Gene description for ADH6
Gene name alcohol dehydrogenase 6 (class V)
Gene symbol ADH6
Other names/aliases ADH-5
Species Homo sapiens
 Database cross references - ADH6
ExoCarta ExoCarta_130
Vesiclepedia VP_130
Entrez Gene 130
HGNC 255
MIM 103735
UniProt P28332  
 ADH6 identified in exosomes derived from the following tissue/cell type
Urine 19056867    
 Gene ontology annotations for ADH6
Molecular Function
    alcohol dehydrogenase (NAD+) activity GO:0004022 IBA
    alcohol dehydrogenase (NAD+) activity GO:0004022 IDA
    all-trans-retinol dehydrogenase (NAD+) activity GO:0004745 IBA
    zinc ion binding GO:0008270 IBA
    zinc ion binding GO:0008270 NAS
Biological Process
    retinol metabolic process GO:0042572 IBA
    retinoic acid metabolic process GO:0042573 IBA
Subcellular Localization
    cytosol GO:0005829 IBA
    cytosol GO:0005829 TAS
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified ADH6 in exosomes
1
Experiment ID 63
MISEV standards
Biophysical techniques
AQP2
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors "Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA"
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for ADH6
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 RSL1D1 26156
Two-hybrid Homo sapiens
2 RPAIN  
Two-hybrid Homo sapiens
3 ANKRD17 26057
Two-hybrid Homo sapiens
4 RPS29 6235
Two-hybrid Homo sapiens
5 TNIP1 10318
Two-hybrid Homo sapiens
6 ARRB1 408
Two-hybrid Homo sapiens
7 KRAS 3845
Two-hybrid Homo sapiens
8 RASSF5 83593
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which ADH6 is involved
PathwayEvidenceSource
Biological oxidations TAS Reactome
Ethanol oxidation TAS Reactome
Metabolism TAS Reactome
Phase I - Functionalization of compounds TAS Reactome





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