Gene description for KRT16
Gene name keratin 16, type I
Gene symbol KRT16
Other names/aliases CK16
FNEPPK
K16
K1CP
KRT16A
NEPPK
PC1
Species Homo sapiens
 Database cross references - KRT16
ExoCarta ExoCarta_3868
Vesiclepedia VP_3868
Entrez Gene 3868
HGNC 6423
MIM 148067
UniProt P08779  
 KRT16 identified in exosomes derived from the following tissue/cell type
Bladder cancer cells 20224111    
Chondrocytes 35931686    
Chondrocytes 35931686    
Chondrocytes 35931686    
Chondrocytes 35931686    
Colorectal cancer cells 17956143    
Colorectal cancer cells 19837982    
Colorectal cancer cells 23161513    
Colorectal cancer cells 23161513    
Colorectal cancer cells 23161513    
Colorectal cancer cells 34887515    
Keratinocytes 19530224    
Keratinocytes 19530224    
Mesenchymal stem cells Unpublished / Not applicable
Mesenchymal stem cells 36408942    
Neuroblastoma cells 25944692    
Prostate cancer cells 25844599    
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
Saliva 19199708    
Squamous carcinoma cells 20124223    
 Gene ontology annotations for KRT16
Molecular Function
    structural constituent of cytoskeleton GO:0005200 NAS
    protein binding GO:0005515 IPI
Biological Process
    morphogenesis of an epithelium GO:0002009 ISS
    inflammatory response GO:0006954 ISS
    cytoskeleton organization GO:0007010 NAS
    keratinocyte differentiation GO:0030216 ISS
    negative regulation of cell migration GO:0030336 IDA
    epithelial cell differentiation GO:0030855 IBA
    keratinization GO:0031424 ISS
    hair cycle GO:0042633 IDA
    innate immune response GO:0045087 ISS
    intermediate filament organization GO:0045109 IBA
    keratinocyte migration GO:0051546 ISS
    establishment of skin barrier GO:0061436 ISS
Subcellular Localization
    cornified envelope GO:0001533 IEA
    nucleus GO:0005634 HDA
    cytosol GO:0005829 TAS
    cytoskeleton GO:0005856 IBA
    cytoskeleton GO:0005856 IDA
    intermediate filament GO:0005882 NAS
    keratin filament GO:0045095 IBA
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified KRT16 in exosomes
1
Experiment ID 76
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|GAPDH|HSP90|CD81|CD9|CD63|LAMP1|MHCI
Enriched markers
✔
HSP90B1
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20224111    
Organism Homo sapiens
Experiment description Proteomics analysis of bladder cancer exosomes.
Authors "Welton JL, Khanna S, Giles PJ, Brennan P, Brewis IA, Staffurth J, Mason MD, Clayton A."
Journal name MCP
Publication year 2010
Sample Bladder cancer cells
Sample name HT1376
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.10-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [MALDI TOF/TOF]
Western blotting
FACS
2
Experiment ID 494
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD151|CD63|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|SDCBP|TFRC|TSG101
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name Osteoarthritic cartilage
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 496
MISEV standards
✘ Biophysical techniques
✔
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|SDCBP|TFRC|TSG101
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name Healthy cartilage
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 497
MISEV standards
✘ Biophysical techniques
✔
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|RAB5A|SDCBP|TFRC|TSG101|UCHL1
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 498
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|RAB5A|SDCBP|TFRC|TSG101|UCHL1
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
6
Experiment ID 20
MISEV standards
✔
EM
Biophysical techniques
✔
HSP90|CD63|CD81|LAMP1
Enriched markers
✔
GOLGA2|cytochrome c
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 17956143    
Organism Homo sapiens
Experiment description Proteomic analysis of microvesicles derived from human colorectal cancer cells.
Authors "Choi DS, Lee JM, Park GW, Lim HW, Bang JY, Kim YK, Kwon KH, Kwon HJ, Kim KP, Gho YS"
Journal name JPR
Publication year 2007
Sample Colorectal cancer cells
Sample name HT29
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Diafiltration
Flotation density 1.16 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
7
Experiment ID 21
MISEV standards
✔
EM|IEM
Biophysical techniques
✔
Alix|TSG101|HSP70|CD63
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method
Mass spectrometry   
PubMed ID 19837982    
Organism Homo sapiens
Experiment description Proteomic and bioinformatic analysis of immunoaffinity-purified exosomes derived from the human colon tumor cell line LIM1215.
