Gene description for DCAF4L2
Gene name DDB1 and CUL4 associated factor 4-like 2
Gene symbol DCAF4L2
Other names/aliases WDR21C
Species Homo sapiens
 Database cross references - DCAF4L2
ExoCarta ExoCarta_138009
Vesiclepedia VP_138009
Entrez Gene 138009
HGNC 26657
UniProt Q8NA75  
 DCAF4L2 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for DCAF4L2
Subcellular Localization
    Cul4-RING E3 ubiquitin ligase complex GO:0080008 IBA
 Experiment description of studies that identified DCAF4L2 in exosomes
1
Experiment ID 235
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for DCAF4L2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CCT6A 908
Affinity Capture-MS Homo sapiens
2 DDB1 1642
Affinity Capture-MS Homo sapiens
3 TCP1 6950
Affinity Capture-MS Homo sapiens
4 LONP1 9361
Affinity Capture-MS Homo sapiens
5 ANKRD40 91369
Affinity Capture-MS Homo sapiens
6 COPS2 9318
Affinity Capture-MS Homo sapiens
7 CLUH 23277
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 CCT6B 10693
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 CUL4B 8450
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 PDRG1  
Affinity Capture-MS Homo sapiens
11 CUL4A 8451
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 PYGL 5836
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 CCT2 10576
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which DCAF4L2 is involved
No pathways found





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