Gene description for ADH6
Gene name alcohol dehydrogenase 6 (class V)
Gene symbol ADH6
Other names/aliases ADH-5
Species Homo sapiens
 Database cross references - ADH6
ExoCarta ExoCarta_130
Entrez Gene 130
HGNC 255
MIM 103735
UniProt P28332  
 ADH6 identified in exosomes derived from the following tissue/cell type
Urine 19056867    
 Gene ontology annotations for ADH6
Molecular Function
    alcohol dehydrogenase activity, zinc-dependent GO:0004024 IEA
    zinc ion binding GO:0008270 NAS
    alcohol dehydrogenase (NAD) activity GO:0004022 IDA
    ethanol binding GO:0035276 IEA
Biological Process
    response to ethanol GO:0045471 IDA
    ethanol oxidation GO:0006069 TAS
    small molecule metabolic process GO:0044281 TAS
    xenobiotic metabolic process GO:0006805 TAS
Subcellular Localization
    cytosol GO:0005829 TAS
    extracellular exosome GO:0070062 IDA
 Experiment description of studies that identified ADH6 in exosomes
1
Experiment ID 63
ISEV standards
✘ EV Biophysical techniques
✘ EV Cytosolic markers
✔
AQP2
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for ADH6
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which ADH6 is involved
PathwayEvidenceSource
Ethanol oxidation TAS Reactome





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