Authors "Suresh Mathivanan, Justin W.E. Lim, Bow J. Tauro, Hong Ji, Robert L. Moritz and Richard J. Simpson"
Journal name MCP
Publication year 2009
Sample Colorectal cancer cells
Sample name LIM1215
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.10-1.12 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [Orbitrap]
Western blotting
8
Experiment ID 207
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|HSP70|FLOT1
Enriched markers
✔
VDAC
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name DKO-1
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
9
Experiment ID 208
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|HSP70|FLOT1
Enriched markers
✔
VDAC
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name Dks-8
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
10
Experiment ID 209
MISEV standards
✘ Biophysical techniques
✔
TSG101|HSP70|FLOT1
Enriched markers
✔
VDAC
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name DLD-1
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
11
Experiment ID 1203
MISEV standards
✔
EM
Biophysical techniques
✔
SDCBP|FLOT1|CD9|CD81|CD63|EPCAM|GAPDH|LAMP1|TFRC|CD151|CD82|LAMP2|RAB35|TSG101|FLOT2|RAB5B|ICAM1|RAB5A
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 34887515    
Organism Homo sapiens
Experiment description Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets
Authors "Zhang Q, Jeppesen DK, Higginbotham JN, Graves-Deal R, Trinh VQ, Ramirez MA, Sohn Y, Neininger AC, Taneja N, McKinley ET, Niitsu H, Cao Z, Evans R, Glass SE, Ray KC, Fissell WH, Hill S, Rose KL, Huh WJ, Washington MK, Ayers GD, Burnette DT, Sharma S, Rome LH, Franklin JL, Lee YA, Liu Q, Coffey RJ."
Journal name Nat Cell Biol
Publication year 2021
Sample Colorectal cancer cells
Sample name DiFi
Isolation/purification methods Differential centrifugation
Filtration
Centrifugal ultrafiltration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
miRNA
Methods used in the study Western blotting
Mass spectrometry
RNA sequencing
12
Experiment ID 189
MISEV standards
✔
EM
Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19530224    
Organism Homo sapiens
Experiment description Profile of exosomes related proteins released by differentiated and undifferentiated human keratinocytes.
Authors "Chavez-Muñoz C, Kilani RT, Ghahary A."
Journal name J Cell Physiol
Publication year 2009
Sample Keratinocytes
Sample name Keratinocytes - Differentiated
Isolation/purification methods Differential centrifugation
Filtration
Sucrose cushion
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
13
Experiment ID 190
MISEV standards
✔
EM
Biophysical techniques
✔
HSC70
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19530224    
Organism Homo sapiens
Experiment description Profile of exosomes related proteins released by differentiated and undifferentiated human keratinocytes.
Authors "Chavez-Muñoz C, Kilani RT, Ghahary A."
Journal name J Cell Physiol
Publication year 2009
Sample Keratinocytes
Sample name Keratinocytes - Undifferentiated
Isolation/purification methods Differential centrifugation
Filtration
Sucrose cushion
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
14
Experiment ID 126
MISEV standards
✘ Biophysical techniques
✔
GAPDH
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry [LTQ-FT Ultra]
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors "Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim"
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
15
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
16
Experiment ID 224
MISEV standards
✔
EM|AFM
Biophysical techniques
✔
Alix|TSG101|CD63|CD81
Enriched markers
✔
GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors "Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S"
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
17
Experiment ID 274
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|RAB5A|CD9|CD82|CD63|CD81
Enriched markers
✔
AIF
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors "Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T."
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel resistant
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.18 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Flow cytometry
Western blotting
18
Experiment ID 834
MISEV standards
✔
EM
Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
19
Experiment ID 835
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
20
Experiment ID 66
MISEV standards
✔
IEM
Biophysical techniques
✔
TSG101|Alix|CD63|CD81
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19199708    
Organism Homo sapiens
Experiment description Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).
Authors "Gonzalez-Begne M, Lu B, Han X, Hagen FK, Hand AR, Melvin JE, Yates JR"
Journal name JPR
Publication year 2009
Sample Saliva
Sample name Saliva
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
Immunoelectron Microscopy
21
Experiment ID 191
MISEV standards
✘ Biophysical techniques
✔
Alix|CD81|CD9
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20124223    
Organism Homo sapiens
Experiment description Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of proteins and exosomes.
Authors "Park JE, Tan HS, Datta A, Lai RC, Zhang H, Meng W, Lim SK, Sze SK."
