Gene description for PCCB
Gene name propionyl CoA carboxylase, beta polypeptide
Gene symbol PCCB
Other names/aliases -
Species Homo sapiens
 Database cross references - PCCB
ExoCarta ExoCarta_5096
Vesiclepedia VP_5096
Entrez Gene 5096
HGNC 8654
MIM 232050
UniProt P05166  
 PCCB identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for PCCB
Molecular Function
    propionyl-CoA carboxylase activity GO:0004658 IBA
    propionyl-CoA carboxylase activity GO:0004658 IDA
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
Biological Process
    fatty acid metabolic process GO:0006631 NAS
    branched-chain amino acid metabolic process GO:0009081 NAS
    short-chain fatty acid catabolic process GO:0019626 IC
Subcellular Localization
    mitochondrion GO:0005739 HTP
    mitochondrion GO:0005739 IBA
    mitochondrial matrix GO:0005759 IDA
    mitochondrial matrix GO:0005759 NAS
    mitochondrial matrix GO:0005759 TAS
    cytosol GO:0005829 TAS
    catalytic complex GO:1902494 IPI
 Experiment description of studies that identified PCCB in exosomes
1
Experiment ID 489
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 489
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 490
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 490
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 491
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
6
Experiment ID 491
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
7
Experiment ID 492
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
8
Experiment ID 492
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for PCCB
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ISX  
Proximity Label-MS Homo sapiens
2 HOOK1  
Proximity Label-MS Homo sapiens
3 SPRTN  
Affinity Capture-MS Homo sapiens
4 NDUFS1 4719
Co-fractionation Homo sapiens
5 EBNA-LP  
Affinity Capture-MS
6 MTG2  
Affinity Capture-MS Homo sapiens
7 EPS15 2060
Affinity Capture-MS Homo sapiens
8 MRPL27 51264
Affinity Capture-MS Homo sapiens
9 MCCC1 56922
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 SIRT5 23408
Affinity Capture-MS Homo sapiens
11 NDUFS2 4720
Co-fractionation Homo sapiens
12 TOMM22 56993
Co-fractionation Homo sapiens
13 PLD5  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
14 NDUFS3 4722
Co-fractionation Homo sapiens
15 OGDH 4967
Co-fractionation Homo sapiens
16 PC 5091
Affinity Capture-MS Homo sapiens
17 DCTN4 51164
Proximity Label-MS Homo sapiens
18 YARS2  
Affinity Capture-MS Homo sapiens
19 MRPS24 64951
Affinity Capture-MS Homo sapiens
20 COA3 28958
Co-fractionation Homo sapiens
21 GCAT  
Affinity Capture-MS Homo sapiens
22 FTSJ2 29960
Affinity Capture-MS Homo sapiens
23 HADHA 3030
Co-fractionation Homo sapiens
24 MALSU1  
Affinity Capture-MS Homo sapiens
25 PLD2 5338
Affinity Capture-MS Homo sapiens
26 MINOS1  
Co-fractionation Homo sapiens
27 C20orf24  
Co-fractionation Homo sapiens
28 NDUFV1 4723
Co-fractionation Homo sapiens
29 PHB 5245
Co-fractionation Homo sapiens
30 TOMM40 10452
Co-fractionation Homo sapiens
31 ACSF2 80221
Affinity Capture-MS Homo sapiens
32 AMZ2  
Affinity Capture-MS Homo sapiens
33 DYNLT1 6993
Proximity Label-MS Homo sapiens
34 GATA4  
Affinity Capture-MS Homo sapiens
35 MTCH2 23788
Co-fractionation Homo sapiens
