Gene description for PCCA
Gene name propionyl CoA carboxylase, alpha polypeptide
Gene symbol PCCA
Other names/aliases -
Species Homo sapiens
 Database cross references - PCCA
ExoCarta ExoCarta_5095
Vesiclepedia VP_5095
Entrez Gene 5095
HGNC 8653
MIM 232000
UniProt P05165  
 PCCA identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for PCCA
Molecular Function
    propionyl-CoA carboxylase activity GO:0004658 IBA
    propionyl-CoA carboxylase activity GO:0004658 IDA
    propionyl-CoA carboxylase activity GO:0004658 IMP
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    biotin binding GO:0009374 TAS
    enzyme binding GO:0019899 IPI
    metal ion binding GO:0046872 IEA
Biological Process
    fatty acid metabolic process GO:0006631 NAS
    branched-chain amino acid metabolic process GO:0009081 NAS
    short-chain fatty acid catabolic process GO:0019626 IC
Subcellular Localization
    mitochondrion GO:0005739 HTP
    mitochondrion GO:0005739 IBA
    mitochondrion GO:0005739 IDA
    mitochondrial matrix GO:0005759 IDA
    mitochondrial matrix GO:0005759 NAS
    mitochondrial matrix GO:0005759 TAS
    cytosol GO:0005829 TAS
    catalytic complex GO:1902494 IPI
 Experiment description of studies that identified PCCA in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
6
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
7
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
8
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for PCCA
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 AIDA 64853
Co-fractionation Homo sapiens
2 HNRNPH1 3187
Affinity Capture-RNA Homo sapiens
3 AK4 205
Affinity Capture-MS Homo sapiens
4 PSME2 5721
Co-fractionation Homo sapiens
5 OR52B2  
Affinity Capture-MS Homo sapiens
6 UBE2N 7334
Affinity Capture-MS Homo sapiens
7 ISX  
Proximity Label-MS Homo sapiens
8 FAM81A  
Affinity Capture-MS Homo sapiens
9 HOOK1  
Proximity Label-MS Homo sapiens
10 RARS2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 FTSJ2 29960
Affinity Capture-MS Homo sapiens
12 PNPLA4  
Affinity Capture-MS Homo sapiens
13 SGK1  
Affinity Capture-MS Homo sapiens
14 NIPSNAP3A  
Affinity Capture-MS Homo sapiens
15 NAA38  
Affinity Capture-MS Homo sapiens
16 DYNLT1 6993
Proximity Label-MS Homo sapiens
17 MCCC2 64087
Affinity Capture-MS Homo sapiens
18 C20orf96  
Affinity Capture-MS Homo sapiens
19 LAMP3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 HIST1H4A 8359
Affinity Capture-MS Homo sapiens
21 PCCB 5096
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
22 H19 283120
Protein-RNA Homo sapiens
23 AQP12B  
Affinity Capture-MS Homo sapiens
24 ZNF746  
Affinity Capture-MS Homo sapiens
25 RPA2 6118
Proximity Label-MS Homo sapiens
26 LGALS3 3958
Affinity Capture-MS Homo sapiens
27 EBNA-LP  
Affinity Capture-MS
28 TAZ  
Affinity Capture-MS Homo sapiens
29 MTG2  
Affinity Capture-MS Homo sapiens
30 ICMT  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
31 ACSM5 54988
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
32 MCC 4163
Two-hybrid Homo sapiens
33 MRPL27 51264
Affinity Capture-MS Homo sapiens
34 MCCC1 56922
Affinity Capture-MS Homo sapiens
35 FAHD1 81889
Affinity Capture-MS Homo sapiens
36 HOOK3 84376
Proximity Label-MS Homo sapiens
37 PARK2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
38 FPR1  
Affinity Capture-MS Homo sapiens
39 PLD5  
Affinity Capture-MS Homo sapiens
40 DDX58 23586
Affinity Capture-RNA Homo sapiens
41 HDHD3 81932
Affinity Capture-MS Homo sapiens
42 GGA1 26088
Co-fractionation Homo sapiens
43 COL6A1 1291
Co-fractionation Homo sapiens
44 SQSTM1 8878
Proximity Label-MS Homo sapiens
45 RIPK3 11035
Affinity Capture-MS Homo sapiens
46 PER2  
Proximity Label-MS Homo sapiens
47 ACACA 31
Affinity Capture-MS Homo sapiens
48 PAF1 54623
Affinity Capture-MS Homo sapiens
49 VSX1  
Proximity Label-MS Homo sapiens
50 TMEM132D  
Two-hybrid Homo sapiens
51 IFIT1 3434
Affinity Capture-MS Homo sapiens
52 RPA3 6119
Proximity Label-MS Homo sapiens
53 PC 5091
Affinity Capture-MS Homo sapiens
54 WDYHV1  
Affinity Capture-MS Homo sapiens
55 SLX4  
Affinity Capture-MS Homo sapiens
56 DCTN4 51164
Proximity Label-MS Homo sapiens
57 PIGR 5284
Affinity Capture-MS Homo sapiens
58 DIAPH2  
Co-fractionation Homo sapiens
59 IP6K3  
Affinity Capture-MS Homo sapiens
60 THBS3 7059
Affinity Capture-MS Homo sapiens
61 TTC1 7265
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
62 YARS2  
Affinity Capture-MS Homo sapiens
63 BICD1 636
Proximity Label-MS Homo sapiens
64 THG1L 54974
Co-fractionation Homo sapiens
65 MRPS24 64951
Affinity Capture-MS Homo sapiens
66 Ppp2r3a  
Affinity Capture-MS Mus musculus
67 GCAT  
Affinity Capture-MS Homo sapiens
68 GATA4  
Affinity Capture-MS Homo sapiens
69 TRIM43  
Affinity Capture-MS Homo sapiens
70 Cxxc1  
Affinity Capture-MS Mus musculus
71 TBC1D25  
Affinity Capture-MS Homo sapiens
72 YBEY  
Affinity Capture-MS Homo sapiens
73 PML 5371
Affinity Capture-MS Homo sapiens
74 UQCRFS1 7386
Affinity Capture-MS Homo sapiens
75 MALSU1  
Affinity Capture-MS Homo sapiens
76 ARF4 378
Proximity Label-MS Homo sapiens
77 PLD2 5338
Affinity Capture-MS Homo sapiens
78 HUWE1 10075
Affinity Capture-MS Homo sapiens
79 Nup155  
Affinity Capture-MS Mus musculus
80 NDUFS7 374291
Affinity Capture-MS Homo sapiens
81 SP100 6672
Affinity Capture-MS Homo sapiens
82 ERRFI1 54206
Two-hybrid Homo sapiens
View the network image/svg+xml



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