Gene description for CDH11
Gene name cadherin 11, type 2, OB-cadherin (osteoblast)
Gene symbol CDH11
Other names/aliases CAD11
CDHOB
OB
OSF-4
Species Homo sapiens
 Database cross references - CDH11
ExoCarta ExoCarta_1009
Entrez Gene 1009
HGNC 1750
MIM 600023
UniProt P55287  
 CDH11 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
Hepatocytes 26054723    
 Gene ontology annotations for CDH11
Molecular Function
    calcium ion binding GO:0005509 IEA
Biological Process
    cell adhesion GO:0007155 TAS
    adherens junction organization GO:0034332 TAS
    cell junction assembly GO:0034329 TAS
    ossification GO:0001503 NAS
    homophilic cell adhesion via plasma membrane adhesion molecules GO:0007156 IEA
    skeletal system development GO:0001501 TAS
    cell-cell junction organization GO:0045216 TAS
    corticospinal tract morphogenesis GO:0021957 IEA
Subcellular Localization
    integral component of membrane GO:0016021 IEA
    plasma membrane GO:0005886 TAS
    extracellular exosome GO:0070062 IDA
    cytoplasm GO:0005737 IEA
 Experiment description of studies that identified CDH11 in exosomes
1
Experiment ID 235
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
✘ EV Membrane markers
✔
HSP90B1
EV Negative markers
✔
qNano
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
2
Experiment ID 237
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
✘ EV Membrane markers
✔
HSP90B1
EV Negative markers
✔
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for CDH11
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CDH2 1000
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 CTNNB1 1499
Affinity Capture-Western Homo sapiens
View the network image/svg+xml
 Pathways in which CDH11 is involved
PathwayEvidenceSource
Adherens junctions interactions TAS Reactome





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