Journal name Mol Cell Proteomics
Publication year 2010
Sample Squamous carcinoma cells
Sample name Squamous carcinoma cell (A431)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for KRT16
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 UBE2H 7328
Affinity Capture-MS Homo sapiens
2 KRT76 51350
Two-hybrid Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
3 KRT4 3851
Two-hybrid Homo sapiens
4 KRT73 319101
Two-hybrid Homo sapiens
5 GNG10 2790
Two-hybrid Homo sapiens
6 EPM2AIP1 9852
Two-hybrid Homo sapiens
7 KRT6B 3854
Cross-Linking-MS (XL-MS) Homo sapiens
8 KRT1 3848
Two-hybrid Homo sapiens
9 SHC1 6464
Affinity Capture-MS Homo sapiens
10 KIFC3 3801
Two-hybrid Homo sapiens
11 KRT6A 3853
Cross-Linking-MS (XL-MS) Homo sapiens
Two-hybrid Homo sapiens
12 TRIM26 7726
Affinity Capture-MS Homo sapiens
13 CARD9 64170
Two-hybrid Homo sapiens
14 CRK 1398
Affinity Capture-MS Homo sapiens
15 ALB 213
Affinity Capture-MS Homo sapiens
16 EPS15 2060
Affinity Capture-MS Homo sapiens
17 CALCOCO1 57658
Affinity Capture-MS Homo sapiens
18 GAS8  
Two-hybrid Homo sapiens
19 KRT82 3888
Co-fractionation Homo sapiens
20 CAND1 55832
Affinity Capture-MS Homo sapiens
21 KIF7 374654
Affinity Capture-MS Homo sapiens
22 NEFM 4741
Affinity Capture-MS Homo sapiens
23 RPS6KB2  
Affinity Capture-MS Homo sapiens
24 AMOTL1 154810
Affinity Capture-MS Homo sapiens
25 KIAA1429 25962
Affinity Capture-MS Homo sapiens
26 WTAP 9589
Affinity Capture-MS Homo sapiens
27 HP 3240
Cross-Linking-MS (XL-MS) Homo sapiens
28 INA 9118
Affinity Capture-MS Homo sapiens
29 KRT71 112802
Two-hybrid Homo sapiens
30 Invs  
Affinity Capture-MS Mus musculus
31 COPS5 10987
Affinity Capture-MS Homo sapiens
32 POLL  
Two-hybrid Homo sapiens
33 HGS 9146
Two-hybrid Homo sapiens
34 OBSL1 23363
Affinity Capture-MS Homo sapiens
35 SEMA4C 54910
Two-hybrid Homo sapiens
36 KRT5 3852
Co-fractionation Homo sapiens
Two-hybrid Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
37 KRT78 196374
Two-hybrid Homo sapiens
38 ITGA4 3676
Affinity Capture-MS Homo sapiens
39 PUS10  
Two-hybrid Homo sapiens
40 KRT72 140807
Two-hybrid Homo sapiens
41 KRT83  
Two-hybrid Homo sapiens
42 MECP2 4204
Affinity Capture-MS Homo sapiens
43 CUL1 8454
Affinity Capture-MS Homo sapiens
44 TFCP2 7024
Affinity Capture-MS Homo sapiens
45 AMOT  
Two-hybrid Homo sapiens
46 C1orf216  
Two-hybrid Homo sapiens
47 KRT8 3856
Two-hybrid Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
48 PTPRN2  
Proximity Label-MS Homo sapiens
49 TRIM7  
Affinity Capture-MS Homo sapiens
50 PRPH 5630
Two-hybrid Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
51 CUL4B 8450
Affinity Capture-MS Homo sapiens
52 KLC4 89953
Two-hybrid Homo sapiens
53 CBL 867
Affinity Capture-MS Homo sapiens
54 UBASH3B 84959
Affinity Capture-MS Homo sapiens
55 TXLNG  
Affinity Capture-MS Homo sapiens
56 KRT80 144501
Two-hybrid Homo sapiens
57 VCP 7415
Affinity Capture-MS Homo sapiens
58 EFNA3  
Affinity Capture-MS Homo sapiens
59 TCHP  
Two-hybrid Homo sapiens
60 KRT75 9119
Cross-Linking-MS (XL-MS) Homo sapiens
61 RLIM 51132
Affinity Capture-MS Homo sapiens
62 PKN1 5585
Two-hybrid Homo sapiens
63 CCDC101  
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
64 PPP1R18 170954
Two-hybrid Homo sapiens
65 KRT2 3849
Two-hybrid Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
66 CUL2 8453
Affinity Capture-MS Homo sapiens
67 DDX39B 7919
Affinity Capture-MS Homo sapiens
68 YAP1 10413
Affinity Capture-MS Homo sapiens
69 KRT79 338785