36 PRDM1  
Proximity Label-MS Homo sapiens
37 ACSM5 54988
Affinity Capture-MS Homo sapiens
38 PARK2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
39 AMACR 23600
Affinity Capture-MS Homo sapiens
40 ITSN2 50618
Co-fractionation Homo sapiens
41 ACACA 31
Affinity Capture-MS Homo sapiens
42 PCCA 5095
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
43 ARNT 405
Affinity Capture-MS Homo sapiens
44 UQCRC1 7384
Co-fractionation Homo sapiens
45 HMGCL 3155
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
46 H19 283120
Protein-RNA Homo sapiens
47 PML 5371
Affinity Capture-MS Homo sapiens
48 LYPLA1 10434
Co-fractionation Homo sapiens
49 VDAC2 7417
Co-fractionation Homo sapiens
50 ATP5B 506
Co-fractionation Homo sapiens
51 VSX1  
Proximity Label-MS Homo sapiens
52 OR52B2  
Affinity Capture-MS Homo sapiens
53 UBE2N 7334
Affinity Capture-MS Homo sapiens
54 PER2  
Proximity Label-MS Homo sapiens
55 LARS2 23395
Affinity Capture-MS Homo sapiens
56 HADHB 3032
Co-fractionation Homo sapiens
57 NIPSNAP3A  
Affinity Capture-MS Homo sapiens
58 LHX6  
Proximity Label-MS Homo sapiens
59 MCCC2 64087
Affinity Capture-MS Homo sapiens
60 UQCRC2 7385
Co-fractionation Homo sapiens
61 HOOK3 84376
Proximity Label-MS Homo sapiens
62 ACTN3 89
Two-hybrid Homo sapiens
63 PYCR2 29920
Affinity Capture-MS Homo sapiens
64 HDHD3 81932
Affinity Capture-MS Homo sapiens
65 NXF1 10482
Affinity Capture-RNA Homo sapiens
66 ZNF782  
Co-fractionation Homo sapiens
67 PHB2 11331
Co-fractionation Homo sapiens
68 LACRT 90070
Affinity Capture-MS Homo sapiens
69 IFIT1 3434
Affinity Capture-MS Homo sapiens
70 RPA3 6119
Proximity Label-MS Homo sapiens
71 ALKBH4  
Co-fractionation Homo sapiens
72 ATP6V1A 523
Co-fractionation Homo sapiens
73 PPA2 27068
Affinity Capture-MS Homo sapiens
74 BICD1 636
Proximity Label-MS Homo sapiens
75 LCN1 3933
Affinity Capture-MS Homo sapiens
76 PDPK1 5170
Co-fractionation Homo sapiens
77 PUS1 80324
Affinity Capture-MS Homo sapiens
78 CORO1C 23603
Co-fractionation Homo sapiens
79 SCCPDH 51097
Co-fractionation Homo sapiens
80 HUWE1 10075
Affinity Capture-MS Homo sapiens
81 AK4 205
Affinity Capture-MS Homo sapiens
82 FAM81A  
Affinity Capture-MS Homo sapiens
83 PAF1 54623
Affinity Capture-MS Homo sapiens
84 SCGB2A1 4246
Affinity Capture-MS Homo sapiens
85 ICT1 3396
Affinity Capture-MS Homo sapiens
86 AQP12B  
Affinity Capture-MS Homo sapiens
87 ZNF746  
Affinity Capture-MS Homo sapiens
88 COMMD5 28991
Affinity Capture-MS Homo sapiens
89 NDUFS7 374291
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
90 INPPL1 3636
Affinity Capture-MS Homo sapiens
91 MRI1 84245
Co-fractionation Homo sapiens
92 ARF4 378
Proximity Label-MS Homo sapiens
93 WWP2 11060
Affinity Capture-MS Homo sapiens
94 TRIM37  
Proximity Label-MS Homo sapiens
95 NDUFS8 4728
Co-fractionation Homo sapiens
96 MOV10 4343
Affinity Capture-RNA Homo sapiens
97 C16orf72 29035
Affinity Capture-MS Homo sapiens
98 DHRS4 10901
Affinity Capture-MS Homo sapiens
99 ATP5C1 509
Co-fractionation Homo sapiens
100 VDAC3 7419
Co-fractionation Homo sapiens
101 TRIM43  
Affinity Capture-MS Homo sapiens
102 TOMM5  
Co-fractionation Homo sapiens
View the network image/svg+xml



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