Gene description for GSTM4
Gene name glutathione S-transferase mu 4
Gene symbol GSTM4
Other names/aliases GSTM4-4
GTM4
Species Homo sapiens
 Database cross references - GSTM4
ExoCarta ExoCarta_2948
Vesiclepedia VP_2948
Entrez Gene 2948
HGNC 4636
MIM 138333
UniProt Q03013  
 GSTM4 identified in sEVs derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for GSTM4
Molecular Function
    glutathione transferase activity GO:0004364 IBA
    glutathione transferase activity GO:0004364 IDA
    leukotriene-C4 synthase activity GO:0004464 IDA
    protein binding GO:0005515 IPI
    enzyme binding GO:0019899 IPI
    protein homodimerization activity GO:0042803 IPI
    glutathione binding GO:0043295 IDA
Biological Process
    glutathione metabolic process GO:0006749 IBA
    glutathione metabolic process GO:0006749 IDA
    nitrobenzene metabolic process GO:0018916 IEA
    xenobiotic catabolic process GO:0042178 IDA
    long-chain fatty acid biosynthetic process GO:0042759 IDA
Subcellular Localization
    cytoplasm GO:0005737 IDA
    cytosol GO:0005829 IDA
    cytosol GO:0005829 TAS
    intercellular bridge GO:0045171 IDA
 Experiment description of studies that identified GSTM4 in sEVs
1
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for GSTM4
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 NELFCD 51497
Two-hybrid Homo sapiens
2 BAG3 9531
Affinity Capture-MS Homo sapiens
Affinity Capture-Luminescence Homo sapiens
3 LRIF1  
Two-hybrid Homo sapiens
4 UNC119 9094
Two-hybrid Homo sapiens
5 GSTM3 2947
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
6 APLP1 333
Two-hybrid Homo sapiens
7 GSTM4 2948
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
8 MED31  
Two-hybrid Homo sapiens
9 TP53 7157
Two-hybrid Homo sapiens
10 ZBTB16  
Two-hybrid Homo sapiens
11 GSTM2 2946
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 GSTM5 2949
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
13 TLE1 7088
Two-hybrid Homo sapiens
14 IGSF21  
Two-hybrid Homo sapiens
View the network image/svg+xml



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