Two-hybrid Homo sapiens
70 CYLD  
Affinity Capture-MS Homo sapiens
71 Cep290  
Affinity Capture-MS Mus musculus
72 KRT85  
Two-hybrid Homo sapiens
73 GAN 8139
Affinity Capture-MS Homo sapiens
74 KRT3 3850
Two-hybrid Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
75 EFNA4  
Affinity Capture-MS Homo sapiens
76 METTL14  
Affinity Capture-MS Homo sapiens
77 CCNC  
Two-hybrid Homo sapiens
78 USP15 9958
Affinity Capture-MS Homo sapiens
79 RC3H2  
Affinity Capture-MS Homo sapiens
80 KRT86  
Two-hybrid Homo sapiens
81 IQCB1  
Affinity Capture-MS Homo sapiens
82 PRKAA2 5563
Two-hybrid Homo sapiens
83 TXLNB  
Two-hybrid Homo sapiens
84 DIRAS2 54769
Affinity Capture-MS Homo sapiens
85 CUL3 8452
Affinity Capture-MS Homo sapiens
86 DES 1674
Cross-Linking-MS (XL-MS) Homo sapiens
87 EGFR 1956
Affinity Capture-MS Homo sapiens
88 HNRNPA1 3178
Affinity Capture-MS Homo sapiens
89 TTC23  
Two-hybrid Homo sapiens
90 FN1 2335
Affinity Capture-MS Homo sapiens
91 ARFGEF2 10564
Affinity Capture-MS Homo sapiens
92 AP2M1 1173
Affinity Capture-MS Homo sapiens
93 KRT81  
Two-hybrid Homo sapiens
94 MAPK6  
Affinity Capture-MS Homo sapiens
95 MYC  
Affinity Capture-MS Homo sapiens
96 BANF1 8815
Affinity Capture-MS Homo sapiens
97 FBXO2 26232
Affinity Capture-Western Homo sapiens
98 USHBP1  
Two-hybrid Homo sapiens
99 PCM1 5108
Affinity Capture-MS Homo sapiens
100 KRT19 3880
Cross-Linking-MS (XL-MS) Homo sapiens
101 CCDC8  
Affinity Capture-MS Homo sapiens
102 DSP 1832
Co-fractionation Homo sapiens
103 TXLNA 200081
Affinity Capture-MS Homo sapiens
104 SYNC  
Affinity Capture-MS Homo sapiens
105 EIF3F 8665
Affinity Capture-MS Homo sapiens
106 PLEC 5339
Affinity Capture-MS Homo sapiens
107 GRB2 2885
Affinity Capture-MS Homo sapiens
108 KRT84 3890
Cross-Linking-MS (XL-MS) Homo sapiens
109 TP53 7157
Affinity Capture-MS Homo sapiens
110 CCHCR1  
Two-hybrid Homo sapiens
111 INPPL1 3636
Affinity Capture-MS Homo sapiens
112 CCDC146  
Two-hybrid Homo sapiens
113 DDX3X 1654
Affinity Capture-MS Homo sapiens
114 KRT10 3858
Co-fractionation Homo sapiens
115 FBXO21  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
116 ARF5 381
Proximity Label-MS Homo sapiens
117 EFNA1  
Affinity Capture-MS Homo sapiens
118 CDK18 5129
Two-hybrid Homo sapiens
119 HNRNPM 4670
Co-fractionation Homo sapiens
120 FSD1  
Affinity Capture-MS Homo sapiens
121 SNAPIN 23557
Two-hybrid Homo sapiens
122 Iqcb1  
Affinity Capture-MS Mus musculus
123 EIF4A3 9775
Affinity Capture-MS Homo sapiens
124 ARFIP2 23647
Two-hybrid Homo sapiens
125 KRT6C 286887
Two-hybrid Homo sapiens
126 RNF38  
Affinity Capture-MS Homo sapiens
127 KRT74 121391
Two-hybrid Homo sapiens
128 C1orf109  
Two-hybrid Homo sapiens
129 ARF1 375
Proximity Label-MS Homo sapiens
130 CCDC17 149483
Two-hybrid Homo sapiens
131 ZUFSP 221302
Affinity Capture-MS Homo sapiens
132 PIK3R2 5296
Affinity Capture-MS Homo sapiens
133 LMO1  
Two-hybrid Homo sapiens
134 RC3H1 149041
Affinity Capture-MS Homo sapiens
135 VIM 7431
Cross-Linking-MS (XL-MS) Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
136 Nphp1  
Affinity Capture-MS Mus musculus
137 KRT7 3855
Cross-Linking-MS (XL-MS) Homo sapiens
138 NEDD8 4738
Affinity Capture-MS Homo sapiens
139 APOA1 335
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which KRT16 is involved
PathwayEvidenceSource
Developmental Biology TAS Reactome
Formation of the cornified envelope TAS Reactome
Keratinization TAS Reactome





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