Gene description for SIRT2
Gene name sirtuin 2
Gene symbol SIRT2
Other names/aliases SIR2
Species Homo sapiens
 Database cross references - SIRT2
ExoCarta ExoCarta_22933
Entrez Gene 22933
HGNC 10886
MIM 604480
UniProt Q8IXJ6  
 SIRT2 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for SIRT2
Molecular Function
    tubulin deacetylase activity GO:0042903 IDA
    NAD+ binding GO:0070403 IDA
    NAD-dependent histone deacetylase activity GO:0017136 IDA
    beta-tubulin binding GO:0048487 IEA
    zinc ion binding GO:0008270 IDA
    protein deacetylase activity GO:0033558 IMP
    chromatin binding GO:0003682 IDA
    transcription factor binding GO:0008134 IPI
    histone deacetylase activity GO:0004407 IDA
    histone deacetylase binding GO:0042826 IPI
    NAD-dependent histone deacetylase activity (H4-K16 specific) GO:0046970 IDA
    histone acetyltransferase binding GO:0035035 IPI
    ubiquitin binding GO:0043130 IDA
    protein binding GO:0005515 IPI
    NAD-dependent protein deacetylase activity GO:0034979 IMP
    NAD+ ADP-ribosyltransferase activity GO:0003950 TAS
Biological Process
    positive regulation of attachment of spindle microtubules to kinetochore GO:0051987 ISS
    cellular response to caloric restriction GO:0061433 ISS
    negative regulation of fat cell differentiation GO:0045599 ISS
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 ISS
    cellular lipid catabolic process GO:0044242 ISS
    cellular response to epinephrine stimulus GO:0071872 ISS
    regulation of exit from mitosis GO:0007096 NAS
    response to redox state GO:0051775 NAS
    myelination in peripheral nervous system GO:0022011 ISS
    positive regulation of meiotic nuclear division GO:0045836 ISS
    negative regulation of striated muscle tissue development GO:0045843 IDA
    hepatocyte growth factor receptor signaling pathway GO:0048012 IDA
    positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia GO:2000777 IMP
    autophagy GO:0006914 IEA
    regulation of myelination GO:0031641 ISS
    positive regulation of cell division GO:0051781 ISS
    negative regulation of autophagy GO:0010507 IMP
    chromatin silencing at rDNA GO:0000183 NAS
    negative regulation of transcription, DNA-templated GO:0045892 IDA
    negative regulation of NLRP3 inflammasome complex assembly GO:1900226 IEA
    negative regulation of transcription from RNA polymerase II promoter GO:0000122 IMP
    negative regulation of reactive oxygen species metabolic process GO:2000378 ISS
    histone H3 deacetylation GO:0070932 IMP
    negative regulation of transcription from RNA polymerase II promoter in response to hypoxia GO:0061428 IMP
    substantia nigra development GO:0021762 IEP
    protein kinase B signaling GO:0043491 IMP
    negative regulation of oligodendrocyte progenitor proliferation GO:0070446 ISS
    proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161 IMP
    negative regulation of defense response to bacterium GO:1900425 IMP
    regulation of phosphorylation GO:0042325 NAS
    histone deacetylation GO:0016575 TAS
    negative regulation of protein catabolic process GO:0042177 IMP
    mitotic nuclear division GO:0007067 IEA
    peptidyl-lysine deacetylation GO:0034983 IDA
    cellular response to hepatocyte growth factor stimulus GO:0035729 IDA
    positive regulation of oocyte maturation GO:1900195 ISS
    cellular response to oxidative stress GO:0034599 ISS
    transcription, DNA-templated GO:0006351 IEA
    negative regulation of cell proliferation GO:0008285 IMP
    phosphatidylinositol 3-kinase signaling GO:0014065 IMP
    gene silencing GO:0016458 NAS
    protein ADP-ribosylation GO:0006471 TAS
    positive regulation of DNA binding GO:0043388 ISS
    histone H4 deacetylation GO:0070933 IDA
    negative regulation of peptidyl-threonine phosphorylation GO:0010801 ISS
    cellular response to hypoxia GO:0071456 IDA
    protein deacetylation GO:0006476 IMP
    cellular response to molecule of bacterial origin GO:0071219 IDA
    innate immune response GO:0045087 IEA
    ripoptosome assembly involved in necroptotic process GO:1901026 IEA
    positive regulation of execution phase of apoptosis GO:1900119 ISS
    chromatin silencing at telomere GO:0006348 NAS
    regulation of cell cycle GO:0051726 IMP
    cell division GO:0051301 IEA
    meiotic cell cycle GO:0051321 IEA
    chromatin silencing GO:0006342 NAS
    tubulin deacetylation GO:0090042 ISS
    positive regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032436 ISS
Subcellular Localization
    lateral loop GO:0043219 ISS
    juxtaparanode region of axon GO:0044224 ISS
    centriole GO:0005814 IDA
    perikaryon GO:0043204 ISS
    mitotic spindle GO:0072686 IDA
    cytosol GO:0005829 IDA
    chromatin silencing complex GO:0005677 NAS
    midbody GO:0030496 IDA
    Schmidt-Lanterman incisure GO:0043220 ISS
    glial cell projection GO:0097386 ISS
    paranode region of axon GO:0033270 ISS
    spindle GO:0005819 IDA
    myelin sheath GO:0043209 ISS
    perinuclear region of cytoplasm GO:0048471 ISS
    centrosome GO:0005813 IDA
    chromosome GO:0005694 IDA
    meiotic spindle GO:0072687 ISS
    growth cone GO:0030426 IEA
    paranodal junction GO:0033010 ISS
    plasma membrane GO:0005886 IEA
    nuclear heterochromatin GO:0005720 ISS
    nucleus GO:0005634 IDA
    cytoplasm GO:0005737 IDA
    microtubule GO:0005874 IDA
 Experiment description of studies that identified SIRT2 in exosomes
Experiment ID 237
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for SIRT2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TUBB  
Biochemical Activity Homo sapiens
2 HDAC6 10013
Affinity Capture-MS Homo sapiens
3 ELL  
Affinity Capture-MS Homo sapiens
4 PHB2 11331
Affinity Capture-MS Homo sapiens
5 SPOP  
Affinity Capture-MS Homo sapiens
6 SARS 6301
Affinity Capture-MS Homo sapiens
7 SIRT2 22933
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 KRT78 196374
Affinity Capture-MS Homo sapiens
9 GYS1 2997
Affinity Capture-MS Homo sapiens
10 RTN4 57142
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which SIRT2 is involved
No pathways found

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