Gene description for CARD9
Gene name caspase recruitment domain family, member 9
Gene symbol CARD9
Other names/aliases CANDF2
hCARD9
Species Homo sapiens
 Database cross references - CARD9
ExoCarta ExoCarta_64170
Entrez Gene 64170
HGNC 16391
MIM 607212
UniProt Q9H257  
 CARD9 identified in exosomes derived from the following tissue/cell type
Prostate cancer cells 25844599    
 Gene ontology annotations for CARD9
Molecular Function
    protein binding GO:0005515 IPI
    CARD domain binding GO:0050700 IPI
    protein homodimerization activity GO:0042803 IPI
Biological Process
    response to drug GO:0042493 IEA
    response to exogenous dsRNA GO:0043330 IEA
    regulation of interleukin-2 biosynthetic process GO:0045076 IEA
    response to fungus GO:0009620 IEA
    regulation of apoptotic process GO:0042981 IEA
    positive regulation of stress-activated MAPK cascade GO:0032874 IDA
    regulation of interleukin-6 biosynthetic process GO:0045408 IEA
    defense response to virus GO:0051607 IEA
    response to muramyl dipeptide GO:0032495 IEA
    response to peptidoglycan GO:0032494 IEA
    positive regulation of JNK cascade GO:0046330 IDA
    nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway GO:0035872 TAS
    regulation of tumor necrosis factor biosynthetic process GO:0042534 IEA
    positive regulation of interleukin-6 production GO:0032755 IEA
    positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 IEP
    nucleotide-binding oligomerization domain containing signaling pathway GO:0070423 TAS
    stimulatory C-type lectin receptor signaling pathway GO:0002223 TAS
    positive regulation of tumor necrosis factor production GO:0032760 IEA
    defense response to Gram-positive bacterium GO:0050830 IEA
    innate immune response GO:0045087 TAS
Subcellular Localization
    cytoplasm GO:0005737 IDA
    cytosol GO:0005829 TAS
    plasma membrane GO:0005886 TAS
 Experiment description of studies that identified CARD9 in exosomes
1
Experiment ID 275
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|RAB5A
EV Cytosolic markers
CD9|CD82|CD63|CD81
EV Membrane markers
AIF
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T.
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel sensitive
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.12-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry/Flow cytometry/Western blotting
 Protein-protein interactions for CARD9
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 DIPA  
Two-hybrid Homo sapiens
2 KIAA0408  
Two-hybrid Homo sapiens
3 BCL10  
Invivo Homo sapiens
Invitro Homo sapiens
View the network image/svg+xml
 Pathways in which CARD9 is involved
PathwayEvidenceSource
CLEC7A (Dectin-1) signaling TAS Reactome
NOD1/2 Signaling Pathway TAS Reactome





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