Gene description for HYPK
Gene name huntingtin interacting protein K
Gene symbol HYPK
Other names/aliases C15orf63
HSPC136
Species Homo sapiens
 Database cross references - HYPK
ExoCarta ExoCarta_25764
Vesiclepedia VP_25764
Entrez Gene 25764
HGNC 18418
MIM 612784
UniProt Q9NX55  
 HYPK identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for HYPK
Molecular Function
    protein binding GO:0005515 IPI
    protein folding chaperone GO:0044183 EXP
    protein folding chaperone GO:0044183 IDA
Biological Process
    protein folding GO:0006457 IEA
    negative regulation of apoptotic process GO:0043066 IBA
    negative regulation of apoptotic process GO:0043066 IDA
    protein stabilization GO:0050821 IBA
    protein stabilization GO:0050821 IDA
Subcellular Localization
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 IDA
    cytoplasm GO:0005737 IDA
    microtubule cytoskeleton GO:0015630 IDA
    protein-containing complex GO:0032991 IDA
 Experiment description of studies that identified HYPK in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for HYPK
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 RIT1 6016
Negative Genetic Homo sapiens
2 RPSAP58 388524
Affinity Capture-MS Homo sapiens
3 RBPMS 11030
Affinity Capture-MS Homo sapiens
4 PMAIP1  
Affinity Capture-MS Homo sapiens
5 MYOM3  
Affinity Capture-MS Homo sapiens
6 ZPR1 8882
Co-fractionation Homo sapiens
7 GC 2638
Affinity Capture-MS Homo sapiens
8 QKI 9444
Affinity Capture-MS Homo sapiens
9 MAGEA1  
Two-hybrid Homo sapiens
10 MDFI  
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
11 ETFB 2109
Cross-Linking-MS (XL-MS) Homo sapiens
12 HSP90AB1 3326
Affinity Capture-MS Homo sapiens
13 ARCN1 372
Affinity Capture-MS Homo sapiens
14 CALM1 801
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
15 RHOXF2  
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
16 DNAJB3 414061
Affinity Capture-MS Homo sapiens
17 APP 351
Reconstituted Complex Homo sapiens
18 TRIM28 10155
Co-fractionation Homo sapiens
19 NAA11 84779
Affinity Capture-MS Homo sapiens
20 Naa50  
Affinity Capture-MS Mus musculus
21 PHC3  
Two-hybrid Homo sapiens
22 ALPK2  
Affinity Capture-MS Homo sapiens
23 Naa10  
Affinity Capture-MS Mus musculus
24 PRR20A  
Two-hybrid Homo sapiens
25 UBQLN1 29979
Co-fractionation Homo sapiens
26 ZNF100  
Affinity Capture-MS Homo sapiens
27 Naa11  
Affinity Capture-MS Mus musculus
28 YEATS2  
Affinity Capture-MS Homo sapiens
29 KRTAP19-5  
Two-hybrid Homo sapiens
30 NME2 4831
Affinity Capture-MS Homo sapiens
31 CALR 811
Affinity Capture-MS Homo sapiens
32 ATP6V0A4 50617
Affinity Capture-MS Homo sapiens
33 CHD3 1107
Affinity Capture-MS Homo sapiens
34 CSNK2B 1460
Two-hybrid Homo sapiens
35 ZNF462  
Affinity Capture-MS Homo sapiens
36 PRR20C  
Two-hybrid Homo sapiens
37 EEF1A1 1915
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
38 Naa15 74838
Affinity Capture-MS Mus musculus
39 C2orf68  
Two-hybrid Homo sapiens
40 HSPA8 3312
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
41 PSME3 10197
Affinity Capture-MS Homo sapiens
42 KRTAP8-1  
Two-hybrid Homo sapiens
43 SEPHS1 22929
Co-fractionation Homo sapiens
44 TSGA10IP  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
