAD1 54940
Proximity Label-MS Homo sapiens
76 RP9  
Affinity Capture-MS Homo sapiens
77 CDK2 1017
Biochemical Activity Homo sapiens
78 RPA3 6119
Proximity Label-MS Homo sapiens
79 TRAPPC12 51112
Affinity Capture-MS Homo sapiens
80 SIRT2 22933
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
81 SARS 6301
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
82 Kctd5  
Affinity Capture-MS Mus musculus
83 CTNNA1 1495
Proximity Label-MS Homo sapiens
84 HSPD1 3329
Affinity Capture-MS Homo sapiens
85 AKT1 207
Affinity Capture-Western Homo sapiens
86 KRT19 3880
Proximity Label-MS Homo sapiens
87 KRT2 3849
Affinity Capture-MS Homo sapiens
88 MDM2  
Biochemical Activity Homo sapiens
89 GSTT1 2952
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
90 AHSA1 10598
Affinity Capture-MS Homo sapiens
91 NUDT21 11051
Affinity Capture-Western Homo sapiens
92 FBXL6  
Proximity Label-MS Homo sapiens
93 PHB2 11331
Affinity Capture-MS Homo sapiens
94 SPOP  
Affinity Capture-MS Homo sapiens
95 CDC20 991
Biochemical Activity Homo sapiens
96 PARP1 142
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
97 PAPOLA 10914
Affinity Capture-Western Homo sapiens
98 SNAI1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
99 RAB3GAP2 25782
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
100 SCFD2 152579
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
101 HORMAD2  
Affinity Capture-MS Homo sapiens
102 HDAC6 10013
Affinity Capture-Western Homo sapiens
103 KAT2B  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
104 SQSTM1 8878
Proximity Label-MS Homo sapiens
105 DCTN2 10540
Proximity Label-MS Homo sapiens
106 C11orf52 91894
Proximity Label-MS Homo sapiens
107 MAP2K1 5604
Affinity Capture-Western Homo sapiens
108 ANAPC2 29882
Proximity Label-MS Homo sapiens
109 VAMP7 6845
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
110 ING1  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
111 KRT8 3856
Proximity Label-MS Homo sapiens
112 SRSF7 6432
Affinity Capture-MS Homo sapiens
113 CUL4A 8451
Affinity Capture-MS Homo sapiens
114 ANK3  
Proximity Label-MS Homo sapiens
115 C17orf59 54785
Proximity Label-MS Homo sapiens
116 EP300 2033
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
117 DERL1 79139
Proximity Label-MS Homo sapiens
View the network image/svg+xml



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