Gene description for OXTR
Gene name oxytocin receptor
Gene symbol OXTR
Other names/aliases OT-R
Species Homo sapiens
 Database cross references - OXTR
ExoCarta ExoCarta_5021
Entrez Gene 5021
HGNC 8529
MIM 167055
UniProt P30559  
 OXTR identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells Unpublished / Not applicable
 Gene ontology annotations for OXTR
Molecular Function
    peptide binding GO:0042277 IBA
    vasopressin receptor activity GO:0005000 IBA
    oxytocin receptor activity GO:0004990 IEA
    peptide hormone binding GO:0017046 IEA
Biological Process
    G-protein coupled receptor signaling pathway GO:0007186 IBA
    suckling behavior GO:0001967 IEA
    response to drug GO:0042493 IEA
    positive regulation of synapse assembly GO:0051965 IEA
    maternal process involved in parturition GO:0060137 IEA
    response to progesterone GO:0032570 IEA
    telencephalon development GO:0021537 IEA
    lactation GO:0007595 TAS
    maternal behavior GO:0042711 IBA
    regulation of systemic arterial blood pressure by vasopressin GO:0001992 IBA
    sperm ejaculation GO:0042713 IEA
    response to peptide hormone GO:0043434 IEA
    female pregnancy GO:0007565 IEA
    social behavior GO:0035176 IBA
    ERK1 and ERK2 cascade GO:0070371 IEA
    positive regulation of blood pressure GO:0045777 IEA
    positive regulation of synaptic transmission, GABAergic GO:0032230 IEA
    response to cocaine GO:0042220 IEA
    heart development GO:0007507 IEA
    sleep GO:0030431 IEA
    positive regulation of cytosolic calcium ion concentration GO:0007204 IEA
    negative regulation of gastric acid secretion GO:0060455 IEA
    response to estradiol GO:0032355 IEA
    response to cytokine GO:0034097 IEA
    cell surface receptor signaling pathway GO:0007166 TAS
    cellular response to hormone stimulus GO:0032870 IBA
    digestive tract development GO:0048565 IEA
    positive regulation of penile erection GO:0060406 IEA
    response to anoxia GO:0034059 IEA
    response to amphetamine GO:0001975 IEA
    memory GO:0007613 IEA
    positive regulation of vasoconstriction GO:0045907 IBA
    positive regulation of uterine smooth muscle contraction GO:0070474 IEA
    positive regulation of synaptic transmission, glutamatergic GO:0051968 IEA
    muscle contraction GO:0006936 TAS
    positive regulation of norepinephrine secretion GO:0010701 IEA
    response to peptide GO:1901652 IBA
    eating behavior GO:0042755 IEA
Subcellular Localization
    integral component of plasma membrane GO:0005887 TAS
    cell-cell adherens junction GO:0005913 IEA
    cytosol GO:0005829 IEA
    plasma membrane GO:0005886 TAS
    apical plasma membrane GO:0016324 IEA
    microvillus GO:0005902 IEA
 Experiment description of studies that identified OXTR in exosomes
Experiment ID 126
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [LTQ-FT Ultra]
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
 Protein-protein interactions for OXTR
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 GRK5 2869
Affinity Capture-Western Homo sapiens
2 OXT  
Invitro Homo sapiens
View the network image/svg+xml
 Pathways in which OXTR is involved
G alpha (q) signalling events TAS Reactome
G alpha (q) signalling events TAS Reactome
Vasopressin-like receptors TAS Reactome

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