45 IKBIP 121457
Affinity Capture-MS Homo sapiens
46 NAA50 80218
Affinity Capture-MS Homo sapiens
47 PPP6R2 9701
Affinity Capture-MS Homo sapiens
48 HTT 3064
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
49 SRRT 51593
Affinity Capture-MS Homo sapiens
50 RPA2 6118
Co-fractionation Homo sapiens
51 CYSRT1 375791
Two-hybrid Homo sapiens
52 IGHG4 3503
Affinity Capture-MS Homo sapiens
53 TPI1 7167
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
54 MYH11 4629
Cross-Linking-MS (XL-MS) Homo sapiens
55 BOLL  
Two-hybrid Homo sapiens
56 VENTX  
Two-hybrid Homo sapiens
57 MLF2 8079
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
58 MYL12A 10627
Co-fractionation Homo sapiens
59 KIF20B  
Affinity Capture-MS Homo sapiens
60 ZNF516 9658
Affinity Capture-MS Homo sapiens
61 GLUD2 2747
Affinity Capture-MS Homo sapiens
62 NAA16 79612
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
63 KRTAP3-3  
Two-hybrid Homo sapiens
64 DNAJC2 27000
Affinity Capture-MS Homo sapiens
65 NELFCD 51497
Affinity Capture-MS Homo sapiens
66 PRKAA2 5563
Cross-Linking-MS (XL-MS) Homo sapiens
67 LMNB2 84823
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
68 NAA15 80155
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-crystal Structure Homo sapiens
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
69 HSPA14 51182
Affinity Capture-MS Homo sapiens
70 PRR20D  
Two-hybrid Homo sapiens
71 THAP1  
Two-hybrid Homo sapiens
72 MLF1  
Affinity Capture-MS Homo sapiens
73 PRR20B  
Two-hybrid Homo sapiens
74 ATP5J2 9551
Affinity Capture-MS Homo sapiens
75 PCBP1 5093
Two-hybrid Homo sapiens
76 FAM46A  
Two-hybrid Homo sapiens
77 HSPA1A 3303
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
78 PGAM1 5223
Affinity Capture-MS Homo sapiens
79 KRTAP3-2  
Two-hybrid Homo sapiens
80 NAA10 8260
Affinity Capture-MS Homo sapiens
Co-crystal Structure Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
81 TXLNA 200081
Two-hybrid Homo sapiens
82 LBR 3930
Affinity Capture-MS Homo sapiens
83 RELA 5970
Affinity Capture-MS Homo sapiens
84 CEP290  
Affinity Capture-MS Homo sapiens
85 GLUD1 2746
Affinity Capture-MS Homo sapiens
86 FASN 2194
Positive Genetic Homo sapiens
87 C11orf58  
Co-fractionation Homo sapiens
88 TP53 7157
Affinity Capture-MS Homo sapiens
89 LENG8  
Affinity Capture-MS Homo sapiens
90 SECISBP2L  
Cross-Linking-MS (XL-MS) Homo sapiens
91 HSPB1 3315
Affinity Capture-MS Homo sapiens
92 SP4  
Two-hybrid Homo sapiens
93 PRR20E  
Two-hybrid Homo sapiens
94 KRTAP12-2  
Two-hybrid Homo sapiens
95 HSF1  
Affinity Capture-MS Homo sapiens
96 HNRNPF 3185
Two-hybrid Homo sapiens
97 SPG20 23111
Co-fractionation Homo sapiens
98 DDI2 84301
Co-fractionation Homo sapiens
99 KRAS 3845
Negative Genetic Homo sapiens
100 VIM 7431
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
101 NEMF 9147
Affinity Capture-MS Homo sapiens
102 HIST1H2AE 3012
Affinity Capture-MS Homo sapiens
103 CDH11 1009
Affinity Capture-MS Homo sapiens
104 APOA1 335
Affinity Capture-MS Homo sapiens
105 N4BP1  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which HYPK is involved
No pathways found





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