Gene description for ACOT2
Gene name acyl-CoA thioesterase 2
Gene symbol ACOT2
Other names/aliases CTE-IA
CTE1A
MTE1
PTE2
PTE2A
ZAP128
Species Homo sapiens
 Database cross references - ACOT2
ExoCarta ExoCarta_10965
Vesiclepedia VP_10965
Entrez Gene 10965
HGNC 18431
MIM 609972
UniProt P49753  
 ACOT2 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for ACOT2
Molecular Function
    protein binding GO:0005515 IPI
    fatty acyl-CoA hydrolase activity GO:0047617 IBA
    fatty acyl-CoA hydrolase activity GO:0047617 IDA
    carboxylic ester hydrolase activity GO:0052689 IEA
Biological Process
    very long-chain fatty acid metabolic process GO:0000038 IDA
    long-chain fatty acid metabolic process GO:0001676 IDA
    fatty acid metabolic process GO:0006631 IBA
    acyl-CoA metabolic process GO:0006637 IBA
    acyl-CoA metabolic process GO:0006637 IDA
Subcellular Localization
    mitochondrion GO:0005739 HTP
    mitochondrion GO:0005739 IDA
    mitochondrial matrix GO:0005759 TAS
    peroxisomal matrix GO:0005782 TAS
    cytosol GO:0005829 TAS
 Experiment description of studies that identified ACOT2 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for ACOT2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SLIRP 81892
Proximity Label-MS Homo sapiens
2 MTCH1 23787
Proximity Label-MS Homo sapiens
3 TRUB2  
Proximity Label-MS Homo sapiens
4 MTG2  
Proximity Label-MS Homo sapiens
5 NGRN  
Proximity Label-MS Homo sapiens
6 CHCHD1  
Proximity Label-MS Homo sapiens
7 MRPL37 51253
Affinity Capture-MS Homo sapiens
8 CNP 1267
Affinity Capture-MS Homo sapiens
9 RPUSD4 84881
Proximity Label-MS Homo sapiens
10 MTRF1  
Proximity Label-MS Homo sapiens
11 GFM2 84340
Proximity Label-MS Homo sapiens
12 CCDC90B  
Proximity Label-MS Homo sapiens
13 ZNF3  
Affinity Capture-MS Homo sapiens
14 LRPPRC 10128
Proximity Label-MS Homo sapiens
15 MCU 90550
Proximity Label-MS Homo sapiens
16 CRYZ 1429
Proximity Label-MS Homo sapiens
17 TFAM 7019
Proximity Label-MS Homo sapiens
18 PMPCA 23203
Proximity Label-MS Homo sapiens
19 C8orf82  
Proximity Label-MS Homo sapiens
20 HINT2 84681
Proximity Label-MS Homo sapiens
21 SLC25A12 8604
Proximity Label-MS Homo sapiens
22 SURF1  
Proximity Label-MS Homo sapiens
23 EXD2  
Proximity Label-MS Homo sapiens
24 WDR18 57418
Affinity Capture-MS Homo sapiens
25 PMPCB 9512
Proximity Label-MS Homo sapiens
26 TACO1  
Proximity Label-MS Homo sapiens
27 FASTKD2  
Proximity Label-MS Homo sapiens
28 VWA8 23078
Proximity Label-MS Homo sapiens
29 MTERF3  
Proximity Label-MS Homo sapiens
30 MDH2 4191
Proximity Label-MS Homo sapiens
31 ZNF277  
Affinity Capture-MS Homo sapiens
32 C6orf203  
Proximity Label-MS Homo sapiens
33 COX15 1355
Proximity Label-MS Homo sapiens
34 FASTKD5  
Proximity Label-MS Homo sapiens
35 MRPS26 64949
Proximity Label-MS Homo sapiens
36 LDHD  
Affinity Capture-MS Homo sapiens
37 TUFM 7284
Proximity Label-MS Homo sapiens
38 CCDC109B 55013
Proximity Label-MS Homo sapiens
39 GFM1 85476
Proximity Label-MS Homo sapiens
40 MTFMT  
Proximity Label-MS Homo sapiens
41 MRPL11 65003
Proximity Label-MS Homo sapiens
42 MTRF1L  
Proximity Label-MS Homo sapiens
43 TMEM70  
Proximity Label-MS Homo sapiens
44 OTC 5009
Proximity Label-MS Homo sapiens
45 WBSCR16  
Proximity Label-MS Homo sapiens
46 MRRF  
Proximity Label-MS Homo sapiens
47 AIFM1 9131
Proximity Label-MS Homo sapiens
48 MRPS12  
Proximity Label-MS Homo sapiens
49 MTIF2 4528
Proximity Label-MS Homo sapiens
50 MTIF3  
Proximity Label-MS Homo sapiens
51 RMND1 55005
Proximity Label-MS Homo sapiens
52 ARF6 382
Proximity Label-MS Homo sapiens
53 DHX30 22907
Proximity Label-MS Homo sapiens
54 C12orf65  
Proximity Label-MS Homo sapiens
55 MTG1  
Proximity Label-MS Homo sapiens
56 ACAD9 28976
Proximity Label-MS Homo sapiens
57 CLPB 81570
Proximity Label-MS Homo sapiens
58 METTL15  
Proximity Label-MS Homo sapiens
59 MCUR1 63933
Proximity Label-MS Homo sapiens
60 CS 1431
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
61 C17orf80 55028
Proximity Label-MS Homo sapiens
62 PHB2 11331
Proximity Label-MS Homo sapiens
63 TSFM 10102
Proximity Label-MS Homo sapiens
64 AUH 549
Proximity Label-MS Homo sapiens
65 ICT1 3396
Proximity Label-MS Homo sapiens
66 LONP1 9361
Proximity Label-MS Homo sapiens
67 NLGN3  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
68 PDHA1 5160
Proximity Label-MS Homo sapiens
69 COX8A  
Proximity Label-MS Homo sapiens
70 C21orf33  
Proximity Label-MS Homo sapiens
71 SSBP1 6742
Proximity Label-MS Homo sapiens
72 SFXN1 94081
Proximity Label-MS Homo sapiens
73 FASTKD3  
Proximity Label-MS Homo sapiens
74 RBM23  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
75 TBRG4 9238
Proximity Label-MS Homo sapiens
76 AARS2  
Proximity Label-MS Homo sapiens
77 SPATA33  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
78 TEFM  
Proximity Label-MS Homo sapiens
79 ACOT1 641371
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
80 C19orf52  
Proximity Label-MS Homo sapiens
81 SLC25A51  
Proximity Label-MS Homo sapiens
82 RPUSD3  
Proximity Label-MS Homo sapiens
83 GRSF1 2926
Proximity Label-MS Homo sapiens
84 C1QBP 708
Proximity Label-MS Homo sapiens
85 PEX5 5830
Protein-peptide Homo sapiens
86 METTL17  
Proximity Label-MS Homo sapiens
View the network image/svg+xml



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