Gene description for GSTM4
Gene name glutathione S-transferase mu 4
Gene symbol GSTM4
Other names/aliases GSTM4-4
GTM4
Species Homo sapiens
 Database cross references - GSTM4
ExoCarta ExoCarta_2948
Vesiclepedia VP_2948
Entrez Gene 2948
HGNC 4636
MIM 138333
UniProt Q03013  
 GSTM4 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for GSTM4
Molecular Function
    protein binding GO:0005515 IPI
    glutathione binding GO:0043295 IDA
    enzyme binding GO:0019899 IPI
    glutathione transferase activity GO:0004364 IDA
    protein homodimerization activity GO:0042803 IPI
Biological Process
    small molecule metabolic process GO:0044281 TAS
    xenobiotic catabolic process GO:0042178 IDA
    xenobiotic metabolic process GO:0006805 TAS
    glutathione derivative biosynthetic process GO:1901687 TAS
    glutathione metabolic process GO:0006749 IDA
    nitrobenzene metabolic process GO:0018916 IEA
Subcellular Localization
    cytosol GO:0005829 TAS
    cytoplasm GO:0005737 IDA
 Experiment description of studies that identified GSTM4 in exosomes
1
Experiment ID 488
MISEV standards
✔
EM
EV Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
EV Enriched markers
✔
CANX
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for GSTM4
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 GSTM4 2948
Invivo Homo sapiens
Affinity Capture-MS Homo sapiens
Invivo Homo sapiens
Affinity Capture-MS Homo sapiens
2 UNC119 9094
Two-hybrid Homo sapiens
3 APLP1 333
Two-hybrid Homo sapiens
4 TLE1 7088
Two-hybrid Homo sapiens
5 MED31  
Two-hybrid Homo sapiens
6 TP53 7157
Two-hybrid Homo sapiens
7 ZBTB16  
Two-hybrid Homo sapiens
8 NELFCD 51497
Two-hybrid Homo sapiens
9 MGC15730  
Two-hybrid Homo sapiens
10 RIF1  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which GSTM4 is involved
PathwayEvidenceSource
Glutathione conjugation TAS Reactome





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